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Registry of Toxic Effects of Chemical Substances (RTECS)

Platinum

RTECS #

TP2160000

CAS #

7440-06-4

Updated

September 201

Molecular Weight

195.09

Molecular Formula

Pt

Synonyms

C.I. 77795
Liquid bright platinum
Platin (German)
Platinum (ACGIH)
Platinum Black
Platinum sponge

Tumorigenic Data and References

Route/OrganismDoseEffectReference
implant/mouse lowest published toxic dose: 23 gm/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application		NATWAY 42,75,1955
implant/rat lowest published toxic dose: 5250 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application		NATWAY 42,75,1955

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 17 mg/kgLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Lipids including transport		EKFAE9 57,38,1994

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 9100 mg/kg/26W- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Other proteins		GTPZAB 23(9),4,1979

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 1 mg/m3DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWJJATDK 26,191,2006
TOXICOLOGY REVIEWENTOX* -,448,2005
TOXICOLOGY REVIEWHBTME* ,769,2007
TOXICOLOGY REVIEWNTAPM* -,629,1995

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.002 mg/m3DTLVS* 3,213,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 1 mg/m3, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 1 mg/m3, inhal, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.002 mg(Pt)/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 1 mg/m3 (dust), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 1 mg/m3, NOV2011
Occupational Exposure Limit-FRANCEVME 1 mg/m3, FEB2006
Occupational Exposure Limit-HUNGARYtime-weighted average 1 mg/m3, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 1 mg/m3 (dust), NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 0.002 mg/m3, 2006
Occupational Exposure Limit-KOREAtime-weighted average 1 mg/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.002 mg(Pt)/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 1 mg/m3, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.002 mg/m3, JAN1999
Occupational Exposure Limit-PERUtime-weighted average 1 mg/m3, JUL2005
Occupational Exposure Limit-SWEDENtime-weighted average 1 mg/m3 (total dust), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 1 mg/m3, inhal, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 1 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 5 mg/m3, OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PLATINUM (as Pt), metal-air10H time-weighted average 1 mg/m3NIOSH* DHHS #92-100,1992
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PLATINUM (as Pt), soluble salts-air10H time-weighted average 0.002 mg/m3NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code X4385; Number of Industries 1; Total Number of Facilities 7; Number of Occupations 1; Total Number of Employees Exposed 28; Total Number of Female Employees Exposed 7
National Occupational Exposure Survey 1983Hazard Code X5987; Number of Industries 1; Total Number of Facilities 23; Number of Occupations 1; Total Number of Employees Exposed 23
National Occupational Exposure Survey 1983Hazard Code X7504; Number of Industries 2; Total Number of Facilities 10; Number of Occupations 1; Total Number of Employees Exposed 428; Total Number of Female Employees Exposed 407
National Occupational Exposure Survey 1983Hazard Code 60125; Number of Industries 16; Total Number of Facilities 677; Number of Occupations 26; Total Number of Employees Exposed 22935; Total Number of Female Employees Exposed 3498
National Occupational Hazard Survey 1974Hazard Code 60125; Number of Industries 3; Total Number of Facilities 63; Number of Occupations 4; Total Number of Employees Exposed 680

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Elements by ICP, 7300
NIOSH Analytical Method, 1994: Elements in blood or tissue, 8005
NIOSH Analytical Method, 1994: Metals in urine, 8310
OSHA ANALYTICAL METHOD #ID121

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