Registry of Toxic Effects of Chemical Substances (RTECS)
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4,7-Methanoindene, 1,4,5,6,7,8,8-heptachloro-3a,4,7,7a-tetrahydro-
RTECS #
PC0700000CAS #
76-44-8; 23720-59-4; 37229-06-4Updated
September 201Molecular Weight
373.30Molecular Formula
C10H5Cl7Synonyms
1(3a),4,5,6,7,8,8-Heptachloro-3a(1),4,7,7a-tetrahydro-4,7-methanoindene1,4,5,6,7,10,10-Heptachloro-4,7,8,9-tetrahydro-4,7-endomethyleneindene
1,4,5,6,7,10,10-Heptachloro-4,7,8,9-tetrahydro-4,7-methyleneindene
1,4,5,6,7,8,8a-Heptachloro-3a,4,7,7a-tetrahydro-4,7-methanoindane
1,4,5,6,7,8,8-Eptacloro-3a,4,7,7a-tetraidro-4,7-endo-metano-indene (Italian)
1,4,5,6,7,8,8-Heptachloor-3a,4,7,7a-tetrahydro-4,7-endo-methano-indeen (Dutch)
1,4,5,6,7,8,8-Heptachlor-3a,4,7,7,7a-tetrahydro-4,7-endo-methano-inden (German)
1,4,5,6,7,8,8-Heptachloro-3a,4,7,7,7a-tetrahydro-4,7-methylene indene
1,4,5,6,7,8,8-Heptachloro-3a,4,7,7a-tetrahydro-4,7-endomethanoindene
1,4,5,6,7,8,8-Heptachloro-3a,4,7,7a-tetrahydro-4,7-methanoindene
1,4,5,6,7,8,8-Heptachloro-3a,4,7,7a-tetrahydro-4,7-methanol-1H-indene
3,4,5,6,7,8,8a-Heptachlorodicyclopentadiene
3,4,5,6,7,8,8-Heptachlorodicyclopentadiene
3-Chlorochlordene
Aahepta
Agroceres
Analytical grade heptachlor
Arbinex 30TN
Dicyclopentadiene, 3,4,5,6,7,8,8a-heptachloro-
Drinox
E 3314
ENT 15,152
Eptacloro (Italian)
GPKh
H
H-34
H-60
Hepta
Heptachloor (Dutch)
Heptachlor
Heptachlor (ACGIH:OSHA)
Heptachlor (technical grade)
Heptachlorane
Heptachlore (French)
Heptagran
Heptamul
Heptox
Latka 104 (Czech)
NCI-C00180
OMS 193
RCRA waste number P059
Rhodiachlor
Velsicol 104
Velsicol heptachlor
Velsicol104
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| Cytogenetic Analysis | oral/rat | 60 µg/kg | 34LXAP -,555,1976 |
| Cytogenetic Analysis | intraperitoneal/mouse | 5200 µg/kg | SOGEBZ 2,80,1966 |
| Cytogenetic Analysis | fibroblast/hamster | 67.0 µmol/L | MUREAV 608,28,2006 |
| Cytogenetic Analysis | /hamster | 67.0 µmol/L | MUREAV 608,28,2006 |
| Dominant Lethal Test | oral/rat | 60 µg/kg | 34LXAP -,555,1976 |
| morphological transform | embryo/hamster | 10 mg/L | AETODY 1,241,1980 |
| mutation in mammalian somatic cells | lymphocyte/mouse | 25 mg/L | EMMUEG 12,85,1988 |
| other mutation test systems | oral/mouse | 35 mg/kg | MUREAV 343,157,1995 |
| other mutation test systems | /Escherichia coli | 837 µmol/L | EMMUEG 19,98,1992 |
| Unscheduled DNA Synthesis | fibroblast/human | 100 µmol/L | MUREAV 42,161,1977 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/rat | 350 mg/kg (14D prior to copulation) | Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) | PHTOEH 76,112,1995 |
| oral/rat | 3168 mg/kg (70D male) | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Other effects on male Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) | PHTOEH 76,112,1995 |
| oral/rat | 0.51 mg/kg (multigenerations) | Reproductive: Other developmental abnormalities | TOSCF2 60,315,2001 |
| oral/rat | 51 mg/kg (multigenerations) | Reproductive: Specific developmental abnormalities: Central nervous system | TOSCF2 60,315,2001 |
| oral/rat | 30 mg/kg (12-22D pregnant) | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | TOSCF2 61,164,2001 |
| oral/rat | 510 µg/kg (multigenerations) | Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system | TOSCF2 61,164,2001 |
| oral/rat | 51 mg/kg (multigenerations) | Reproductive: Specific developmental abnormalities: Hepatobiliary system | TOSCF2 61,164,2001 |
| oral/rat | 510 µg/kg (multigenerations) | Reproductive: Specific developmental abnormalities: Urogenital system Reproductive: Other developmental abnormalities | TOSCF2 61,164,2001 |
| oral/rat | 45 mg/kg (10D preg-2D after birth) | Reproductive: Other developmental abnormalities | TOXID9 66,131,2002 |
| oral/rat | 99 mg/kg (multigeneration) | Reproductive: Specific developmental abnormalities: Central nervous system | TOXID9 66,131,2002 |
| oral/rat | 50.4 mg/kg (10-21D pregnant) | Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Effects on newborn: Biochemical and metabolic | TOXID9 78,378,2004 |
| oral/mouse | 57 mg/kg (2W pre-21D after birth) | Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Effects on newborn: Biochemical and metabolic | TOXID9 78,378,2004 |
| oral/mouse | 57 mg/kg (14D pre-21D after birth) | Reproductive: Effects on newborn: Biochemical and metabolic | NETOX* 26,721,2005 |
| oral/rat | 25.2 mg/kg (14D prior to copulation) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on fertility: Other measures of fertility | TOXID9 -,238,2008 |
| subcutaneous/rat | 140 mg/kg (14D prior to copulation) | Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) | CBPCBB 110C,221,1995 |
| unreported route/rat | 48 mg/kg (multigeneration) | Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system | TOXID9 72,171,2003 |
Tumorigenic Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/mouse | lowest published toxic dose: 403 mg/kg/80W- continuous | Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors | NCITR* NCI-TR-9,1977 |
| oral/mouse | toxic dose: 930 mg/kg/80W- continuous | Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors | NCITR* NCI-TR-9,1977 |
| oral/mouse | toxic dose: 876 mg/kg/2Y- continuous | Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors | ECEBDI 45,147,1977 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| In Vitro/Mouse, fibroblast | Inhibitor Concentration (10 percent kill): 30 µmol/L/24H | In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc. | TIVIEQ 2,1,1988 |
| In Vitro/Mouse, fibroblast | Inhibitor Concentration (50 percent kill): 59 µmol/L/24H | In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc. | TIVIEQ 2,1,1988 |
| In Vitro/Mouse, fibroblast | Inhibitor Concentration (10 percent kill): 20 µmol/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 2,1,1988 |
| In Vitro/Mouse, fibroblast | Inhibitor Concentration (50 percent kill): 59 µmol/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 2,1,1988 |
| inhalation/cat | Lowest published lethal concentration: 150 mg/m3/4H | 85GMAT -,71,1982 | |
| inhalation/mammal (species unspecified) | Lowest published lethal concentration: 200 mg/m3/4H | Behavioral: Excitement Behavioral: Muscle contraction or spasticity Behavioral: Aggression | GTPZAB 2(5),15,1958 |
| intracerebral/mouse | lethal dose (50 percent kill): 12 mg/kg | Behavioral: Convulsions or effect on seizure threshold | TOLED5 60,289,1992 |
| intraperitoneal/mouse | lethal dose (50 percent kill): 130 mg/kg | SOGEBZ 2,80,1966 | |
| intraperitoneal/rat | lethal dose (50 percent kill): 27 mg/kg | Behavioral: Tremor Behavioral: Convulsions or effect on seizure threshold Behavioral: Change in motor activity (specific assay) | FCTXAV 11,63,1973 |
| intraperitoneal/rat | lowest published toxic dose: 93.3 mg/kg | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Biochemical: Metabolism (intermediary): Other | GEPHDP 18,165,1987 |
| intraperitoneal/rat | lowest published toxic dose: 50 mg/kg | Brain and Coverings: Other degenerative changes Behavioral: Convulsions or effect on seizure threshold Biochemical: Metabolism (intermediary): Other | TOXID9 60,245,2001 |
| intravenous/mouse | lowest published lethal dose: 20 mg/kg | JPETAB 107,266,1953 | |
| oral/cat | lowest published lethal dose: 50 mg/kg | Behavioral: Excitement Behavioral: Muscle contraction or spasticity Behavioral: Aggression | GTPZAB 2(5),15,1958 |
| oral/cat | lethal dose (50 percent kill): 50 mg/kg | VCVGH* -,561,1990 | |
| oral/guinea pig | lethal dose (50 percent kill): 116 mg/kg | PCOC** -,576,1966 | |
| oral/hamster | lethal dose (50 percent kill): 100 mg/kg | EJTXAZ 7,159,1974 | |
| oral/mouse | lethal dose (50 percent kill): 30 mg/kg | ENTOX* -,502,2005 | |
| oral/rat | lethal dose (50 percent kill): 40 mg/kg | PHJOAV 185,361,1960 | |
| oral/rat | lowest published toxic dose: 60 mg/kg | Brain and Coverings: Other degenerative changes | TOXID9 72,304,2003 |
| skin/guinea pig | lowest published lethal dose: 1 gm/kg | Behavioral: Excitement Behavioral: Muscle contraction or spasticity Behavioral: Aggression | GTPZAB 2(5),15,1958 |
| skin/rabbit | lethal dose (50 percent kill): 500 mg/kg | VCVGH* -,561,1990 | |
| skin/rat | lethal dose (50 percent kill): 119 mg/kg | SPEADM 78-1,12,1978 | |
| unreported route/mammal (species unspecified) | lethal dose (50 percent kill): 60 mg/kg | 30ZDA9 -,59,1971 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | lowest published toxic concentration: 1.6 mg/m3/4H/8D- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | VCVGH* -,561,1990 |
| intraperitoneal/mouse | lowest published toxic dose: 18 mg/kg/2W- intermittent | Brain and Coverings: Other degenerative changes Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum | NRTXDN 23,537,2002 |
| intraperitoneal/mouse | lowest published toxic dose: 9 mg/kg/2W- intermittent | Brain and Coverings: Other degenerative changes Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites | NRTXDN 20,631,1999 |
| intraperitoneal/mouse | lowest published toxic dose: 75 mg/kg/3D- intermittent | Brain and Coverings: Other degenerative changes | TOSCF2 61,100,2001 |
| intraperitoneal/mouse | lowest published toxic dose: 6 mg/kg/3D- intermittent | Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum | TOSCF2 61,100,2001 |
| intraperitoneal/mouse | lowest published toxic dose: 150 mg/kg/3D- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | TOSCF2 61,100,2001 |
| intraperitoneal/mouse | lowest published toxic dose: 18 mg/kg/2W- intermittent | Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum | NRTXDN 23,537,2002 |
| intraperitoneal/rat | lowest published toxic dose: 70 mg/kg/7D- intermittent | Liver: Other changes Biochemical: Metabolism (intermediary): Other | TXAPA9 19,234,1971 |
| oral/mammal (species unspecified) | lowest published toxic dose: 2800 mg/kg/28D- continuous | Kidney, Ureter, and Bladder: Changes in bladder weight Endocrine: Changes in adrenal weight Endocrine: Changes in spleen weight | AECTCV 19,913,1990 |
| oral/rabbit | lowest published toxic dose: 0.63 mg/kg/3W- continuous | Immunological Including Allergic: Decreased immune response | HBPTO* 1,771,2001 |
| oral/rat | lowest published toxic dose: 22750 mg/kg/26W- intermittent | Blood: Pigmented or nucleated red blood cells Blood: Changes in erythrocyte (RBC) count Biochemical: Metabolism (intermediary): Lipids including transport | GISAAA 30(3),13,1965 |
| skin/rabbit | lowest published toxic dose: 475 mg/kg/19D- intermittent | Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Respiratory depression Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | GTPZAB 2(5)15,1958 |
| subcutaneous/rat | lowest published toxic dose: 45 mg/kg/18D- intermittent | Endocrine: Estrogenic Endocrine: Other changes | CBPCEE 111C,191,1995 |
| subcutaneous/rat | lowest published toxic dose: 225 mg/kg/18D- intermittent | Endocrine: Effect on menstrual cycle | CBPCEE 111C,191,1995 |
| subcutaneous/rat | lowest published toxic dose: 180 mg/kg/18D- intermittent | Endocrine: Effect on menstrual cycle Nutritional and Gross Metabolic: Weight loss or decreased weight gain | CBCPAI 110C,221,1995 |
| subcutaneous/rat | lowest published toxic dose: 140 mg/kg/14D- intermittent | Reproductive: Maternal effects: Parturition Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) | CBCPAI 110C,221,1995 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 0.05 mg/m3 (skin) | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Confirmed animal carcinogen | DTLVS* TLV/BEI,2013 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Animal Sufficient Evidence | IMEMDT 20,129,1979 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Animal Limited Evidence | IMSUDL 7,146,1987 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Animal Sufficient Evidence | IMEMDT 53,115,1991 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Animal Inadequate Evidence | IMEMDT 5,173,1974 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Human Inadequate Evidence | IMEMDT 20,129,1979 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Human Inadequate Evidence | IMEMDT 53,115,1991 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Group 2B | IMEMDT 53,115,1991 |
| TOXICOLOGY REVIEW | TOLED5 127,101,2002 | |
| TOXICOLOGY REVIEW | CNDQA8 10(3),43,1975 | |
| TOXICOLOGY REVIEW | RREVAH 56,107,1975 | |
| TOXICOLOGY REVIEW | BNYMAM 54,413,1978 | |
| TOXICOLOGY REVIEW | CTOXAO 13,231,1978 | |
| TOXICOLOGY REVIEW | 85CVA2 5,250,1970 | |
| TOXICOLOGY REVIEW | MUTAEX 21,93,2006 | |
| TOXICOLOGY REVIEW | NETOX* 26,531,2005 | |
| TOXICOLOGY REVIEW | ENTOX* -,502,2005 | |
| TOXICOLOGY REVIEW | MUREAV 584,1,2005 | |
| TOXICOLOGY REVIEW | JTEHD6 7,1,2004 | |
| TOXICOLOGY REVIEW | REPTED 23,457,2007 | |
| TOXICOLOGY REVIEW | ITODC* -,327,2004 | |
| TOXICOLOGY REVIEW | HTOPA* 1,501,2002 | |
| TOXICOLOGY REVIEW | MUREAV 590,1,2005 | |
| TOXICOLOGY REVIEW | IMEMDT 79,411, |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION | FEREAC 54,7740,1989 | |
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES | RED Completed | RBREV* -,123,1998 |
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 0.5 mg/m3 (skin) | DTLVS* 3,123,1971 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 0.5 mg/m3, JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 0.5 mg/m3;KZW 5 mg/m3, inhal, skin, 2007 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 0.05 mg/m3, Skin, MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 0.05 mg/m3, skin, carc, MAY2011 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 0.05 mg/m3, short term exposure limit 0.15 mg/m3, skin, NOV2011 | |
| Occupational Exposure Limit-FRANCE | VME 0.03 ppm (0.5 mg/m3), C3 Carcinogen, FEB2006 | |
| Occupational Exposure Limit-GERMANY | MAK 0.05 mg/m3, inhal, skin, 2011 | |
| Occupational Exposure Limit-HUNGARY | Skin, SEP2000 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 0.05 mg/m3, skin, NOV2011 | |
| Occupational Exposure Limit-JAPAN | 2B carc, MAY2012 | |
| Occupational Exposure Limit-KOREA | time-weighted average 0.5 mg/m3, skin, 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 0.5 mg/m3;short term exposure limit 2 mg/m3 (skin), 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 0.5 mg/m3, skin, JAN2002 | |
| Occupational Exposure Limit-PERU | time-weighted average 0,05 mg/m3, JUL2005 | |
| Occupational Exposure Limit-RUSSIA | short term exposure limit 0.01 mg/m3, JUN2003 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 0.05 mg/m3, KZG-week 0.4 mg/m3, carc 3, inhal, skin, JAN2011 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 0.05 mg/m3, Skin, 2003 | |
| Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 0.5 mg/m3, Skin, JAN1993 | |
| Occupational Exposure Limit-TURKEY | time-weighted average 1 mg/m3, Skin, JAN1993 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 0.5 mg/m3 (skin) | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 0.5 mg/m3 (skin) | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 0.5 mg/m3 (skin) | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 0.5 mg/m3 (skin) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO HEPTACHLOR-air | 10H Carcinogen time-weighted average 0.5 mg/m3 (Sk) | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code 35960; Number of Industries 2; Total Number of Facilities 120; Number of Occupations 2; Total Number of Employees Exposed 1034 | |
| National Occupational Hazard Survey 1974 | Hazard Code 35960; Number of Industries 2; Total Number of Facilities 346; Number of Occupations 8; Total Number of Employees Exposed 907 |
Status in Federal Agencies
| Organization | Reference |
|---|---|
| ATSDR TOXICOLOGY PROFILE (NTIS** PB/93/182467/AS) | |
| EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal | |
| EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test | |
| EPA GENETOX PROGRAM 1988, Positive/limited: Carcinogenicity-mouse/rat | |
| EPA TSCA Section 8(d) unpublished health/safety studies | |
| EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
| NCI Carcinogenesis Bioassay (feed);clear evidence:mouse | NCITR* NCI-TR-9,1977 |
| NCI Carcinogenesis Bioassay (feed);no evidence:rat | NCITR* NCI-TR-9,1977 |
| On EPA IRIS database |
- Page last reviewed:March 7, 2014
- Page last updated:February 6, 2017
- Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division