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Registry of Toxic Effects of Chemical Substances (RTECS)

Methane, nitro-

RTECS #

PA9800000

CAS #

75-52-5

Updated

September 201

Molecular Weight

61.05

Molecular Formula

CH3NO2

Synonyms

Nitrocarbol
Nitrometan (Polish)
Nitromethane
Nitromethane (ACGIH:OSHA)

Tumorigenic Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 750 ppm/6H/2Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Eye: Tumors

Liver: Tumors		NTPTR* NTP-TR-461,1997
inhalation/mouse lowest published toxic concentration: 46350 mg/kg/103W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Endocrine: Tumors		NTIS** PB97-205967
inhalation/mouse lowest published toxic concentration: 23175 mg/kg/103W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Endocrine: Tumors		NTIS** PB97-205967
inhalation/rat lowest published toxic concentration: 9656.25 mg/kg/103W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors		NTIS** PB97-205967
inhalation/rat lowest published toxic concentration: 188 ppm/6H/2Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors		NTPTR* NTP-TR-461,1997

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig Lowest published lethal concentration: 5000 ppm/3HJIHTAB 22,315,1940
inhalation/monkey Lowest published lethal concentration: 1000 ppmINMEAF 16,441,1947
inhalation/mouse Lowest published lethal concentration: 18 gm/m3/2H85GMAT -,93,1982
inhalation/rabbit Lowest published lethal concentration: 5000 ppm/6HJIHTAB 22,315,1940
inhalation/rat Lowest published lethal concentration: 12750 mg/m3/1HNTIS** OTS0516767
intraperitoneal/mouse lethal dose (50 percent kill): 110 mg/kgKHFZAN 10(6),53,1976
intraperitoneal/rat lowest published lethal dose: 1500 mg/kgBSPLA9 (1),29,1973
intravenous/Dog lowest published lethal dose: 800 mg/kgLiver: Hepatitis (hepatocellular necrosis), zonal

Lung, Thorax, or Respiration: Respiratory depression		AMIHAB 11,102,1955
intravenous/rabbit lowest published lethal dose: 750 mg/kgAMIHAB 11,102,1955
oral/Dog lowest published lethal dose: 125 mg/kgKidney, Ureter, and Bladder: Changes in both tubules and glomeruli

Liver: Hepatitis (hepatocellular necrosis), zonal		AMIHAB 11,102,1955
oral/mouse lethal dose (50 percent kill): 950 mg/kgGISAAA 32(9),9,1967
oral/rabbit lowest published lethal dose: 750 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory stimulation		JIHTAB 22,315,1940
oral/rat lethal dose (50 percent kill): 940 mg/kgGISAAA 32(9),9,1967
skin/rabbit Lethal dose: >2 gm/kgNTIS** OTS0516767

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 1500 ppm/6H/16D- intermittentBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory stimulation

Liver: Changes in liver weight		NTPTR* NTP-TR-461,1997
inhalation/mouse lowest published toxic concentration: 188 ppm/6H/13W- intermittentOlfaction: Deviated nasal septum

Lung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Changes in bladder weight		NTPTR* NTP-TR-461,1997
inhalation/rat lowest published toxic concentration: 100 ppm/7H/2Y- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainNTIS** OTS0530024
inhalation/rat lowest published toxic concentration: 375 ppm/6H/16D- intermittentPeripheral Nerve and Sensation: Structural change in nerve or sheath

Olfaction: Deviated nasal septum		NTPTR* NTP-TR-461,1997
inhalation/rat lowest published toxic concentration: 1500 ppm/6H/13W- intermittentBlood: Normocytic anemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		NTPTR* NTP-TR-461,1997
oral/rabbit lowest published toxic dose: 2275 mg/kg/26W- intermittentBehavioral: Alteration of classical conditioning

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases		GISAAA 32(9),9,1967
oral/rat lowest published toxic dose: 2275 mg/kg/26W- intermittentBehavioral: Alteration of classical conditioning

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases		GISAAA 32(9),9,1967
oral/rat lowest published toxic dose: 10500 µL/kg/15W- continuousLiver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		AMIHAB 11,102,1955

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 20 ppmDTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed animal carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 77,564,2000
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 77,564,2000
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 77,564,2000
International Agency for Research on Cancer (IARC)Cancer Review:Group 2BIMEMDT 77,564,2000
TOXICOLOGY REVIEWMUREAV 543,201,2003
TOXICOLOGY REVIEWENTOX* -,247,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWMUREAV 566,49,2004
TOXICOLOGY REVIEWMUREAV 682,94,2009

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 100 ppm (250 mg/m3)DTLVS* 3,187,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 20 ppm (50 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 100 ppm (250 mg/m3), skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 20 ppm (51 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 20 ppm (50 mg/m3), carc, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 20 ppm (51 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 100 ppm (250 mg/m3), FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 20 ppm (50 mg/m3), NOV2011
Occupational Exposure Limit-JAPAN2B carc, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 100 ppm (250 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 100 ppm (250 mg/m3);short term exposure limit 150 ppm (375 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 20 ppm (50 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 50 ppm (125 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 20 ppm (50 mg/m3), JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 30 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 20 ppm (50 mg/m3);short term exposure limit 50 ppm (130 mg/m3), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 100 ppm (250 mg/m3), skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 50 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 100 ppm (250 mg/m3), JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 100 ppm (250 mg/m3), JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 100 ppm (254 mg/m3);short term exposure limit 150 ppm (381 mg/m3), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 100 ppm (250 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 100 ppm (250 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 100 ppm (250 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 100 ppm (250 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 50910; Number of Industries 108; Total Number of Facilities 5853; Number of Occupations 92; Total Number of Employees Exposed 134803; Total Number of Female Employees Exposed 46338
National Occupational Hazard Survey 1974Hazard Code 50910; Number of Industries 19; Total Number of Facilities 849; Number of Occupations 22; Total Number of Employees Exposed 14084

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (inhal);clear evidence:mouse,rat
NIOSH Analytical Method, 1994: Nitromethane, 2527
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
NTP Carcinogenesis studies; on test (two year studies), October 2000

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