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Registry of Toxic Effects of Chemical Substances (RTECS)

Ethane, 2,2-difluoro-1,1,1,2-tetrachloro-

RTECS #

KI1425000

CAS #

76-11-9

Updated

September 201

Molecular Weight

203.82

Molecular Formula

C2Cl4F2

Synonyms

1,1,1,2-Tetrachloro-2,2-difluoroethane
1,1,1,2-Tetrachloro-2,2-difluoroethane (ACGIH:OSHA)
1,1-Difluoro-1,2,2,2-tetrachloroethane
1,1-Difluoroperchloroethane
CFC 112a
F 112a
Halocarbon 112a
R 112a
Refrigerant 112a

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse Lowest published lethal concentration: 40000 mg/m3/2HVCVGH* -,634,1990
inhalation/mouse lethal concentration (50 percent kill): 123000 mg/m3/2HVCVGH* -,634,1990
inhalation/rat lowest published toxic concentration: 84000 mg/m3Behavioral: General anestheticVCVGH* -,634,1990
inhalation/rat lethal concentration (50 percent kill): 125000 mg/m3/4HVCVGH* -,634,1990
inhalation/rat Lowest published lethal concentration: 258000 mg/m3/40MVCVGH* -,634,1990
inhalation/rat Lowest published lethal concentration: 20000 ppm/30MBehavioral: General anesthetic

Behavioral: Somnolence (general depressed activity)

Liver: Other changes		TXAPA9 19,1,1971
oral/rat lethal dose (50 percent kill): >8 gm/kgNATUAS 210,744,1966

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 100 gm/kg/10D- intermittentBehavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Liver: Changes in liver weight		VCVGH* -,635,1990

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 100 ppmDTLVS* TLV/BEI,2013

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 500 ppm (4170 mg/m3)DTLVS* 3,249,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 500 ppm (4170 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 500 ppm (4170 mg/m3);KZW 1000 ppm (8340 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 500 ppm (4231 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 500 ppm (4170 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 500 ppm (4200 mg/m3), short term exposure limit 630 ppm (5300 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 500 ppm (4170 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 200 ppm (1700 mg/m3), 2011
Occupational Exposure Limit-ICELANDtime-weighted average 500 ppm (4170 mg/m3), NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 500 ppm (4170 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 500 ppm (4170 mg/m3);short term exposure limit 626 ppm (5210 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 500 ppm (4170 mg/m3), JAN2002
Occupational Exposure Limit-SWITZERLANDMAK-week 500 ppm (4200 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 4170 mg/m3, 2003
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 500 ppm (4170 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 500 ppm (4170 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 500 ppm (4170 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 500 ppm (4170 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 1,1,1,2-TETRACHLORO-2,2-DIFLUOROETHANE-airtime-weighted average 500 ppmNIOSH* DHHS #92-100,1992

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: 1,1,1,2-Tetrachloro-2,2-difluoroethane, 1016
NIOSH Analytical Method, 1996: 1,1,2,2-Tetrachloro-1,2-difluoroethane, 1016

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