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Registry of Toxic Effects of Chemical Substances (RTECS)

Oxalic acid

RTECS #

RO2450000

CAS #

144-62-7

Updated

September 201

Molecular Weight

90.04

Molecular Formula

C2H2O4

Synonyms

Acide oxalique (French)
Acido ossalico (Italian)
Aktisal
Aquisal
Ethanedioic acid
Ethanedionic acid
Kyselina stavelova (Czech)
NCI-C55209
Oxaalzuur (Dutch)
Oxalic acid (ACGIH:OSHA)
Oxalsaeure (German)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 250 µg/24H severe85JCAE -,311,1986
eye /rabbit 100 mg/4S rinse severeFCTOD7 20,573,1982
skin /rabbit 500 mg/24H mild85JCAE -,311,1986

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/mouse 8400 mg/kg (7D male/7D pre-21D pregnant)Reproductive: Effects on fertility: Other measures of fertility

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)		NTIS** PB86-167053
oral/mouse 9.63 gm/kg (7D male/7D prior to copulation/21D pregnant)Reproductive: Effects on fertility: Other measures of fertility

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)		NTIS** #PB86167053
oral/mouse 275 mg/kg (multigenerations)Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)		NTIS** #PB86167053

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 10 mmol/L/24HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 3,189,1989
In Vitro/Non-mammalian species, fibroblast Inhibitor Concentration (50 percent kill): 14.17 mmol/L/24HIn Vitro Toxicity Studies: Cell countingTIVIEQ 7,537,1993
intraperitoneal/mouse lethal dose (50 percent kill): 270 mg/kgTXCYAC 62,203,1990
oral/Dog lowest published lethal dose: 1 gm/kgHBAMAK 4,1377,1935
oral/woman lowest published lethal dose: 600 mg/kgGastrointestinal: Changes in structure or function of esophagus

Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Other changes		YKYUA6 31,959,1980
subcutaneous/cat lowest published lethal dose: 112 mg/kgHBAMAK 4,1377,1935
subcutaneous/frog lowest published lethal dose: 757 mg/kgHBAMAK 4,1377,1935
unreported route/rat lethal dose (50 percent kill): 382 mg/kgHBPTO* 1,824,2001

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat lowest published toxic dose: 225 mg/kg/5D- intermittentLiver: Other changes

Blood: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport		ARTODN 76,269,2002
oral/mouse lowest published toxic dose: 2268 mg/kg/14D- continuousBehavioral: Fluid intakeNTIS** #PB86167053
oral/mouse lowest published toxic dose: 40425 mg/kg/21W- continuousRelated to Chronic Data: Changes in prostate weightNTIS** #PB86167053
oral/rat lowest published toxic dose: 175 gm/kg/70D- continuousEndocrine: Changes in thyroid weight

Musculoskeletal: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		TXAPA9 48,409,1979

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 1 mg/m3;short term exposure limit 2 mg/m3DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWFNSCA6 2,67,1973
TOXICOLOGY REVIEWAINCM* 7,63,2006
TOXICOLOGY REVIEWENTOX* -,320,2005
TOXICOLOGY REVIEWEMCNA* 25,375,2007
TOXICOLOGY REVIEWHUTOX* -,683,1996
TOXICOLOGY REVIEWMUREAV 751,49,2012

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESRED CompletedRBREV* -,329,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 1 mg/m3DTLVS* 3,193,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypttime-weighted average 1 mg/m3, JAN1993
Occupational Exposure Limit-AUSTRALIAtime-weighted average 1 mg/m3, short term exposure limit 2 mg/m3, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 1 mg/m3, inhal, skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 1 mg/m3, short term exposure limit 2 mg/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 1 mg/m3, MAY2011
Occupational Exposure Limit-ECtime-weighted average 1 mg/m3, FEB2006
Occupational Exposure Limit-FINLANDtime-weighted average 1 mg/m3, short term exposure limit 3 mg/m3, skin, NOV2011
Occupational Exposure Limit-FRANCEVME 1 mg/m3, FEB2006
Occupational Exposure Limit-HUNGARYtime-weighted average 1 mg/m3, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 1 mg/m3, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 1 mg/m3, short term exposure limit 2 mg/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 1 mg/m3;short term exposure limit 2 mg/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 1 mg/m3, short term exposure limit 2 ppm, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.01 mg(Ag)/m3, JAN1999
Occupational Exposure Limit-PERUtime-weighted average 1 mg/m3; short term exposure limit 2 mg/m3, JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 1 mg/m3, MAC(short term exposure limit) 2 mg/m3, JAN1999
Occupational Exposure Limit-SWEDENtime-weighted average 1 mg/m3;short term exposure limit 2 mg/m3, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 1 mg/m3, inhal, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 1 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 1 mg/m3;short term exposure limit 2 mg/m3, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 1 mg/m3CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 1 mg/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 1 mg/m3CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 1 mg/m3CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO OXALIC ACID-air10H time-weighted average 1 mg/m3;short term exposure limit 2 mg/m3NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 52480; Number of Industries 75; Total Number of Facilities 6866; Number of Occupations 84; Total Number of Employees Exposed 142000; Total Number of Female Employees Exposed 58727
National Occupational Hazard Survey 1974Hazard Code 52480; Number of Industries 109; Total Number of Facilities 11395; Number of Occupations 66; Total Number of Employees Exposed 180732

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

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