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Registry of Toxic Effects of Chemical Substances (RTECS)

Octane

RTECS #

RG8400000

CAS #

111-65-9

Updated

September 201

Molecular Weight

114.26

Molecular Formula

C8H18

Synonyms

n-Octane
Octane (ACGIH:OSHA)
Oktan (Polish)
Oktanen (Dutch)
Ottani (Italian)

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse Lowest published lethal concentration: 80000 mg/m3/2HVCVGH* -,37,1990
inhalation/rat lethal concentration (50 percent kill): 25260 ppm/4HENTOX* -,291,2005
inhalation/rat lethal concentration (50 percent kill): 118 gm/m3/4HGTPZAB 32(10),23,1988
intravenous/mouse lowest published lethal dose: 428 mg/kgBehavioral: Altered sleep time (including change in righting reflex)APTOA6 37,56,1975

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat lowest published toxic dose: 5 mg/kg/7D- intermittentLiver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases		ENVRAL 22,271,1980

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 300 ppmDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWENTOX* -,291,2005

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 400 ppm (1900 mg/m3)DTLVS* 3,191,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 300 ppm (1400 mg/m3), short term exposure limit 375 ppm (1750 mg/m3), JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 300 ppm (1420 mg/m3), MAR2002
Occupational Exposure Limit-BELGIUMshort term exposure limit 375 ppm (1775 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 200 ppm (935 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 300 ppm (1400 mg/m3), short term exposure limit 380 ppm (1800 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 300 ppm (1450 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 500 ppm (2400 mg/m3), 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 2350 mg/m3, short term exposure limit 9400 mg/m3, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 200 ppm (935 mg/m3), NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 300 ppm (1400 mg/m3), MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 300 ppm (1450 mg/m3), short term exposure limit 375 ppm (1800 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 300 ppm (1450 mg/m3);short term exposure limit 375 ppm (1800 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 300 ppm (1400 mg/m3), short term exposure limit 375 ppm (1750 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 150 ppm (725 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 300 ppm (1401 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 1000 mg/m3, MAC(short term exposure limit) 1800 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 300 ppm, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 200 ppm (900 mg/m3);short term exposure limit 300 ppm (1400 mg/m3), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 300 ppm (1400 mg/m3), KZG-week 600 ppm (2800 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 1450 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 500 ppm (2350 mg/m3), JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 400 ppm (1900 mg/m3), JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 400 ppm (1900 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 500 ppm (2350 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 500 ppm (2350 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 400 ppm (1900 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO OCTANE-air10H time-weighted average 75 ppm;ceiling concentration 385 ppm/15MNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 51705; Number of Industries 22; Total Number of Facilities 1172; Number of Occupations 18; Total Number of Employees Exposed 9186; Total Number of Female Employees Exposed 612
National Occupational Hazard Survey 1974Hazard Code 51705; Number of Industries 5; Total Number of Facilities 95; Number of Occupations 8; Total Number of Employees Exposed 940

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Hydrocarbons, BP 36-126 degree C, 1500
NIOSH Analytical Method, 1996: Volatile organic compound, 2549

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