Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

Hydantoin, 1,3-dichloro-5,5-dimethyl-

RTECS #

MU0700000

CAS #

118-52-5; 55945-60-3

Updated

September 201

Molecular Weight

197.03

Molecular Formula

C5H6Cl2N2O2

Synonyms

1,3-Dichloro-5,5-dimethyl hydantoin
1,3-Dichloro-5,5-dimethyl hydantoin (ACGIH:OSHA)
1,3-Dichloro-5,5-dimethyl-2,4-imidazolidinedione
1,3-Dichloro-5,5-dimethylhydantoin
1,3-Dichloro-5,5'-methylhydantoin
1,3-Dwuchloro-5,5-dwumetylohydantoina (Polish)
2,4-Imidazolidinedione, 1,3-dichloro-5,5-dimethyl- (9CI)
Dactin
Daktin
Dantoin
Dichlorantin
Dwuchlorantyny (Polish)
Halane
Hydan
Hydan (antiseptic)
Hydantoin, dichlorodimethyl-
NCI-C03054
Omchlor

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 500 mg/24H severeEPASR* 8EHQ-0281-0382
skin /rabbit 100 mg/24H severeEPASR* 8EHQ-0281-0382

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
morphological transformembryo/rat6300 ng/plateJJATDK 1,190,1981
sex chromosome loss and nondisjunctionparenteral/Drosophila melanogaster250 ppmENMUDM 7,677,1985

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat Lowest published lethal concentration: 20 gm/m3/1HBehavioral: Tremor

Lung, Thorax, or Respiration: Respiratory stimulation

Gastrointestinal: Changes in structure or function of salivary glands		EPASR* 8EHQ-0281-0382
oral/guinea pig lethal dose (50 percent kill): 1350 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Withdrawal

Lung, Thorax, or Respiration: Dyspnea		GISAAA 47(6),76,1982
oral/rabbit lethal dose (50 percent kill): 1520 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Withdrawal

Lung, Thorax, or Respiration: Dyspnea		GISAAA 47(6),76,1982
oral/rat lethal dose (50 percent kill): 542 mg/kg85INA8 5,183,1986
skin/rabbit lethal dose (50 percent kill): >20 gm/kgEPASR* 8EHQ-0281-0382
unreported route/mammal (species unspecified) lethal dose (50 percent kill): 500 mg/kgGWXXBX #2550828
unreported route/rat lethal dose (50 percent kill): 550 mg/kgBCTKAG 19,52,1986

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 8784 mg/kg/28D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldBCTKAG 19,52,1986
oral/rat lowest published toxic dose: 634 mg/kg/30D- intermittentBrain and Coverings: Recordings from specific areas of CNS

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases		GISAAA 47(6),76,1982

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.2 mg/m3;short term exposure limit 0.4 mg/m3DTLVS* TLV/BEI,2013

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.2 mg/m3DTLVS* 3,78,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.2 mg/m3, short term exposure limit 0.4 mg/m3, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.2 mg/m3;KZW 0.4 mg/m3, inhal, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.2 mg/m3, short term exposure limit 0.4 mg/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.2 mg/m3, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.2 mg/m3, short term exposure limit 0.6 mg/m3, NOV2011
Occupational Exposure Limit-FRANCEVME 0.2 mg/m3, FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 0.2 mg/m3, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 0.2 mg/m3, short term exposure limit 0.4 mg/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.2 mg/m3;short term exposure limit 0.4 mg/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.2 mg/m3; short term exposure limit 0.4 mg/m3, JAN2002
Occupational Exposure Limit-PERUtime-weighted average 0.2 mg/m3; short term exposure limit 0.4 mg/m3, JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 2 mg/m3, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 0.2 mg/m3, inhal, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.2 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.2 mg/m3, JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.2 mg/m3;short term exposure limit 0.4 mg/m3, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.2 mg/m3CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 0.2 mg/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 0.2 mg/m3CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.2 mg/m3CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO THE CHEMICAL-air10H time-weighted average 0.2 mg/m3;short term exposure limit 0.4 mg/m3NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 24100; Number of Industries 9; Total Number of Facilities 436; Number of Occupations 10; Total Number of Employees Exposed 3502; Total Number of Female Employees Exposed 1780
National Occupational Hazard Survey 1974Hazard Code 24100; Number of Industries 5; Total Number of Facilities 729; Number of Occupations 6; Total Number of Employees Exposed 2224

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

Follow NIOSH

NIOSH Homepage

TOP