Registry of Toxic Effects of Chemical Substances (RTECS)
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Ethanol, 2-amino-
RTECS #
KJ5775000CAS #
141-43-5Updated
September 201Molecular Weight
61.10Molecular Formula
C2H7NOSynonyms
2-Aminoaethanol (German)2-Aminoetanolo (Italian)
2-Aminoethanol (OSHA)
2-Hydroxyethylamine
Aethanolamin (German)
beta-Aminoethyl alcohol
beta-Ethanolamine
beta-Hydroxyethylamine
Colamine
Etanolamina (Italian)
Ethanolamine
Ethanolamine (ACGIH:OSHA)
Ethylolamine
Glycinol
Kolamin (Czech)
Monoaethanolamin (German)
Monoethanolamine
Olamine
Thiofaco M-50
USAF EK-1597
Skin and Eye Irritation and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| eye /rabbit | 250 µg | severe | AJOPAA 29,1363,1946 |
| skin /mammal (species unspecified) | 5% | TPKVAL 4,81,1962 | |
| skin /rabbit | 505 mg open irritation test | moderate | UCDS** 1/13/1972 |
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| Cytogenetic Analysis | lymphocyte/human | 100 µmol/L | BZARAZ 39,422,1986 |
| sister chromatid exchange | lymphocyte/human | 1 mmol/L | CYGEDX 21(6),29,1987 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/rat | 500 mg/kg (6-15D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Effects on embryo or fetus: Fetal death Reproductive: Specific developmental abnormalities: Musculoskeletal system | TCMUD8 6,403,1986 |
| oral/rat | 500 mg/kg (6-15D pregnant) | Reproductive: Specific developmental abnormalities: Urogenital system | TCMUD8 6,403,1986 |
| oral/rat | 4500 mg/kg (6-15D pregnant) | Reproductive: Other effects on female | FAATDF 40,158,1997 |
| skin/rat | 2250 mg/kg (6-15D pregnant) | Reproductive: Other effects on female | FAATDF 31,117,1996 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| In Vitro/Human, liver tumor | Inhibitor Concentration (50 percent kill): 8.7 mmol/L/24H | In Vitro Toxicity Studies: Cell protein synthesis | TIVIEQ 3,189,1989 |
| inhalation/cat | lowest published toxic concentration: 0.1 gm/m3 | Behavioral: Alteration of classical conditioning Behavioral: Alteration of operant conditioning | TPKVAL 4,81,1962 |
| inhalation/cat | Lethal concentration: >2420 mg/m3/2H | GTPZAB 23(9),55,1979 | |
| inhalation/mouse | Lethal concentration: >2420 mg/m3/2H | GTPZAB 23(9),55,1979 | |
| intramuscular/rat | lethal dose (50 percent kill): 1750 mg/kg | GTPZAB 23(9),55,1979 | |
| intraperitoneal/mouse | lethal dose (50 percent kill): 50 mg/kg | USXXAM #6582498 | |
| intraperitoneal/rat | lethal dose (50 percent kill): 67 mg/kg | TOVEFN (5),45,1994 | |
| intravenous/rat | lethal dose (50 percent kill): 225 mg/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Muscle contraction or spasticity Lung, Thorax, or Respiration: Dyspnea | KBMEAL (4),44,1968 |
| ocular/rabbit | lowest published toxic dose: 100 pph | Eye: Miosis (pupilliary constriction) Eye: Conjunctiva irritation Eye: Corneal damage | TPKVAL 4,81,1962 |
| oral/guinea pig | lethal dose (50 percent kill): 620 mg/kg | EVSSAV 2,289,1968 | |
| oral/mammal (species unspecified) | lowest published lethal dose: 1400 mg/kg | NTIS** OTS0520710 | |
| oral/mouse | lethal dose (50 percent kill): 700 mg/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Muscle contraction or spasticity Lung, Thorax, or Respiration: Dyspnea | TPKVAL 4,81,1962 |
| oral/mouse | lowest published lethal dose: 500 mg/kg | Liver: Fatty liver degeneration Liver: Other changes Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) | TPKVAL 4,81,1962 |
| oral/rabbit | lethal dose (50 percent kill): 1 gm/kg | GTPZAB 23(9),55,1979 | |
| oral/rat | lethal dose (50 percent kill): 1720 mg/kg | TXAPA9 42,417,1977 | |
| skin/rabbit | lethal dose (50 percent kill): 1 mL/kg | UCDS** 1/13/1972 | |
| subcutaneous/rat | lethal dose (50 percent kill): 1500 mg/kg | GTPZAB 23(9),55,1979 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/Dog | lowest published toxic concentration: 102 ppm/24H/30D- continuous | Behavioral: Somnolence (general depressed activity) Skin: After systemic exposure: Dermatitis, irritative Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | AIHAAP 21,374,1960 |
| inhalation/guinea pig | lowest published toxic concentration: 75 ppm/24H/24D- continuous | Behavioral: Somnolence (general depressed activity) Skin: After systemic exposure: Dermatitis, irritative Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | AIHAAP 21,374,1960 |
| inhalation/rat | lowest published toxic concentration: 0.3 gm/m3/0.5Y- intermittent | Lung, Thorax, or Respiration: Respiratory depression Liver: Liver function tests impaired Kidney, Ureter, and Bladder: Proteinuria | TPKVAL 4,81,1962 |
| inhalation/rat | lowest published toxic concentration: 66 ppm/24H/30D- continuous | Behavioral: Somnolence (general depressed activity) Skin: After systemic exposure: Dermatitis, irritative Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | AIHAAP 21,374,1960 |
| inhalation/rat | lowest published toxic concentration: 300 mg/m3/5H/26W- intermittent | Kidney, Ureter, and Bladder: Proteinuria Kidney, Ureter, and Bladder: Other changes in urine composition Nutritional and Gross Metabolic: Weight loss or decreased weight gain | GTPZAB 23(9),55,1979 |
| oral/rat | lowest published toxic dose: 115 gm/kg/90D- continuous | Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in bladder weight Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | NTIS** OTS0516797 |
| oral/rat | lowest published toxic dose: 105 mg/kg/30W- intermittent | Liver: Liver function tests impaired Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | GISAAA 29(2),9,1964 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 3 ppm;short term exposure limit 6 ppm | DTLVS* TLV/BEI,2013 |
| TOXICOLOGY REVIEW | ENTOX* -,266,2005 | |
| TOXICOLOGY REVIEW | TXAPA9 243,239,2010 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION | FEREAC 54,7740,1989 | |
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES | Cancelled | RBREV* -,308,1998 |
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 3 ppm (6 mg/m3) | DTLVS* 3,100,1971 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-ARAB Republic of Egypt | time-weighted average 3 ppm (6 mg/m3), JAN1993 | |
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 3 ppm (7.5 mg/m3), short term exposure limit 6 ppm (15 mg/m3), JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 1 ppm (2.5 mg/m3);KZW 3 ppm (7.6 mg/m3), skin, 2007 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 1 ppm (2.5 mg/m3), MAR2002 | |
| Occupational Exposure Limit-BELGIUM | short term exposure limit 3 ppm (7.6 mg/m3), Skin, MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 1 ppm (2.5 mg/m3), skin, MAY2011 | |
| Occupational Exposure Limit-EC | time-weighted average 2.5 mg/m3 (1 ppm);short term exposure limit 7.6 mg/m3 (3 ppm), skin, FEB2006 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 1 ppm (2.5 mg/m3), short term exposure limit 3 ppm (7.6 mg/m3), skin, NOV2011 | |
| Occupational Exposure Limit-FRANCE | VME 3 ppm (8 mg/m3), FEB2006 | |
| Occupational Exposure Limit-GERMANY | MAK 2 ppm (5.1 mg/m3), skin, 2011 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 1 ppm (2.5 mg/m3), short term exposure limit 3 ppm (7.6 mg/m3), skin, NOV2011 | |
| Occupational Exposure Limit-JAPAN | Occupational Exposure Limit 3 ppm (7.5 mg/m3), MAY2012 | |
| Occupational Exposure Limit-KOREA | time-weighted average 3 ppm (8 mg/m3), short term exposure limit 6 ppm (15 mg/m3), 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 3 ppm (8 mg/m3), 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 3 ppm (7.5 mg/m3); short term exposure limit 6 ppm (15 mg/m3), JAN2002 | |
| Occupational Exposure Limit-NORWAY | time-weighted average 3 ppm (8 mg/m3), JAN1999 | |
| Occupational Exposure Limit-PERU | time-weighted average 3 ppm (7.5 mg/m3); short term exposure limit 6 ppm (15 mg/m3), JUL2005 | |
| Occupational Exposure Limit-POLAND | time-weighted average 3 mg/m3, short term exposure limit 10 mg/m3, JAN1999 | |
| Occupational Exposure Limit-RUSSIA | short term exposure limit 0.5 mg/m3, Skin, JUN2003 | |
| Occupational Exposure Limit-SWEDEN | time-weighted average 3 ppm (8 mg/m3);short term exposure limit 6 ppm (15 mg/m3), Skin, JUN2005 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 2 ppm (5 mg/m3), KZG-week 4 ppm (10 mg/m3), sen, JAN2011 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 2.5 mg/m3, Skin, 2003 | |
| Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 3 ppm (6 mg/m3), JAN1993 | |
| Occupational Exposure Limit-UNITED KINGDOM | time-weighted average 1 ppm (2.5 mg/m3);short term exposure limit 3 ppm (7.6 mg/m3), skin, OCT2007 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 3 ppm (6 mg/m3) | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 3 ppm (6 mg/m3) | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 3 ppm (6 mg/m3) | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 3 ppm (6 mg/m3) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ETHANOLAMINE-air | 10H time-weighted average 3 ppm;short term exposure limit 6 ppm | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code 04980; Number of Industries 274; Total Number of Facilities 56219; Number of Occupations 190; Total Number of Employees Exposed 1163087; Total Number of Female Employees Exposed 328648 | |
| National Occupational Hazard Survey 1974 | Hazard Code 04980; Number of Industries 201; Total Number of Facilities 33147; Number of Occupations 144; Total Number of Employees Exposed 499260 |
Status in Federal Agencies
- Page last reviewed:March 7, 2014
- Page last updated:February 6, 2017
- Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division