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Registry of Toxic Effects of Chemical Substances (RTECS)

Ether, bis(2,3-epoxypropyl)

RTECS #

KN2350000

CAS #

2238-07-5

Updated

September 201

Molecular Weight

130.16

Molecular Formula

C6H10O3

Synonyms

DGE (OSHA)
Di(2,3-epoxy)propyl ether
Diglycidyl ether
Diglycidyl ether (ACGIH:OSHA)
Ether, diglycidyl

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 113 mg severeAMIHAB 14,250,1956
eye /rabbit 750 µg/24H severe85JCAE -,773,1986
skin /rabbit 563 mg/3D severeAMIHAB 14,250,1956
skin /rabbit 20 mg/24H moderate85JCAE -,773,1986

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in microorganisms/Salmonella typhimurium50 µg/plate (+/-enzymatic activation step)MUREAV 66,367,1979

Tumorigenic Data and References

Route/OrganismDoseEffectReference
unreported route/mouse lowest published toxic dose: 1300 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors		RARSAM 3,193,1963

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): 30 ppm/4HLung, Thorax, or Respiration: Other changesAMIHAB 14,250,1956
inhalation/rat lethal concentration (50 percent kill): 200 ppm/4H85JCAE -,773,1986
intravenous/mouse lethal dose (50 percent kill): 100 mg/kgCSLNX* NX#00108
intravenous/rabbit lowest published lethal dose: 200 mg/kgLung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Liver: Hepatitis (hepatocellular necrosis), diffuse		AEHLAU 2,31,1961
oral/mouse lethal dose (50 percent kill): 170 mg/kgBrain and Coverings: Recordings from specific areas of CNS

Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia		AMIHAB 14,250,1956
oral/rat lethal dose (50 percent kill): 450 mg/kgBrain and Coverings: Recordings from specific areas of CNS

Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia		AMIHAB 14,250,1956
skin/rabbit lowest published lethal dose: 1500 mg/kgEye: Lacrimation

Behavioral: Somnolence (general depressed activity)

Skin: After systemic exposure: Dermatitis, irritative		AMIHAB 14,250,1956
skin/rat lethal dose (50 percent kill): 1 gm/kg85JCAE -,773,1986

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 2 ppm/4H/29D- intermittentEndocrine: Changes in spleen weight

Endocrine: Changes in thymus weight

Blood: Changes in leukocyte (WBC) count		AEHLAU 2,31,1961
skin/rat lowest published toxic dose: 2500 mg/kg/4W- intermittentBlood: Changes in bone marrow not included in above

Blood: Changes in leukocyte (WBC) count

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		AEHLAU 2,31,1961

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.01 ppmDTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARDair-ceiling concentration 0.5 ppm (2.8 mg/m3)DTLVS* 3,86,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.1 ppm (0.53 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.1 ppm (0.6 mg/m3);KZW 0.2 ppm (1.2 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.1 ppm (0.54 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.1 ppm (0.53 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDshort term exposure limit 0.2 ppm (1.1 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 0.1 ppm (0.5 mg/m3), FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 0.1 ppm (0.53 mg/m3), short term exposure limit 0.2 ppm (1.1 mg/m3), sen, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 0.1 ppm (0.5 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.1 ppm (0.5 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.1 ppm (0.53 mg/m3), JAN2002
Occupational Exposure Limit-PERUtime-weighted average 0,1 ppm (0,53 mg/m3), JUL2005
Occupational Exposure Limit-SWEDENceiling concentration 0.2 ppm (1.1 mg/m3), Sen, JUN2005
Occupational Exposure Limit-SWITZERLANDceiling concentration 0.1 ppm (0.5 mg/m3), carc 3, skin, JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 0.5 ppm (2.8 mg/m3), JAN1993
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.5 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.5 ppm (2.8 mg/m3), JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 0.5 ppm (2.8 mg/m3), JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)ceiling concentration 0.5 ppm (2.8 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)ceiling concentration 0.5 ppm (2.8 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)ceiling concentration 0.5 ppm (2.8 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)ceiling concentration 0.5 ppm (2.8 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIGLYCIDYL ETHER-air10H Carcinogen time-weighted average 0.1 ppmNIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974Hazard Code 12846; Number of Industries 1; Total Number of Facilities 29; Number of Occupations 1; Total Number of Employees Exposed 86

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Positive: N crassa-reversion
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULEFEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 29, 1978

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