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Registry of Toxic Effects of Chemical Substances (RTECS)

Ethylene, bromo-

RTECS #

KU8400000

CAS #

593-60-2

Updated

September 201

Molecular Weight

106.96

Molecular Formula

C2H3Br

Synonyms

Bromoethene
Bromoethene (9CI)
Bromoethylene
Bromure de vinyle (French)
Ethene, bromo-
NCI-C50373
Vinile (bromuro di) (Italian)
Vinyl bromide
Vinyl bromide (ACGIH)
Vinylbromid (German)
Vinyle (bromure de) (French)

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damageoral/mouse2 gm/kgMUREAV 419,13,1998
morphological transforminhalation/rat2000 ppm/14W- intermittentARTODN 47,71,1981
mutation in microorganisms/Salmonella typhimurium2 pph/16H (+/-enzymatic activation step)ARTODN 41,249,1979
sex chromosome loss and nondisjunctioninhalation/Drosophila melanogaster14500 ppmCRNGDP 17,1083,1996
specific locus testinhalation/Drosophila melanogaster54000 ppmCRNGDP 17,1083,1996

Tumorigenic Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 10 ppm/6H/2Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Vascular: Tumors		TXAPA9 64,367,1982
inhalation/rat toxic concentration (other than lowest): 10 ppmTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Blood: Lymphoma including Hodgkin's disease		CHWKA9 123(24),25,1978
inhalation/rat toxic concentration (other than lowest): 52 ppm/6H/2Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Vascular: Tumors		TXAPA9 64,367,1982

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat Lowest published lethal concentration: 50000 ppm/7H85INA8 6,1690,1991
inhalation/rat lowest published toxic concentration: 109000 mg/m3/7HBehavioral: General anestheticVCVGH* -,599,1990
inhalation/rat Lowest published lethal concentration: 219000 mg/m3/7HVCVGH* -,599,1990
oral/rat lethal dose (50 percent kill): 500 mg/kgDOWCC* -,12,1966

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 10000 ppm/7H/4W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainAIHAAP 31,1,1970
inhalation/rat lowest published toxic concentration: 250 ppm/6H/26W- intermittentCardiac: Changes in heart weight

Liver: Changes in liver weight		AIHAAP 31,1,1970

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.5 ppmDTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Suspected human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 39,133,1986
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 71,923,1999
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 39,133,1986
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 71,923,1999
International Agency for Research on Cancer (IARC)Cancer Review: Group 2AIMEMDT 97,454,2008
International Agency for Research on Cancer (IARC)Cancer Review:Group 2AIMEMDT 71,923,1999
TOXICOLOGY REVIEWVHTODE 22,31,1980
TOXICOLOGY REVIEWFCTOD7 44,1699,2006
TOXICOLOGY REVIEWENTOX* -,435,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWMUREAV 654,114,2008

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 250 ppm (1100 mg/m3)DTLWS* 3,31,1972
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 5 ppm (22 mg/m3), Carcinogen, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 5 ppm (22 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 5 ppm (20 mg/m3), carc, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 1 ppm (4.4 mg/m3), NOV2011
Occupational Exposure Limit-HUNGARYceiling concentration 22 mg/m3, Carcinogen, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 5 ppm (20 mg/m3), carc, NOV2011
Occupational Exposure Limit-JAPAN2A carc, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 5 ppm (20 mg/m3), 2006
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 5 ppm (22 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 1 ppm (4 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 0.5 ppm (2.2 mg/m3), JUL2005
Occupational Exposure Limit-SWITZERLANDMAK-week 5 ppm (22 mg/m3), carc 2, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.012 mg/m3, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO VINYL BROMIDE-airCarcinogen lowest feasible concentrationNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 84575; Number of Industries 1; Total Number of Facilities 7; Number of Occupations 1; Total Number of Employees Exposed 1822; Total Number of Female Employees Exposed 272
National Occupational Hazard Survey 1974Hazard Code 84575; Number of Industries 1; Total Number of Facilities 11; Number of Occupations 3; Total Number of Employees Exposed 357

Status in Federal Agencies

OrganizationReference
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULEFEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Vinyl bromide, 1009
NIOSH CURRENT INTELLIGENCE BULLETIN 28, 1978
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
On EPA IRIS database
OSHA ANALYTICAL METHOD #08

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