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Registry of Toxic Effects of Chemical Substances (RTECS)

Isooctyl alcohol

RTECS #

NS7700000

CAS #

26952-21-6

Updated

September 201

Molecular Weight

130.26

Molecular Formula

C8H18O

Synonyms

Exxal 8
Isooctanol
Isooctyl alcohol (ACGIH)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 mg severeAIHAAP 34,493,1973
skin /rabbit 2600 mg/24H moderateAIHAAP 34,493,1973

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
oral/mammal (species unspecified) lethal dose (50 percent kill): 140 mg/kgGISAAA 39(4),86,1974
oral/mouse lethal dose (50 percent kill): 1670 mg/kg85GMAT -,77,1982
oral/rat lethal dose (50 percent kill): 1480 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea		AIHAAP 34,493,1973
skin/rabbit lethal dose (50 percent kill): 2520 mg/kg31ZTAS -,72,1968
unreported route/mammal (species unspecified) lethal dose (50 percent kill): 1670 mg/kgGISAAA 51(5),61,1986

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 1500 µg/m3/24H/96D- continuousBlood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase		GISAAA 37(8),16,1972
inhalation/rat lowest published toxic concentration: 600 mg/m3/6H/2W- intermittentKidney, Ureter, and Bladder: Changes in bladder weight

Endocrine: Changes in spleen weight

Blood: Changes in erythrocyte (RBC) count		NTIS** OTS0570889

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 50 ppm (skin)DTLVS* TLV/BEI,2013

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 50 ppm (266 mg/m3), JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 50 ppm (270 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 50 ppm (270 mg/m3), skin, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 50 ppm (270 mg/m3), short term exposure limit 200 ppm (1100 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 50 ppm (270 mg/m3), Skin, FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 50 ppm (270 mg/m3), skin, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 50 ppm (270 mg/m3), skin, 2006
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 50 ppm (266 mg/m3), skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 25 ppm (135 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 50 ppm (266 mg/m3), JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 50 mg/m3, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 50 ppm (270 mg/m3), skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 270 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 50 ppm (271 mg/m3), OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ISOOCTYL ALCOHOL-air10H time-weighted average 50 ppm (Sk)NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 83573; Number of Industries 17; Total Number of Facilities 752; Number of Occupations 22; Total Number of Employees Exposed 12363; Total Number of Female Employees Exposed 3300
National Occupational Hazard Survey 1974Hazard Code 83573; Number of Industries 6; Total Number of Facilities 160; Number of Occupations 19; Total Number of Employees Exposed 32085

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

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