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Registry of Toxic Effects of Chemical Substances (RTECS)

Phosphorodithioic acid, S,S'-p-dioxane-2,3-diyl O,O,O',O'-tetraethyl ester

RTECS #

TE3350000

CAS #

78-34-2

Updated

September 201

Molecular Weight

456.56

Molecular Formula

C12H26O6P2S4

Synonyms

1,4-Diossan-2,3-diyl-bis(O,O-dietil-ditiofosfato) (Italian)
1,4-Dioxaan-2,3-diyl-bis(O,O-diethyl-dithiofosfaat) (Dutch)
1,4-Dioxan-2,3-diyl bis(O,O-diethylphosphorothiolothionate)
1,4-Dioxan-2,3-diyl O,O,O',O'-tetraethyl di(phosphoromithioate)
1,4-Dioxan-2,3-diyl-bis(O,O-diaethyl-dithiophosphat) (German)
2,3-p-Dioxandithiol S,S-bis(O,O-diethyl phosphorodithioate)
2,3-p-Dioxane S,S-bis(O,O-diethylphosphorodithioate)
2,3-P-Dioxan-S,S'-bis(O,O-diaethyldithiophosphat) (German)
AC 528
Bis(dithiophosphate de O,O-diethyle) de S,S'-(1,4-dioxanne-2,3-diyle) (French)
Delnatex
Delnav
Deltic
Dioxane phosphate
Dioxathion
Dioxathion (ACGIH)
Dioxation
Dioxothion
ENT 22,897
Hercules 528
Hercules AC528
Kavadel
Navadel
NCI-C00395
p-Dioxane-2,3-dithiol, S,S-diester with O,O-diethyl phosphorodithioate
p-Dioxane-2,3-diyl ethyl phosphorodithioate
Phosphorodithioic acid, S,S'-1,4-dioxane-2,3-diyl O,O,O',O'-tetraethyl ester (9CI)
Ruphos

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in microorganisms/Salmonella typhimurium6667 µg/plate (+enzymatic activation step)ENMUDM 8(Suppl 7),1,1986

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): 340 mg/m3/1HEye: Lacrimation

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Hypermotility, diarrhea		TXAPA9 5,605,1963
inhalation/rat lethal concentration (50 percent kill): 1398 mg/m3/1HEye: Lacrimation

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Hypermotility, diarrhea		TXAPA9 5,605,1963
intraperitoneal/mouse lethal dose (50 percent kill): 33 mg/kgPSEBAA 129,699,1968
intraperitoneal/rat lethal dose (50 percent kill): 30 mg/kgEye: Lacrimation

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Hypermotility, diarrhea		TXAPA9 5,605,1963
oral/chicken lethal dose (50 percent kill): >316 mg/kgEye: Lacrimation

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Changes in structure or function of salivary glands		TXAPA9 5,605,1963
oral/Dog lethal dose (50 percent kill): 10 mg/kgPCOC** -,427,1966
oral/human lowest published toxic dose: 9 mg/kg/60DBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase34ZIAG -,200,1969
oral/mouse lethal dose (50 percent kill): 176 mg/kgEye: Lacrimation

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Hypermotility, diarrhea		TXAPA9 5,605,1963
oral/rat lethal dose (50 percent kill): 20 mg/kgWRPCA2 9,119,1970
skin/rabbit lethal dose (50 percent kill): 85 mg/kgPCOC** -,427,1966
skin/rat lethal dose (50 percent kill): 63 mg/kgEye: Lacrimation

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Hypermotility, diarrhea		TXAPA9 5,605,1963
subcutaneous/chicken lethal dose (50 percent kill): >200 mg/kgEye: Lacrimation

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Hypermotility, diarrhea		TXAPA9 5,605,1963
subcutaneous/rat lethal dose (50 percent kill): 95 mg/kgJEENAI 52,20,1959

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/Dog lowest published toxic dose: 9600 µg/kg/12D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseTXAPA9 5,605,1963
oral/human lowest published toxic dose: 4.2 mg/kg/28D- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase		HBPTO* 1,59,2001
oral/rat lowest published toxic dose: 70980 µg/kg/13W- continuousBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseTXAPA9 5,605,1963

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.1 mg/m3 (inhal, vapor, skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWMUREAV 584,1,2005

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,114,1998
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.2 mg/m3, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.2 mg/m3;KZW 0.4 mg/m3, skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.1 mg/m3 (vapor, aerosol), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.2 mg/m3, skin, MAY2011
Occupational Exposure Limit-FRANCEVME 0.2 mg/m3, Skin, FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 0.2 mg/m3, skin, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 0.2 mg/m3, skin, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.2 mg/m3 (skin), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.2 mg/m3, skin, JAN2002
Occupational Exposure Limit-PERUtime-weighted average 0,1 mg/m3, JUL2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.2 mg/m3, inhal, skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.2 mg/m3, Skin, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIOXATHION-air10H time-weighted average 0.2 mg/m3 (Sk)NIOSH* DHHS #92-100,1992

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,ratNCITR* NCI-TR-125,1978

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