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Registry of Toxic Effects of Chemical Substances (RTECS)

Ethane, nitro-

RTECS #

KI5600000

CAS #

79-24-3

Updated

September 201

Molecular Weight

75.08

Molecular Formula

C2H5NO2

Synonyms

Nitroetan (Polish)
Nitroethane
Nitroethane (ACGIH:OSHA)

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig Lowest published lethal concentration: 10000 ppm/3HJIHTAB 22,315,1940
inhalation/mouse Lowest published lethal concentration: 19500 mg/m3/2H85GMAT -,93,1982
inhalation/rabbit Lowest published lethal concentration: 5000 ppm/2HJIHTAB 22,315,1940
inhalation/rat Lowest published lethal concentration: 13000 ppm/6H85INA8 6,1105,1991
intraperitoneal/mouse lethal dose (50 percent kill): 310 mg/kgKHFZAN 10(6),53,1976
intraperitoneal/rat lowest published lethal dose: 1600 mg/kgBlood: Methemoglobinemia- CarboxhemoglobinemiaBSPLA9 (4),137,1972
oral/child lowest published toxic dose: 1478 µL/kgLung, Thorax, or Respiration: Respiratory obstruction

Lung, Thorax, or Respiration: Cyanosis

Blood: Methemoglobinemia- Carboxhemoglobinemia		JTCTDW 32,321,1994
oral/mouse lethal dose (50 percent kill): 860 mg/kgBehavioral: General anesthetic

Behavioral: Tremor

Behavioral: Excitement		GISAAA 32(9),9,1967
oral/rabbit lowest published lethal dose: 500 mg/kgBehavioral: Muscle weakness

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory stimulation		JIHTAB 22,315,1940
oral/rat lethal dose (50 percent kill): 1100 mg/kgBehavioral: General anesthetic

Behavioral: Tremor

Behavioral: Excitement		GISAAA 32(9),9,1967

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 2000 ppm/6H/4D- intermittentBehavioral: Hallucinations, distorted perceptions

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		NTIS** OTS0539250
inhalation/mouse lowest published toxic concentration: 1000 ppm/6H/13W- intermittentOlfaction: Other olfaction effects

Liver: Other changes

Blood: Methemoglobinemia- Carboxhemoglobinemia		NTIS** OTS0539250
inhalation/rat lowest published toxic concentration: 2000 ppm/6H/4D- intermittentBehavioral: Hallucinations, distorted perceptions

Skin and Appendages: Other: Hair

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		NTIS** OTS0539250
inhalation/rat lowest published toxic concentration: 1000 ppm/6H/13W- intermittentLung, Thorax, or Respiration: Cyanosis

Blood: Methemoglobinemia- Carboxhemoglobinemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		NTIS** OTS0539250

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 100 ppmDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWENTOX* -,240,2005
TOXICOLOGY REVIEWHUTOX* -,683,1996

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 100 ppm (310 mg/m3)DTLVS* 3,185,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 100 ppm (307 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 100 ppm (310 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 100 ppm (311 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 100 ppm (310 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 100 ppm (310 mg/m3), short term exposure limit 150 ppm (470 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 100 ppm (310 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 100 ppm (310 mg/m3), 2011
Occupational Exposure Limit-ICELANDtime-weighted average 100 ppm (310 mg/m3), NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 100 ppm (310 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 100 ppm (310 mg/m3);short term exposure limit 150 ppm (465 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 100 ppm (307 mg/m3), JAN2002
Occupational Exposure Limit-PERUtime-weighted average 100 ppm (307 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 30 mg/m3, MAC(short term exposure limit) 240 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 30 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 20 ppm (60 mg/m3);short term exposure limit 50 ppm (150 mg/m3), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 100 ppm (310 mg/m3), KZG-week 400 ppm (1240 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 60 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 100 ppm (310 mg/m3), JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 100 ppm (310 mg/m3), JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 100 ppm (310 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 100 ppm (310 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 100 ppm (310 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 100 ppm (310 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO NITROETHANE-air10H time-weighted average 100 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 50795; Number of Industries 8; Total Number of Facilities 109; Number of Occupations 10; Total Number of Employees Exposed 6001; Total Number of Female Employees Exposed 1652

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Nitroethane, 2526

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