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Registry of Toxic Effects of Chemical Substances (RTECS)

4-Heptanone

RTECS #

MJ5600000

CAS #

123-19-3

Updated

September 201

Molecular Weight

114.21

Molecular Formula

C7H14O

Synonyms

Butyrone
Dipropyl ketone
Dipropyl ketone (ACGIH)
GBL
Heptan-4-one
Propyl ketone

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 500 mg/24H mild85JCAE -,286,1986
skin /rabbit 500 mg/24H mild85JCAE -,286,1986

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): 2690 ppm/6HBehavioral: Sleep

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression		38MKAJ 2C,4764,1982
intravenous/mouse lowest published lethal dose: 271 mg/kgBehavioral: Altered sleep time (including change in righting reflex)APTOA6 37,56,1975
oral/rat lethal dose (50 percent kill): 3730 µL/kgTXAPA9 28,313,1974
skin/rabbit lethal dose (50 percent kill): 5660 µL/kgTXAPA9 28,313,1974

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 250 gm/m3/5D- intermittentImmunological Including Allergic: Hypersensitivity delayed (multiple organ involvement)TXAPA9 197,280,2004
oral/rat lowest published toxic dose: 30 gm/kg/3W- intermittentBehavioral: Somnolence (general depressed activity)

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		NTIS** OTS0571116
oral/rat lowest published toxic dose: 130 gm/kg/13W- intermittentKidney, Ureter, and Bladder: Changes in bladder weight

Endocrine: Hypoglycemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		NTIS** OTS0571116

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 50 ppmDTLVS* TLV/BEI,2013

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRALIAtime-weighted average 50 ppm (233 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 50 ppm (230 mg/m3);KZW 100 ppm (460 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 50 ppm (236 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 50 ppm (230 mg/m3), MAY2011
Occupational Exposure Limit-FRANCEVME 50 ppm (235 mg/m3), FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 50 ppm (230 mg/m3), NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 50 ppm (235 mg/m3), 2006
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 50 ppm (233 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 25 ppm (115 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 50 ppm (235 mg/m3), JUL2005
Occupational Exposure Limit-SWITZERLANDMAK-week 50 ppm (235 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 235 mg/m3, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIPROPYL KETONE-air10H time-weighted average 50 ppmNIOSH* DHHS #95-121,1995

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

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