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Registry of Toxic Effects of Chemical Substances (RTECS)

1,2-Ethanediamine

RTECS #

KH8575000

CAS #

107-15-3

Updated

September 201

Molecular Weight

60.12

Molecular Formula

C2H8N2

Synonyms

1,2-Diaminoaethan (German)
1,2-Diamino-ethaan (Dutch)
1,2-Diaminoethane (OSHA)
1,2-Diamino-ethano (Italian)
1,2-Ethylenediamine
Aethaldiamin (German)
Aethylenediamin (German)
Dimethylenediamine
Ethyleendiamine (Dutch)
Ethylendiamine
Ethylenediamine
Ethylenediamine (ACGIH:OSHA)
Ethylene-diamine (French)
NCI-C60402

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 750 µg severeAJOPAA 29,1363,1946
eye /rabbit 750 µg/24H severe85JCAE -,440,1986
skin /rabbit 450 mg open irritation test moderateUCDS** 12/15/1971
skin /rabbit 10 mg/24H open irritation test severeAMIHBC 4,119,1951

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in microorganisms/Salmonella typhimurium33 µg/plate (+enzymatic activation step)ENMUDM 5(Suppl 1),3,1983

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/mouse 3200 mg/kg (6-13D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)TCMUD8 7,29,1987

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/human lowest published toxic concentration: 200 ppmPeripheral Nerve and Sensation: ParesthesiaAMIHBC 9,223,1954
inhalation/mouse lethal concentration (50 percent kill): 300 mg/m385GMAT -,66,1982
inhalation/rat Lowest published lethal concentration: 4000 ppm/8HAMIHBC 4,119,1951
intraperitoneal/mouse lethal dose (50 percent kill): 200 mg/kgCHTPBA 4,136,1969
intraperitoneal/rat lethal dose (50 percent kill): 76 mg/kgTXAPA9 21,454,1972
intravenous/Dog lowest published lethal dose: 100 mg/kgHBAMAK 4,1295,1935
oral/guinea pig lethal dose (50 percent kill): 470 mg/kgBehavioral: Somnolence (general depressed activity)

Gastrointestinal: Other changes

Kidney, Ureter, and Bladder: Other changes		JIHTAB 23,259,1941
oral/mouse lethal dose (50 percent kill): 1 gm/kgBehavioral: AtaxiaMTPEEI (1),38,1997
oral/rat lethal dose (50 percent kill): 1200 mg/kgBehavioral: AtaxiaMTPEEI (1),38,1997
skin/rabbit lethal dose (50 percent kill): 730 µL/kgAMIHBC 4,119,1951
subcutaneous/rabbit lowest published lethal dose: 500 mg/kgHBAMAK 4,1295,1935
subcutaneous/rat lethal dose (50 percent kill): 300 mg/kg85GMAT -,66,1982

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic dose: 700 µg/m3/17W- intermittentBrain and Coverings: Other degenerative changes

Blood: Changes in spleen

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases		VMDKAM 38(2),1932
inhalation/rat lowest published toxic concentration: 225 ppm/7H/30D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		AMIHBC 9,223,1954
oral/rabbit lowest published toxic dose: 1400 mg/kg/14D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTIS** #PB93-190056
oral/rat lowest published toxic dose: 540 mg/kg/6W- intermittentLung, Thorax, or Respiration: Changes in lung weight

Liver: Liver function tests impaired

Kidney, Ureter, and Bladder: Other changes in urine composition		MTPEEI (1),38,1997
oral/rat lowest published toxic dose: 3500 mg/kg/7D- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		NTIS** OTS0571059
oral/rat lowest published toxic dose: 39 gm/kg/13W- intermittentEye: Other eye effects

Blood: Hemorrhage

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		NTIS** OTS0536438

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 10 ppm (skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWJJOMDZ 15,808,1973
TOXICOLOGY REVIEWCHHSA* 9,6,2002
TOXICOLOGY REVIEWHUTOX* -,649,1996
TOXICOLOGY REVIEWDERCL* 27,289,2009
TOXICOLOGY REVIEWTXAPA9 243,225,2010

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,308,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 10 ppm (25 mg/m3)DTLVS* 3,109,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 10 ppm (25 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 10 ppm (25 mg/m3);KZW 40 ppm (100 mg/m3), skin, sen, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 10 ppm (25 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 10 ppm (25 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 10 ppm (25 mg/m3), short term exposure limit 20 ppm (50 mg/m3), skin, NOV2011
Occupational Exposure Limit-FRANCEVME 10 ppm (25 mg/m3), VLE 15 ppm (35 mg/m3), FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 10 ppm (25 mg/m3), sen, NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 10 ppm (25 mg/m3), skin, a2 sen, s2 sen, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 10 ppm (25 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 10 ppm (25 mg/m3);short term exposure limit 3 mg/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 10 ppm (25 mg/m3), skin, sen, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 10 ppm (25 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 10 ppm (25 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 2 mg/m3, MAC(short term exposure limit) 6 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 2 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 10 ppm (25 mg/m3);short term exposure limit 15 ppm (35 mg/m3), Sen, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 10 ppm (25 mg/m3), KZG-week 20 ppm (50 mg/m3), sen, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 18 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 10 ppm (25 mg/m3), JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 10 ppm (25 mg/m3), JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 10 ppm (25 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 10 ppm (25 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 10 ppm (25 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 10 ppm (25 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ETHYLENEDIAMINE-air10H time-weighted average 10 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 32220; Number of Industries 77; Total Number of Facilities 6260; Number of Occupations 85; Total Number of Employees Exposed 113007; Total Number of Female Employees Exposed 29888
National Occupational Hazard Survey 1974Hazard Code 32220; Number of Industries 33; Total Number of Facilities 2126; Number of Occupations 35; Total Number of Employees Exposed 15918

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: CHO gene mutation
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Ethylenediamine, 2540
On EPA IRIS database
OSHA ANALYTICAL METHOD #ID-60

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