Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

Phosphorodithioic acid, O,O-diethyl S-(2-(ethylthio)ethyl) ester

RTECS #

TD9275000

CAS #

298-04-4

Updated

September 201

Molecular Weight

274.42

Molecular Formula

C8H19O2PS3

Synonyms

BAY 19639
Bayer 19639
Disulfoton
Disulfoton (ACGIH)
Di-syston
Dithiodemeton
Dithiophosphate de O,O-diethyle et de S-(2-ethylthio-ethyle) (French)
Dithiosystox
Dution
Ekatin TD
ENT 23,437
Ethyl thiometon
Ethylthiometon B
Frumin AL
Frumin G
Glebofos
M-74
M-74 (Pesticide)
O,O-Diaethyl-S-(2-aethylthio-aethyl)-dithiophosphat (German)
O,O-Diaethyl-S-(3-thia-pentyl)-dithiophosphat (German)
O,O-Diethyl 2-ethylthioethyl phosphorodithioate
O,O-Diethyl S-(2-eththioethyl) phosphorodithioate
O,O-Diethyl S-(2-eththioethyl) thiothionophosphate
O,O-Diethyl S-(2-ethylmercaptoethyl) dithiophosphate
O,O-Diethyl S-2-(ethylthio)ethyl phosphorodithioate
O,O-Diethyl-S-(2-ethylthio-ethyl)-dithiofosfaat (Dutch)
O,O-Dietil-S-(2-etiltio-etil)-ditiofosfato (Italian)
O,O-Ethyl S-2(ethylthio)ethyl phosphorodithioate
Phosphorodithionic acid, S-2-(ethylthio)ethyl-O,O-diethyl ester
RCRA waste number P039
S-(2-(Ethylthio)ethyl)phosphorothionate
S-2-(Ethylthio)ethyl O,O-diethyl ester of phosphorodithioic acid
Solvirex
Thiodemeton
Vuagt 1-4
Vuagt 1964

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in mammalian somatic cellslymphocyte/mouse40 mg/LNTIS** PB84-138973
mutation in microorganisms/Salmonella typhimurium5720 µg/plate (+enzymatic activation step)MUREAV 28,405,1975
mutation in microorganisms/Salmonella typhimurium5 mg/plate (-enzymatic activation step)MUREAV 116,185,1983
mutation in microorganisms/Escherichia coli5720 µg/plate (-enzymatic activation step)MUREAV 28,405,1975
Unscheduled DNA Synthesisfibroblast/human1 gm/LNTIS** PB80-133226

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/cat Lowest published lethal concentration: 10 mg/m3/4HBehavioral: Tremor

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Dyspnea		GTPZAB 4(9),21,1960
inhalation/rat lethal concentration (50 percent kill): 200 mg/m385GYAV -,25,1971
inhalation/rat lethal concentration (50 percent kill): 180 ppb/1HENTOX* -,85,2005
inhalation/rat lethal concentration (50 percent kill): 90 mg/m3/1HENTOX* -,85,2005
intraperitoneal/guinea pig lethal dose (50 percent kill): 7 mg/kgPeripheral Nerve and Sensation: Fasciculations

Behavioral: Convulsions or effect on seizure threshold

Kidney, Ureter, and Bladder: Urine volume increased		AMIHAB 17,192,1958
intraperitoneal/mouse lethal dose (50 percent kill): 5500 µg/kgPeripheral Nerve and Sensation: Fasciculations

Behavioral: Convulsions or effect on seizure threshold

Kidney, Ureter, and Bladder: Urine volume increased		AMIHAB 17,192,1958
intraperitoneal/rat lethal dose (50 percent kill): 2 mg/kgPeripheral Nerve and Sensation: Fasciculations

Behavioral: Convulsions or effect on seizure threshold

Kidney, Ureter, and Bladder: Urine volume increased		AMIHAB 17,192,1958
intravenous/rat lethal dose (50 percent kill): 5500 µg/kgEye: Lacrimation

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement		13ZGAF -,206,1962
oral/Dog lethal dose (50 percent kill): 5 mg/kgPEMNDP 9,318,1991
oral/duck lethal dose (50 percent kill): 6500 µg/kgDOEAAH 35,25,1979
oral/guinea pig lethal dose (50 percent kill): 10800 µg/kgPeripheral Nerve and Sensation: Fasciculations

Behavioral: Convulsions or effect on seizure threshold

Kidney, Ureter, and Bladder: Urine volume increased		AMIHAB 17,192,1958
oral/mouse lethal dose (50 percent kill): 4800 µg/kgBehavioral: Tremor

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Dyspnea		GTPZAB 4(9),21,1960
oral/quail lethal dose (50 percent kill): 12 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea		EESADV 8,551,1984
oral/rat lethal dose (50 percent kill): 2600 µg/kgYKYUA6 37,717,1986
oral/wild bird lethal dose (50 percent kill): 2400 µg/kgTXAPA9 21,315,1972
oral/woman lowest published toxic dose: 800 µg/kgBehavioral: Hallucinations, distorted perceptions

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Other changes		JJTOEX 8,69,1995
skin/mouse lethal dose (50 percent kill): 15600 µg/kgYKYUA6 37,717,1986
skin/rabbit lowest published lethal dose: 5 mg/kgGTPZAB 2(5),7,1958
skin/rat lethal dose (50 percent kill): 3.6 mg/kgENTOX* -,85,2005
unreported route/chicken lethal dose (50 percent kill): 28 mg/kgFMCHA2 -,C113,1991
unreported route/mouse lethal dose (50 percent kill): 4600 µg/kgGTPZAB 7(5),38,1963
unreported route/rat lethal dose (50 percent kill): 2500 µg/kg30ZDA9 -,369,1971

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lowest published toxic dose: 140 mg/kg/14D- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase		TXAPA9 65,457,1982
intraperitoneal/rat lowest published toxic dose: 60 mg/kg/60D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		AMIHAB 17,192,1958
intraperitoneal/rat lowest published toxic dose: 60 mg/kg/30D- intermittentBehavioral: Change in motor activity (specific assay)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases		FAATDF 20,163,1993
intraperitoneal/rat lowest published toxic dose: 28 mg/kg/14D- intermittentBrain and Coverings: Other degenerative changes

Behavioral: Alteration of operant conditioning

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase		TOLED5 40,47,1988
oral/Dog lowest published toxic dose: 36500 µg/kg/1Y- intermittentBrain and Coverings: Other degenerative changes

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase		TOXID9 42,154,1998
oral/rat lowest published toxic dose: 5460 µg/kg/13W- continuousBrain and Coverings: Other degenerative changes

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase		FAATDF 35,101,1997
oral/rat lowest published toxic dose: 352 mg/kg/20W- continuousBrain and Coverings: Other degenerative changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Metabolism (intermediary): Other		ANYAA9 160,378,1969
oral/rat lowest published toxic dose: 61 mg/kg/9W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldGTPZAB 4(9),21,1960
unreported route/rat lowest published toxic dose: 28 mg/kg/14D- intermittentBrain and Coverings: Other degenerative changesHBPTO* 2,1026,2001

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.05 mg/m3 (inhal, vapor, skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWAQMOAC #73-19,1973
TOXICOLOGY REVIEWMZUZA8 (8),90,1973
TOXICOLOGY REVIEWDTTIAF 80,485,1973
TOXICOLOGY REVIEWRREVAH 63,1,1976
TOXICOLOGY REVIEWENTOX* -,85,2005
TOXICOLOGY REVIEWFEREAC 73,31788,2008
TOXICOLOGY REVIEWFEREAC 73,80317,2008
TOXICOLOGY REVIEWHETOEA 26,321,2007
TOXICOLOGY REVIEWFEREAC 74,46689,2009
TOXICOLOGY REVIEWNBREV* 9,479,1985

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,115,1998
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.1 mg/m3, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.1 mg/m3;KZW 0.2 mg/m3, skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.1 mg/m3, Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.1 mg/m3, skin, MAY2011
Occupational Exposure Limit-FRANCEVME 0.1 mg/m3, FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 0.1 mg/m3, skin, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 0.1 mg/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.1 mg/m3;short term exposure limit 0.3 mg/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.1 mg/m3, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.1 mg/m3, JAN1999
Occupational Exposure Limit-PERUtime-weighted average 0,05 mg/m3, JUL2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.1 mg/m3, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.1 mg/m3, Skin, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DISULFOTON-air10H time-weighted average 0.1 mg/m3 (Sk)NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974Hazard Code T0249; Number of Industries 2; Total Number of Facilities 92; Number of Occupations 2; Total Number of Employees Exposed 165

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/95/264347)
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; E coli polA without S9
EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal; TRP reversion
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Weakly Positive: In vitro UDS-human fibroblast
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Organophosphorus pesticides, 5600
On EPA IRIS database

Follow NIOSH

NIOSH Homepage

TOP