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Registry of Toxic Effects of Chemical Substances (RTECS)

Phosphoramidic acid, isopropyl-, 4-(methylthio)-m-tolyl ethyl ester

RTECS #

TB3675000

CAS #

22224-92-6

Updated

September 201

Molecular Weight

303.39

Molecular Formula

C13H22NO3PS

Synonyms

1-(Methylethyl)-ethyl 3-methyl-4-(methylthio)phenyl phosphoramidate
BAY 68138
BAY sra 3886
ENT 27572
Ethyl 3-methyl-4-(methylthio)phenyl(1-methylethyl)phosphoramidate
Ethyl 4-(methylthio)-m-tolyl isopropylphosphoramidate
Fenamiphos
Fenamiphos (ACGIH)
Isopropylamino-O-ethyl-(4-methylmercapto-3-methylphenyl)phosphate
Nemacur
Nemacur P
NSC 195106
O-Aethyl-O-(3-methyl-4-methylthiophenyl)-isopropylamido-phosphorsaeureester (German)
Phenamiphos
Phosphoramidic acid, (1-methylethyl)-, ethyl (3-methyl-4-(methylthio)phenyl) ester
SRA 3886

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 30 mg/kg (6-15D pregnant)Reproductive: Other effects on femaleTIHEEC 14,869,1998

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): 91 mg/m3/4H85DPAN -,-,1971/1976
oral/cat lethal dose (50 percent kill): 10 mg/kg85DPAN -,-,1971/1976
oral/chicken lethal dose (50 percent kill): 12 mg/kgPEMNDP 9,361,1991
oral/Dog lethal dose (50 percent kill): 10 mg/kg28ZEAL 5,112,1976
oral/domestic bird lethal dose (50 percent kill): 2400 µg/kg85KYAH 11,621,1989
oral/duck lethal dose (50 percent kill): 1680 µg/kgTXAPA9 47,451,1979
oral/mouse lethal dose (50 percent kill): 22700 µg/kg85DPAN -,-,1971/1976
oral/quail lethal dose (50 percent kill): 1 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea		EESADV 8,551,1984
oral/rabbit lethal dose (50 percent kill): 10 mg/kgDTLWS* 4,191,1982
oral/rat lethal dose (50 percent kill): 8 mg/kgBESAAT 15,116,1969
oral/rat lowest published toxic dose: 3.5 mg/kgBehavioral: Tremor

Gastrointestinal: Changes in structure or function of salivary glands

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase		NETEEC 26,407,2004
oral/rat lowest published toxic dose: 7 mg/kgEye: Lacrimation

Behavioral: Change in motor activity (specific assay)

Behavioral: Alteration of classical conditioning		NETEEC 26,407,2004
skin/duck lethal dose (50 percent kill): 24 mg/kgTXAPA9 47,451,1979
skin/rabbit lethal dose (50 percent kill): 178 mg/kgDTLWS* 4,191,1982
skin/rat lethal dose (50 percent kill): 80 mg/kgFMCHA2 -,C216,1991

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.05 mg/m3 (inhal, vapor, skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWRREVAH 63,1,1976
TOXICOLOGY REVIEWMUREAV 562,77,2004
TOXICOLOGY REVIEWFEREAC 73,6867,2008
TOXICOLOGY REVIEWFEREAC 73,53732,2008
TOXICOLOGY REVIEWTOLED5 190,107,2009

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,119,1998
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.1 mg/m3, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.1 mg/m3;KZW 0.2 mg/m3, inhal, skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.1 mg/m3, Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.1 mg/m3, skin, MAY2011
Occupational Exposure Limit-FRANCEVME 0.1 mg/m3, Skin, FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 0.1 mg/m3, skin, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 0.1 mg/m3, skin, 2006
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.1 mg/m3, skin, JAN2002
Occupational Exposure Limit-PERUtime-weighted average 0,1 mg/m3, JUL2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.1 mg/m3, inhal, skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.1 mg/m3, Skin, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO FENAMIPHOS-air10H time-weighted average 0.1 mg/m3 (Sk)NIOSH* DHHS #92-100,1992

Status in Federal Agencies

OrganizationReference
NIOSH Analytical Method, 1994: Organophosphorus pesticides, 5600
On EPA IRIS database

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