Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

3-Heptanone

RTECS #

MJ5250000

CAS #

106-35-4

Updated

September 201

Molecular Weight

114.21

Molecular Formula

C7H14O

Synonyms

3-Heptanone (OSHA)
Aethylbutylketon (German)
Butyl ethyl ketone
Eptan-3-one (Italian)
Ethyl butyl ketone
Ethyl butyl ketone (ACGIH:OSHA)
Ethylbutylcetone (French)
Ethylbutylketon (Dutch)
Etilbutilchetone (Italian)
Heptan-3-on (Dutch, German)
Heptan-3-one
n-Butyl ethyl ketone

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 mg mildFCTXAV 16,731,1978
eye /rabbit 500 mg/24H mild85JCAE -,286,1986
skin /rabbit 500 mg open irritation test mildUCDS** 3/12/1969
skin /rabbit 500 mg/24H moderateFCTXAV 16,731,1978

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat Lowest published lethal concentration: 2000 ppm/4HJIHTAB 31,343,1949
oral/rat lethal dose (50 percent kill): 2760 mg/kgJIHTAB 31,60,1949
skin/rabbit lethal dose (50 percent kill): >20 mL/kgUCDS** 3/12/1969

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 2863 mg/m3/16H/4D- intermittentSpinal Cord: Other degenerative changes

Peripheral Nerve and Sensation: Structural change in nerve or sheath		VCVGK* -,430,1994
oral/rat lowest published toxic dose: 140000 mg/kg/14W- intermittentBrain and Coverings: Other degenerative changes

Spinal Cord: Other degenerative changes

Peripheral Nerve and Sensation: Structural change in nerve or sheath		VCVGK* -,430,1994

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 50 ppm;short term exposure limit 75 ppmDTLVS* TLV/BEI,2013

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 50 ppm (230 mg/m3)DTLVS* 3,105,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 50 ppm (234 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 20 ppm (95 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 20 ppm (95 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 20 ppm (95 mg/m3), MAY2011
Occupational Exposure Limit-ECtime-weighted average 95 mg/m3 (20 ppm), JUN2000
Occupational Exposure Limit-FINLANDtime-weighted average 20 ppm (95 mg/m3), short term exposure limit 75 ppm (360 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 20 ppm (95 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 10 ppm (47 mg/m3), 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 95 mg/m3, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 20 ppm (95 mg/m3), NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 50 ppm (230 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 50 ppm (230 mg/m3);short term exposure limit 75 ppm (345 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 50 ppm (234 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 25 ppm (115 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 50 ppm (234 mg/m3); short term exposure limit 75 ppm (350 mg/m3), JUL2005
Occupational Exposure Limit-SWEDENtime-weighted average 25 ppm (120 mg/m3);short term exposure limit 50 ppm (250 mg/m3), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 10 ppm (47 mg/m3), KZG-week 20 ppm (94 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 163 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 35 ppm (166 mg/m3);short term exposure limit 100 ppm (475 mg/m3), skin, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 50 ppm (230 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 50 ppm (230 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 50 ppm (230 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 50 ppm (230 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ETHYL BUTYL KETONE-air10H time-weighted average 50 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 36330; Number of Industries 20; Total Number of Facilities 2103; Number of Occupations 9; Total Number of Employees Exposed 11318; Total Number of Female Employees Exposed 1164
National Occupational Hazard Survey 1974Hazard Code 36330; Number of Industries 8; Total Number of Facilities 320; Number of Occupations 14; Total Number of Employees Exposed 1923

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Ketones II, 1301

Follow NIOSH

NIOSH Homepage

TOP