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Registry of Toxic Effects of Chemical Substances (RTECS)

Ether, 2-chloro-1,1,2-trifluoroethyl difluoromethyl

RTECS #

KN6800000

CAS #

13838-16-9

Updated

September 201

Molecular Weight

184.50

Molecular Formula

C3H2ClF5O

Synonyms

2-Chloro-1-(difluoromethoxy)-1,1,2-trifluoroethane
2-Chloro-1,1,2-trifluoroethyl difluoromethyl ether
Alyrane
Anesthetic Compound No. 347
Compound 347
Efrane
Enflurane
Enflurane (ACGIH)
Ethane, 2-chloro-1-(difluoromethoxy)-1,1,2-trifluoro-
Ethrane
Methylflurether
NSC-115944
OHIO 347

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 mg moderateFEPRA7 35,729,1976

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislymphocyte/human1000 ppmENVRAL 12,366,1976
Cytogenetic Analysisfibroblast/mouse1000 ppmENVRAL 12,366,1976
Cytogenetic Analysisparenteral/chicken10 mgENVRAL 12,366,1976
other mutation test systemsinhalation/rat1 pph/3H-continuousEXPEAM 35,71,1979
sperm morphologyinhalation/mouse12000 ppm/4H/5D- intermittentANESAV 54,53,1981

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 16500 ppm/6H (8-10D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)ANESAV 64,339,1986
inhalation/rat 20 ppm/8H (28D prior to copulation/1-21D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)BJANAD 53,203,1981
inhalation/rat 1500 ppm/6H (1-20D pregnant)Reproductive: Effects on newborn: Other postnatal measures or effectsAIPTAK 256,134,1982
inhalation/rat 16500 ppm/6H (11-13D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemANESAV 64,339,1986
inhalation/mouse 1 pph/4H (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system		TJADAB 19,53A,1979
inhalation/mouse 10000 ppm/4H (6-15D pregnant)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system		ANESAV 54,505,1981
inhalation/mouse 10000 ppm/4H (6-15D pregnant)Reproductive: Specific developmental abnormalities: Urogenital systemANESAV 54,505,1981

Tumorigenic Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 3000 ppm/4H/78W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors		ANESAV 56,9,1982

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/human lowest published toxic concentration: 1 pph/6HKidney, Ureter, and Bladder: Urine volume decreased or anuriaANESAV 45,557,1976
inhalation/human lowest published toxic concentration: 1.2 pph/340MBehavioral: General anesthetic

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases		SIMEJ* 50,73,2009
inhalation/mouse lethal concentration (50 percent kill): 8100 ppm/3HIYKEDH 12,668,1981
inhalation/rat lethal concentration (50 percent kill): 14000 ppm/3HIYKEDH 12,668,1981
intraperitoneal/mouse lethal dose (50 percent kill): 3900 µL/kgLung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes		YKYUA6 32,491,1981
intraperitoneal/mouse lowest published toxic dose: 1.2 mL/kgBehavioral: Altered sleep time (including change in righting reflex)BCLPT* 103,31,2008
intraperitoneal/mouse lowest published toxic dose: 0.6 mL/kgBehavioral: AnalgesiaBCLPT* 103,31,2008
intraperitoneal/rat lethal dose (50 percent kill): 6 mL/kgLung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes		YKYUA6 32,491,1981
oral/mouse lethal dose (50 percent kill): 5 mL/kgLung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes		YKYUA6 32,491,1981
oral/rat lethal dose (50 percent kill): 5450 µL/kgLung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes		YKYUA6 32,491,1981
subcutaneous/mouse lethal dose (50 percent kill): 38800 µL/kgLung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes		YKYUA6 32,491,1981
subcutaneous/rat lethal dose (50 percent kill): 19500 µL/kgLung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes		YKYUA6 32,491,1981

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 170 ppm/3H/4W- intermittentLiver: Other changes

Liver: Changes in liver weight		YKYUA6 32,491,1981

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 75 ppmDTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMSUDL 7,93,1987
TOXICOLOGY REVIEWTPHSDY 23,519,2002
TOXICOLOGY REVIEWDIMON* 39,678,1993
TOXICOLOGY REVIEWENTOX* -,125,2005
TOXICOLOGY REVIEWHUTOX* -,577,1996
TOXICOLOGY REVIEWNCLNA* 16,503,1998
TOXICOLOGY REVIEWNBREV* 5,1,1981

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.5 ppm (3.8 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 20 ppm (150 mg/m3);KZW 80 ppm (600 mg/m3), skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 75 ppm (574 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 2 ppm (15 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 10 ppm (77 mg/m3), short term exposure limit 20 ppm (150 mg/m3), NOV2011
Occupational Exposure Limit-GERMANYMAK 20 ppm (150 mg/m3), 2011
Occupational Exposure Limit-ICELANDtime-weighted average 2 ppm (15 mg/m3), NOV2011
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.5 ppm, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 2 ppm (15 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 75 ppm (566 mg/m3), JUL2005
Occupational Exposure Limit-SWEDENtime-weighted average 10 ppm (80 mg/m3);short term exposure limit 20 ppm (150 mg/m3), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 10 ppm (77 mg/m3), KZG-week 80 ppm (616 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 153 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 50 ppm (383 mg/m3), OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ENFLURANE-airceiling concentration 2 ppm/60MNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code X3127; Number of Industries 2; Total Number of Facilities 2871; Number of Occupations 12; Total Number of Employees Exposed 86214; Total Number of Female Employees Exposed 73439
National Occupational Exposure Survey 1983Hazard Code X9341; Number of Industries 1; Total Number of Facilities 21; Number of Occupations 1; Total Number of Employees Exposed 453; Total Number of Female Employees Exposed 329

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test; Sperm morphology-mouse
EPA GENETOX PROGRAM 1988, Negative: V79 cell culture-gene mutation
OSHA ANALYTICAL METHOD #103
OSHA ANALYTICAL METHOD #29

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