Registry of Toxic Effects of Chemical Substances (RTECS)
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Dimethylamine, N-nitroso-
RTECS #
IQ0525000CAS #
62-75-9Updated
December 2013Molecular Weight
74.10Molecular Formula
C2H6N2OSynonyms
Dimethylnitrosamin (German)Dimethylnitrosamine
Dimethylnitrosoamine
Dimethylnitrosoamine (OSHA)
DMN
DMNA
Methanamine, N-methyl-N-nitroso- (9CI)
N,N-Dimethylnitrosamine
NDMA
Nitrosodimethylamine
N-Methyl-N-nitrosomethanamine
N-Nitrosodimethylamine
N-Nitrosodimethylamine (ACGIH:OSHA)
N-Nitroso-N,N-dimethylamine
RCRA waste number P082
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| body fluid assay | ovary/rat | 320 mg/kg | MUREAV 143,263,1985 |
| Cytogenetic Analysis | embryo/hamster | 100 mmol/L | PJABDW 56,41,1980 |
| Cytogenetic Analysis | intraperitoneal/hamster | 20 mg/kg | CGCYDF 10,23,1983 |
| Cytogenetic Analysis | lung/hamster | 500 mg/L | GMCRDC 27,95,1981 |
| Cytogenetic Analysis | fibroblast/hamster | 40 mmol/L | MUREAV 51,397,1978 |
| Cytogenetic Analysis | ovary/hamster | 1110 µmol/L | MOTOEX 1,217,1987 |
| Cytogenetic Analysis | lymphocyte/cattle | 60 µmol/L | MUREAV 290,311,1993 |
| Cytogenetic Analysis | HeLa cell/human | 10 µmol/L | TXCYAC 9,21,1978 |
| Cytogenetic Analysis | lymphocyte/human | 50 mmol/L | ARTODN 39,159,1977 |
| Cytogenetic Analysis | subcutaneous/rat | 40 mg/kg | NULSAK 23,121,1980 |
| Cytogenetic Analysis | liver/rat | 45 µmol/L | CRNGDP 8,1077,1987 |
| Cytogenetic Analysis | oral/rat | 20 mg/kg | MUREAV 251,59,1991 |
| Cytogenetic Analysis | lung/hamster | 1000 mg/L/6H (+enzymatic activation step) | FCTOD7 40,599,2002 |
| Cytogenetic Analysis | other cell types/mouse | 2 mg/L (+enzymatic activation step) | TCMUD8 23(Suppl 1),137,2003 |
| Cytogenetic Analysis | inhalation/rat | 10 mg/kg/10D | MUREAV 577S,1,2005 |
| Cytogenetic Analysis | other cell types/human | 5.4 mmol/L/48H | EMMUEG 50,46,2009 |
| DNA adduct | other cell types/rat | 175 µmol | PAACA3 24,65,1983 |
| DNA adduct | other cell types/rat | 6300 nmol | PAACA3 24,65,1983 |
| DNA adduct | lung/human | 27600 nmol/L | CNREA8 37,2309,1977 |
| DNA adduct | other cell types/human | 1300 nmol | PAACA3 24,65,1983 |
| DNA adduct | other cell types/human | 4100 nmol | PAACA3 24,65,1983 |
| DNA adduct | other cell types/mouse | 5 µmol | PAACA3 24,65,1983 |
| DNA adduct | other cell types/mouse | 72 µmol | PAACA3 24,65,1983 |
| DNA Damage | intraperitoneal/mouse | 5 mg/kg | CRNGDP 19,731,1998 |
| DNA Damage | kidney/rat | 32 mmol/L | MUREAV 368,41,1996 |
| DNA Damage | other cell types/mouse | 1 µmol/L | MUREAV 213,185,1989 |
| DNA Damage | multiple/mouse | 57400 µg/kg/6W-continuous | CBINA8 4,321,1971/1972 |
| DNA Damage | intraperitoneal/mouse | 5700 µg/kg | MUREAV 54,39,1978 |
| DNA Damage | oral/mouse | 15 mg/kg | IJCNAW 17,765,1976 |
| DNA Damage | intraperitoneal/gerbil | 100 µg/kg | CNREA8 43,1306,1983 |
| DNA Damage | kidney/mammal (species unspecified) | 1 mmol/L | JTEHD6 6,333,1980 |
| DNA Damage | lymphocyte/mammal (species unspecified) | 430 µmol/L | MUREAV 135,87,1984 |
| DNA Damage | intraperitoneal/hamster | 10 µg/kg | CNREA8 39,50,1979 |
| DNA Damage | lung/hamster | 3 mmol/L | MUREAV 187,181,1987 |
| DNA Damage | ovary/hamster | 5 mmol/L | MUREAV 77,259,1980 |
| DNA Damage | liver/hamster | 50 µmol/L | EMMUEG 15,24,1990 |
| DNA Damage | kidney/human | 32 mmol/L | MUREAV 368,41,1996 |
| DNA Damage | other cell types/rat | 1 mmol/L | CRNGDP 5,1453,1984 |
| DNA Damage | other cell types/human | 90 mmol/L | MUREAV 441,215,1999 |
| DNA Damage | unreported route/rat | 5 mg/kg | CBINA8 15,101,1976 |
| DNA Damage | intravenous/rat | 1 µg/kg | CNREA8 41,3128,1981 |
| DNA Damage | intraperitoneal/rat | 5 mg/kg | CALEDQ 40,203,1988 |
| DNA Damage | oral/rat | 22 µg/kg | CNREA8 47,3485,1987 |
| DNA Damage | parenteral/rat | 2 mg/kg | NATUAS 248,153,1974 |
| DNA Damage | fibroblast/hamster | 10 µmol/L/6H | MUREAV 726,84,2011 |
| DNA Damage | ovary/hamster | 0.1 mmol/L/4H (+enzymatic activation step) | MUREAV 741,109,2012 |
| DNA Damage | lymphocyte/human | 50 µmol/L (-enzymatic activation step) | MUREAV 743,25,2012 |
| DNA Damage | sperm/human | 50 µmol/L (-enzymatic activation step) | MUREAV 743,25,2012 |
| DNA Damage | lymphocyte/human | 5 µmol/L (+enzymatic activation step) | MUREAV 743,25,2012 |
| DNA Damage | sperm/human | 5 µmol/L (+enzymatic activation step) | MUREAV 743,25,2012 |
| DNA Damage | ovary/human | 2 mmol/L | MUREAV 575,17,2005 |
| DNA Damage | liver/human | 100 µmol/L/24H | MUREAV 657,133,2008 |
| DNA Damage | liver/rat | 1 mmol/L/20H | MUREAV 564,21,2004 |
| DNA Damage | other cell types/human | 27 mmol/L/4H | MUREAV 536,79,2003 |
| DNA Damage | intraperitoneal/mouse | 360 mg/kg/12W | MUREAV 579,81,2005 |
| DNA Damage | other cell types/human | 2000 µmol/L/24H | MUTAEX 25,555,2010 |
| DNA Damage | liver/mouse | 2 mmol/L/24H | MUTAEX 25,561,2010 |
| DNA Damage | liver/mouse | 2 mmol/L/48H | MUTAEX 25,561,2010 |
| DNA Damage | oral/rat | 60 mg/kg/3D- intermittent | MUREAV 722,7,2011 |
| DNA Damage | lung/rat | 2.5 mmol/L/20H | MUREAV 605,94,2006 |
| DNA Damage | lung/human | 2.5 mmol/L/20H | MUREAV 605,94,2006 |
| DNA Damage | liver/rat | 100 µmol/L/3H | MUREAV 629,49,2007 |
| DNA Damage | other cell types/rat | 10 mmol/L/16H | BCPCA6 68,523,2004 |
| DNA Damage | liver/human | 1 mmol/L/4H | TXAPA9 182,219,2002 |
| DNA Damage | liver/rat | 1 mmol/L/4H | TXAPA9 182,219,2002 |
| DNA Damage | oral/other insects | 0.25 µmol/tube | MUREAV 480-481,139,2001 |
| DNA Damage | liver/rat | 5 mmol/L | TOSCF2 53,71,2000 |
| DNA Damage | liver/human | 5 mmol/L | TOSCF2 53,71,2000 |
| DNA Damage | lung/hamster | 2 mg/L/3H (+enzymatic activation step) | MUREAV 536,27,2003 |
| DNA Damage | oral/mouse | 0.0135 mmol/kg | MUREAV 539,65,2003 |
| DNA inhibition | intraperitoneal/rat | 9 mg/kg | CBINA8 27,81,1979 |
| DNA inhibition | subcutaneous/rat | 12500 µg/kg | BIMDB3 20,119,1974 |
| DNA inhibition | HeLa cell/human | 100 mmol/L/1H-continuous | JEPTDQ 2(1),65,1978 |
| DNA inhibition | parenteral/mouse | 20 mg/kg | RCOCB8 21,281,1978 |
| DNA inhibition | intraperitoneal/mouse | 20 gm/kg | ARGEAR 51,605,1981 |
| DNA repair | /Escherichia coli | 50 ng/well | MUREAV 46,53,1977 |
| DNA repair | /Bacillus subtilis | 25 gm/L | EVSRBT 24,19,1981 |
| DNA repair | liver/rat | 5 mmol/L/20H | MUREAV 536,69,2003 |
| DNA repair | liver/human | 5 mmol/L/20H | MUREAV 536,69,2003 |
| DNA repair | other cell types/human | 5.4 mmol/L/48H | EMMUEG 50,46,2009 |
| Dominant Lethal Test | oral/Drosophila melanogaster | 10 mmol/L | RPZHAW 33,215,1982 |
| Dominant Lethal Test | intraperitoneal/mouse | 4400 µg/kg | MGGEAE 117,197,1972 |
| Dominant Lethal Test | subcutaneous/mouse | 45 mg/kg | ATXKA8 28,135,1971 |
| gene conversion and mitotic recombination | /Saccharomyes cerevisiae | 5 mmol/L | MUREAV 108,161,1983 |
| gene conversion and mitotic recombination | /Aspergillus nidulans | 20096 µg/plate | MUREAV 80,265,1981 |
| gene conversion and mitotic recombination | /Chlamydomonas reinhardi | 68 µmol/L | CUGED5 10,393,1986 |
| gene conversion and mitotic recombination | oral/Drosophila melanogaster | 0.076 mmol/L | FCTOD7 49,2172,2011 |
| gene conversion and mitotic recombination | oral/Drosophila melanogaster | 1 mmol/L/48H | MUTAEX 19,187,2004 |
| gene conversion and mitotic recombination | /Drosophila melanogaster | 0.01 mmol/L | MUREAV 514,193,2002 |
| gene conversion and mitotic recombination | /Saccharomyes cerevisiae | 200 mmol/L/3H (-enzymatic activation step) | EMMUEG 36,97,2000 |
| gene conversion and mitotic recombination | /Saccharomyes cerevisiae | 200 mmol/L/3H (+enzymatic activation step) | EMMUEG 36,97,2000 |
| host-mediated assay | Saccharomyes cerevisiae/rat | 3705 mg/kg | MUREAV 31,381,1975 |
| host-mediated assay | Salmonella typhimurium/rat | 600 µg/kg | ENMUDM 1,277,1979 |
| host-mediated assay | Escherichia coli/mammal (species unspecified) | 100 mg/kg | ARZNAD 24,1422,1974 |
| host-mediated assay | leukocyte/mouse | 2500 µg/kg | CNREA8 34,3073,1974 |
| host-mediated assay | Schizosaccharomyces pombe/mouse | 1 mg/kg | MUREAV 85,57,1981 |
| host-mediated assay | Salmonella typhimurium/mouse | 24200 µg/kg | MGGEAE 117,197,1972 |
| host-mediated assay | Serratia marcescens/mouse | 12 mg/kg/2H | MGGEAE 117,197,1972 |
| host-mediated assay | Saccharomyes cerevisiae/mouse | 10 µmol/kg | AGACBH 3,99,1973 |
| host-mediated assay | Escherichia coli/mouse | 15 mg/kg | MUREAV 25,187,1974 |
| host-mediated assay | other cell types/mouse | 2 mg/kg | MUREAV 207,57,1988 |
| micronucleus test | intraperitoneal/hamster | 10 mg/kg | MUREAV 43,255,1977 |
| micronucleus test | inhalation/mouse | 1030 mg/m3 | NEZAAQ 40,280,1985 |
| micronucleus test | intraperitoneal/mouse | 10 mg/kg | MUREAV 278,103,1992 |
| micronucleus test | oral/mouse | 12500 µg/kg | MUREAV 97,43,1982 |
| micronucleus test | liver/human | 5 mmol/L | MUREAV 414,37,1998 |
| micronucleus test | parenteral/rat | 30 mg/kg | ZKKOBW 84,135,1975 |
| micronucleus test | liver/rat | 5 mmol/L | TOSCF2 53,71,2000 |
| micronucleus test | liver/human | 10 mmol/L/4H | MUREAV 536,79,2003 |
| micronucleus test | intraperitoneal/rat | 5 mg/kg | MUREAV 583,133,2005 |
| micronucleus test | other cell types/human | 6.4 mmol/L/4H | MUREAV 536,79,2003 |
| micronucleus test | oral/rat | 60 mg/kg/3D- intermittent | MUREAV 722,7,2011 |
| micronucleus test | other cell types/human | 100 µmol/L/3H | MUREAV 724,7,2011 |
| micronucleus test | oral/rat | 5 mg/kg | MUTAEX 24,9,2009 |
| morphological transform | intraperitoneal/mouse | 360 mg/kg/12W | MUREAV 579,81,2005 |
| morphological transform | oral/rat | 16 mg/kg/14D- intermittent | MUREAV 575,61,2005 |
| morphological transform | intraperitoneal/rat | 60 mg/kg | ONCOBS 34,16,1977 |
| morphological transform | oral/rat | 100 µmol/kg | CBINA8 43,313,1983 |
| morphological transform | liver/rat | 100 mg/L | BJCAAI 28,215,1973 |
| morphological transform | embryo/rat | 1300 mg/L | JJIND8 67,1303,1981 |
| morphological transform | other cell types/human | 200 µg/L | CANCAR 47,1543,1981 |
| morphological transform | fibroblast/human | 1 µg/L | BANRDU 12,3,1982 |
| morphological transform | fibroblast/mouse | 500 µg/L | JJIND8 67,1303,1981 |
| morphological transform | kidney/hamster | 80 µg/L | BJCAAI 37,873,1978 |
| morphological transform | embryo/hamster | 100 mg/L | IJCNAW 19,642,1977 |
| morphological transform | oral/hamster | 200 mg/kg | EVHPAZ 45,119,1982 |
| mutation in mammalian somatic cells | intraperitoneal/hamster | 200 mg/kg | TOLED5 2,277,1978 |
| mutation in mammalian somatic cells | lung/hamster | 100 µmol/L | ENMUDM 6,454,1984 |
| mutation in mammalian somatic cells | ovary/hamster | 100 mg/L | ENMUDM 6,539,1984 |
| mutation in mammalian somatic cells | embryo/rat | 100 µg/L | JTEHD6 4,79,1978 |
| mutation in mammalian somatic cells | intraperitoneal/mouse | 4 mg/kg/4D-continuous | MUREAV 412,161,1998 |
| mutation in mammalian somatic cells | lymphocyte/mouse | 3700 mg/L | JEPTDQ 4(2-3),327,1980 |
| mutation in mammalian somatic cells | lymphocyte/human | 14 mmol/L | MUREAV 128,221,1984 |
| mutation in mammalian somatic cells | ovary/hamster | 200 mg/L/5H (-enzymatic activation step) | JAPTO* 21,449,2001 |
| mutation in mammalian somatic cells | ovary/hamster | 200 mg/L/5H (+enzymatic activation step) | JAPTO* 21,449,2001 |
| mutation in microorganisms | /Salmonella typhimurium | 135 nmol/plate/48H (+enzymatic activation step) | MUREAV 541,123,2003 |
| mutation in microorganisms | /Salmonella typhimurium | 360 mg/L/2H (+enzymatic activation step) | MUREAV 578,210,2005 |
| mutation in microorganisms | /Salmonella typhimurium | 1 mg/plate (+enzymatic activation step) | MUTAEX 16,479,2001 |
| mutation in microorganisms | /Saccharomyes cerevisiae | 1.56 mg/L/16H | MUTAEX 20,317,2005 |
| mutation in microorganisms | /Saccharomyes cerevisiae | 50 mg/L/18H (+enzymatic activation step) | MUREAV 653,63,2008 |
| mutation in microorganisms | /Salmonella typhimurium | 196 nmol/tube/45H (+enzymatic activation step) | MUREAV 653,14,2008 |
| mutation in microorganisms | /Schizosaccharomyces pombe | 1000 µg/plate (+enzymatic activation step) | FCTOD7 49,1303,2011 |
| mutation in microorganisms | /Salmonella typhimurium | 50 µmol/L/72H (+enzymatic activation step) | MUREAV 741,109,2012 |
| mutation in microorganisms | /Salmonella typhimurium | 5 µg/plate/48H (+enzymatic activation step) | FCTOD7 50,3360,2012 |
| mutation in microorganisms | /Escherichia coli | 140 nmol/plate (+enzymatic activation step) | MUREAV 135,87,1984 |
| mutation in microorganisms | /Aspergillus nidulans | 20096 µg/plate (-enzymatic activation step) | MUREAV 80,265,1981 |
| mutation in microorganisms | /Neurospora crassa | 100 nmol/L (-enzymatic activation step) | MUREAV 3,537,1966 |
| mutation in microorganisms | /Neurospora crassa | 90 mmol/L (+enzymatic activation step) | MUREAV 31,195,1975 |
| mutation in microorganisms | /Saccharomyes cerevisiae | 450 mmol/L (-enzymatic activation step) | BBRCA9 83,14,1978 |
| mutation in microorganisms | /Saccharomyes cerevisiae | 350 mmol/L (+enzymatic activation step) | MUREAV 45,309,1977 |
| mutation in microorganisms | /Other microorganisms | 1 pph/72H-continuous (-enzymatic activation step) | SOGEBZ 10,522,1974 |
| mutation in microorganisms | /Salmonella typhimurium | 50 µL/plate (+enzymatic activation step) | MUREAV 54,101,1978 |
| mutation in microorganisms | /Salmonella typhimurium | 10 mmol/L (-enzymatic activation step) | CALEDQ 47,63,1989 |
| mutation in microorganisms | mammary gland/mouse | 10 mmol/L (+enzymatic activation step) | MUREAV 30,249,1975 |
| mutation in microorganisms | lymphocyte/mouse | 100 µg/L (+enzymatic activation step) | ENMUDM 9,331,1987 |
| mutation in microorganisms | /Salmonella typhimurium | 0.2 µmol/plate/48H (-enzymatic activation step) | MUREAV 484,61,2001 |
| mutation in microorganisms | lung/hamster | 100 µmol/L (+enzymatic activation step) | CRNGDP 6,1403,1985 |
| mutation in microorganisms | ovary/hamster | 150 µmol/L (+enzymatic activation step) | MOTOEX 1,217,1987 |
| other mutation test systems | intravenous/mouse | 25 mg/kg | ARTODN 54,215,1983 |
| other mutation test systems | oral/mouse | 35 mg/kg | CBINA8 21,45,1978 |
| other mutation test systems | intraperitoneal/mouse | 40 mg/kg | CNREA8 44,5110,1984 |
| other mutation test systems | /Salmonella typhimurium | 1500 mg/L | MUREAV 192,239,1987 |
| other mutation test systems | /Escherichia coli | 40 nmol/tube | PNASA6 79,5971,1982 |
| other mutation test systems | intraperitoneal/rat | 30 mg/kg | BBACAQ 654,31,1981 |
| other mutation test systems | intraperitoneal/rat | 4 mg/kg | BBACAQ 697,336,1982 |
| sex chromosome loss and nondisjunction | parenteral/Drosophila melanogaster | 2 mmol/L | CBINA8 14,21,1976 |
| sex chromosome loss and nondisjunction | oral/Drosophila melanogaster | 2500 µmol/L | ENMUDM 2,187,1980 |
| sister chromatid exchange | intraperitoneal/rat | 10 mg/kg | MUREAV 107,131,1983 |
| sister chromatid exchange | liver/rat | 100 nmol/L | CRNGDP 8,1077,1987 |
| sister chromatid exchange | oral/rat | 10 mg/kg | MUREAV 251,59,1991 |
| sister chromatid exchange | fibroblast/human | 3 mmol/L | ENMUDM 4,203,1982 |
| sister chromatid exchange | lymphocyte/human | 29 mg/L | CNREA8 40,4775,1980 |
| sister chromatid exchange | intraperitoneal/mouse | 120 µmol/kg | TCMUD8 9,219,1989 |
| sister chromatid exchange | lung/mouse | 15 mg/kg | PSEBAA 158,269,1978 |
| sister chromatid exchange | intraperitoneal/hamster | 15 mg/kg | PSEBAA 158,269,1978 |
| sister chromatid exchange | fibroblast/hamster | 40 mmol/L | MUREAV 51,397,1978 |
| sister chromatid exchange | ovary/hamster | 500 µg/L | ENMUDM 7,1,1985 |
| sister chromatid exchange | other cell types/hamster | 40 mmol/L/30M | ARTODN 46,61,1980 |
| sister chromatid exchange | lung/hamster | 10 µmol/L | ENMUDM 6,454,1984 |
| sister chromatid exchange | oral/hamster | 50 mg/kg | MUREAV 113,33,1983 |
| sister chromatid exchange | lymphocyte/cattle | 6 µmol/L | MUREAV 290,311,1993 |
| sister chromatid exchange | lung/hamster | 0.01 µmol/L/32H | MUREAV 580,41,2005 |
| sister chromatid exchange | ovary/hamster | 0.2 gm/L/4H (+enzymatic activation step) | JAPTO* 22,45,2001 |
| sister chromatid exchange | ovary/hamster | 300 mg/L/2H (+enzymatic activation step) | JAPTO* 21,449,2001 |
| specific locus test | ovary/hamster | 0.2 gm/L/24H (+enzymatic activation step) | JAPTO* 22,45,2001 |
| specific locus test | other cell types/mouse | 10 mg/L (+enzymatic activation step) | MUREAV 577S,1,2005 |
| specific locus test | other cell types/human | 46.31 mg/L/3H (+enzymatic activation step) | MUTAEX 24,35,2009 |
| specific locus test | other cell types/human | 43 mg/L/16H (+enzymatic activation step) | MUREAV 724,76,2011 |
| specific locus test | multiple/Drosophila melanogaster | 74.1 mg/L/48H | MUTAEX 19,187,2004 |
| specific locus test | ovary/hamster | 700 mg/L | PMRSDJ 1,594,1981 |
| specific locus test | intraperitoneal/mouse | 7500 µg/kg | ARTODN 38,87,1977 |
| specific locus test | oral/Drosophila melanogaster | 100 µmol/L | ENMUDM 5,455,1983 |
| specific locus test | parenteral/Drosophila melanogaster | 1 mmol/L | CNREA8 35,3780,1975 |
| sperm morphology | intraperitoneal/mouse | 2 mg/kg | TXCYAC 12,183,1979 |
| Unscheduled DNA Synthesis | liver/monkey | 5 mmol/L | MUREAV 206,91,1988 |
| Unscheduled DNA Synthesis | liver/hamster | 100 µmol/L | ENMUDM 6,1,1984 |
| Unscheduled DNA Synthesis | lung/hamster | 10 µmol/L | ENMUDM 6,454,1984 |
| Unscheduled DNA Synthesis | subcutaneous/mouse | 150 mg/kg | PSEBAA 145,1339,1974 |
| Unscheduled DNA Synthesis | oral/mouse | 1200 µg/kg | BBRCA9 58,242,1974 |
| Unscheduled DNA Synthesis | liver/mouse | 10 µmol/L | TOPADD 12,119,1984 |
| Unscheduled DNA Synthesis | intraperitoneal/mouse | 3 mg/kg | TXAPA9 53,357,1980 |
| Unscheduled DNA Synthesis | other cell types/human | 30 mg/L | MUREAV 271,201,1992 |
| Unscheduled DNA Synthesis | liver/other fish | 100 µmol/L | NCIMAV 65,163,1984 |
| Unscheduled DNA Synthesis | other cell types/human | 1300 µmol/L | MUREAV 235,81,1990 |
| Unscheduled DNA Synthesis | fibroblast/human | 1 mmol/L/1H | IJCNAW 16,284,1975 |
| Unscheduled DNA Synthesis | HeLa cell/human | 100 µmol/L | CNREA8 38,2621,1978 |
| Unscheduled DNA Synthesis | other cell types/human | 1 mmol/L | JJIND8 69,557,1982 |
| Unscheduled DNA Synthesis | liver/human | 1 mmol/L | BANRDU 13,101,1982 |
| Unscheduled DNA Synthesis | subcutaneous/rat | 1560 µg/kg | BIMDB3 20,119,1974 |
| Unscheduled DNA Synthesis | liver/rat | 30 mg/L | MUREAV 124,299,1983 |
| Unscheduled DNA Synthesis | oral/rat | 625 µg/kg | MUREAV 344,109,1995 |
| Unscheduled DNA Synthesis | intraperitoneal/rat | 1 mg/kg | CRNGDP 3,1071,1982 |
| Unscheduled DNA Synthesis | inhalation/rat | 500 ppm/4H | PAACA3 25,106,1984 |
| Unscheduled DNA Synthesis | other cell types/rat | 5 mmol/L | CRNGDP 5,1453,1984 |
| Unscheduled DNA Synthesis | other cell types/rat | 1 mmol/L | CRNGDP 5,773,1984 |
| Unscheduled DNA Synthesis | other cell types/rat | 5 mmol/L | PAACA3 25,106,1984 |
| Unscheduled DNA Synthesis | liver/human | 10 mmol/L/44H | MUREAV 559,211,2004 |
| Unscheduled DNA Synthesis | intravenous/rat | 10 mg/kg | TCMUD8 23(Suppl 1),137,2003 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| intraperitoneal/rat | 5 mg/kg (12D pregnant) | Reproductive: Effects on embryo or fetus: Fetal death | CNREA8 33,2231,1973 |
| intraperitoneal/mouse | 10 mg/kg (18D pregnant) | Reproductive: Effects on newborn: Biochemical and metabolic | TXCYAC 24,251,1982 |
| intraplacental/rat | 500 µg/kg (13D pregnant) | Reproductive: Effects on embryo or fetus: Fetal death | BEXBAN 78,1308,1974 |
| intravenous/rat | 20 mg/kg (10D pregnant) | Reproductive: Effects on embryo or fetus: Fetal death | ZEKBAI 71,32,1968 |
| oral/mouse | 1940 µg/kg (75D prior to copulation/1-22D pregnant) | Reproductive: Effects on newborn: Stillbirth Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) | RCOCB8 19,311,1978 |
| oral/rat | 20 mg/kg (20D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | FCTOD7 21,453,1983 |
| oral/rat | 30 mg/kg (10D pregnant) | Reproductive: Effects on embryo or fetus: Fetal death | ZEKBAI 71,32,1968 |
| oral/rat | 35 mg/kg (8-14D pregnant) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on embryo or fetus: Fetal death Reproductive: Other developmental abnormalities | VOONAW 13(5),87,1967 |
| oral/rat | 30 mg/kg (10D pregnant) | Reproductive: Effects on fertility: Abortion | VOONAW 13(5),87,1967 |
| oral/rat | 35 mg/kg (1-7D pregnant) | Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) | VOONAW 13(5),87,1967 |
| unreported route/rat | 7 mg/kg (1-7D pregnant) | Reproductive: Other effects to embryo or fetus | IARCCD 4,1,1973 |
Tumorigenic Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/mouse | lowest published toxic concentration: 200 µg/m3/45W- continuous | Tumorigenic: Neoplastic by RTECS criteria Lung, Thorax, or Respiration: Tumors Liver: Tumors | VOONAW 21(6),107,1975 |
| inhalation/rat | lowest published toxic concentration: 200 µg/m3/45W- continuous | Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors Kidney, Ureter, and Bladder: Kidney tumors | VOONAW 21(6),107,1975 |
| intramuscular/rat | lowest published toxic dose: 18 mg/kg | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, and Bladder: Kidney tumors | INURAQ 4,39,1966 |
| intraperitoneal/hamster | lowest published toxic dose: 20 mg/kg | Tumorigenic: Neoplastic by RTECS criteria Liver: Tumors | CRNGDP 1,91,1980 |
| intraperitoneal/mouse | toxic dose: 7 mg/kg | Tumorigenic: Neoplastic by RTECS criteria Lung, Thorax, or Respiration: Tumors Liver: Tumors | CBINA8 1,395,1969/1970 |
| intraperitoneal/mouse | lowest published toxic dose: 1 mg/kg | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Liver: Tumors | MUREAV 477,41,2001 |
| intraperitoneal/mouse | lowest published toxic dose: 2.400 mg/kg/7D- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors | CALEDQ 143,81,1999 |
| intraperitoneal/mouse | lowest published toxic dose: 10 mg/kg | Tumorigenic: Carcinogenic by RTECS criteria Lung, Thorax, or Respiration: Tumors Tumorigenic: Increased incidence of tumors in susceptible strains | TXAPA9 179,21,2002 |
| intraperitoneal/mouse | lowest published toxic dose: 7 mg/kg | Tumorigenic: Carcinogenic by RTECS criteria Lung, Thorax, or Respiration: Tumors | IJCNAW 28,199,1981 |
| intraperitoneal/rat | lowest published toxic dose: 30 mg/kg | Tumorigenic: Carcinogenic by RTECS criteria Kidney, Ureter, and Bladder: Kidney tumors | CNREA8 30,2796,1970 |
| intraperitoneal/rat | toxic dose: 40 mg/kg | Tumorigenic: Carcinogenic by RTECS criteria Lung, Thorax, or Respiration: Consolidation Kidney, Ureter, and Bladder: Kidney tumors | BJEPA5 51,587,1970 |
| intraperitoneal/rat | toxic dose: 30 mg/kg | Tumorigenic: Carcinogenic by RTECS criteria Lung, Thorax, or Respiration: Tumors Kidney, Ureter, and Bladder: Bladder tumors | CRNGDP 5,1003,1984 |
| intraperitoneal/rat | toxic dose: 20 mg/kg | Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors Kidney, Ureter, and Bladder: Kidney tumors | JSONAU 8,539,1976 |
| intrarenal/rat | lowest published toxic dose: 20 mg/kg | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, and Bladder: Kidney tumors | JJIND8 71,787,1983 |
| intratracheal/hamster | lowest published toxic dose: 12 mg/kg/8W- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Tumors | CRNGDP 9,947,1988 |
| intratracheal/hamster | lowest published toxic dose: 12 mg/kg/15W- intermittent | Tumorigenic: Neoplastic by RTECS criteria Lung, Thorax, or Respiration: Tumors | FCTOD7 26,847,1988 |
| intravenous/rat | lowest published toxic dose: 18 mg/kg | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, and Bladder: Kidney tumors | INURAQ 4,39,1966 |
| multiple/rat | lowest published toxic dose: 420 mg/kg/2W- continuous | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, and Bladder: Kidney tumors | APJAAG 23,87,1973 |
| oral/frog | lowest published toxic dose: 3076 mg/kg/29W- continuous | Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors | BEXBAN 92,1084,1981 |
| oral/hamster | lowest published toxic dose: 13 mg/kg | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Liver: Tumors | BJCAAI 46,985,1982 |
| oral/mammal (species unspecified) | lowest published toxic dose: 49 mg/kg/71W- continuous | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Liver: Tumors | IARCCD 14,443,1976 |
| oral/mouse | toxic dose: 370 mg/kg/56W- continuous | Tumorigenic: Carcinogenic by RTECS criteria Lung, Thorax, or Respiration: Tumors Liver: Tumors | JNCIAM 41,1213,1968 |
| oral/mouse | lowest published toxic dose: 140 µg/kg (4W pre-3W after birth) | Tumorigenic: Neoplastic by RTECS criteria Reproductive: Tumorigenic effects: Transplacental tumorigenesis Lung, Thorax, or Respiration: Tumors | JJIND8 62,1553,1979 |
| oral/mouse | lowest published toxic dose: 80 mg/kg/8W- continuous | Tumorigenic: Carcinogenic by RTECS criteria Lung, Thorax, or Respiration: Tumors | IJCNAW 28,199,1981 |
| oral/mouse | toxic dose: 11 mg/kg/16W- continuous | Tumorigenic: Neoplastic by RTECS criteria Lung, Thorax, or Respiration: Tumors | PAACA3 25,98,1984 |
| oral/rabbit | lowest published toxic dose: 325 mg/kg/37W- continuous | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Tumors Liver: Tumors | BJCAAI 23,125,1969 |
| oral/rat | lowest published toxic dose: 30 mg/kg (21D pregnant) | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Reproductive: Tumorigenic effects: Transplacental tumorigenesis Kidney, Ureter, and Bladder: Kidney tumors | BEXBAN 78,1308,1974 |
| oral/rat | lowest published toxic dose: 23 mg/kg/2Y- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Gastrointestinal: Tumors Liver: Tumors | CNREA8 41,4997,1981 |
| oral/rat | toxic dose: 42 mg/kg/30W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Gastrointestinal: Tumors Liver: Tumors | CNREA8 41,4997,1981 |
| oral/rat | toxic dose: 336 mg/kg/2W- continuous | Tumorigenic: Neoplastic by RTECS criteria Kidney, Ureter, and Bladder: Kidney tumors | TOLED5 18(Suppl 1),115,1983 |
| oral/rat | toxic dose: 114 mg/kg/81W- intermittent | Tumorigenic: Neoplastic by RTECS criteria Liver: Tumors | GISAAA 48(3),19,1983 |
| skin/mouse | lowest published toxic dose: 800 mg/kg/20W- intermittent | Tumorigenic: Neoplastic by RTECS criteria Lung, Thorax, or Respiration: Bronchogenic carcinoma Tumorigenic: Increased incidence of tumors in susceptible strains | EJCAAH 16,695,1980 |
| subcutaneous/hamster | toxic dose: 74200 µg/kg/53W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors | CALEDQ 31,181,1986 |
| subcutaneous/hamster | lowest published toxic dose: 62 mg/kg/44W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors | JNCIAM 51,1295,1973 |
| subcutaneous/hamster | lowest published toxic dose: 12 mg/kg (14D pregnant) | Tumorigenic: Neoplastic by RTECS criteria Reproductive: Tumorigenic effects: Transplacental tumorigenesis Endocrine: Tumors | ZKKOBW 90,79,1977 |
| subcutaneous/mouse | lowest published toxic dose: 38 mg/kg (17-19D pregnant) | Tumorigenic: Carcinogenic by RTECS criteria Reproductive: Tumorigenic effects: Transplacental tumorigenesis Lung, Thorax, or Respiration: Tumors | VOONAW 17(8),75,1971 |
| subcutaneous/mouse | lowest published toxic dose: 70 mg/kg/1W- continuous | Tumorigenic: Neoplastic by RTECS criteria Lung, Thorax, or Respiration: Tumors Kidney, Ureter, and Bladder: Kidney tumors | BJCAAI 20,871,1966 |
| subcutaneous/rat | lowest published toxic dose: 24466 µg/kg/20W- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Liver: Tumors | CNREA8 46,498,1986 |
| unreported route/rat | lowest published toxic dose: 7 mg/kg (15-21D pregnant) | Tumorigenic: Neoplastic by RTECS criteria Reproductive: Tumorigenic effects: Transplacental tumorigenesis Kidney, Ureter, and Bladder: Kidney tumors | IARCCD 4,1,1973 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/Dog | Lowest published lethal concentration: 16 ppm/4H | Behavioral: Food intake (animal) Gastrointestinal: Nausea or vomiting Nutritional and Gross Metabolic: Body temperature increase | AMIHAB 12,617,1955 |
| inhalation/mouse | lethal concentration (50 percent kill): 57 ppm/4H | Eye: Other eye effects Behavioral: Somnolence (general depressed activity) Blood: Hemorrhage | AMIHAB 12,617,1955 |
| inhalation/rat | lethal concentration (50 percent kill): 78 ppm/4H | Eye: Other eye effects Behavioral: Somnolence (general depressed activity) Blood: Hemorrhage | AMIHAB 12,617,1955 |
| inhalation/rat | lethal concentration (50 percent kill): 78 ppm/4H | ENTOX* -,255,2005 | |
| intraperitoneal/guinea pig | lethal dose (50 percent kill): 13700 µg/kg | CRNGDP 5,533,1984 | |
| intraperitoneal/hamster | lowest published lethal dose: 30 mg/kg | CRNGDP 1,91,1980 | |
| intraperitoneal/mouse | lethal dose (50 percent kill): 19 mg/kg | EXPEAM 32,495,1976 | |
| intraperitoneal/mouse | lowest published toxic dose: 5 mg/kg | Liver: Other changes | MUREAV 577S,1,2005 |
| intraperitoneal/rat | lowest published toxic dose: 20 mg/kg | Liver: Hepatitis (hepatocellular necrosis), zonal Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases Biochemical: Metabolism (intermediary): Lipids including transport | FCTOD7 46,1279,2008 |
| intraperitoneal/rat | lowest published toxic dose: 10 µg/kg | Liver: Other changes Biochemical: Metabolism (intermediary): Other proteins | ETPAEK 61,287,2009 |
| intraperitoneal/rat | lowest published toxic dose: 50 mg/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Food intake (animal) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) | FATOAO 46,111,1983 |
| intraperitoneal/rat | lethal dose (50 percent kill): 26500 µg/kg | Behavioral: Somnolence (general depressed activity) Gastrointestinal: Other changes Skin and Appendages: Other: Hair | BJIMAG 11,167,1954 |
| intravenous/rat | lowest published lethal dose: 40 mg/kg | Behavioral: Somnolence (general depressed activity) Gastrointestinal: Other changes Skin and Appendages: Other: Hair | BJIMAG 11,167,1954 |
| oral/Dog | lowest published lethal dose: 20 mg/kg | Behavioral: Muscle weakness Gastrointestinal: Nausea or vomiting Blood: Hemorrhage | BJIMAG 11,167,1954 |
| oral/guinea pig | lowest published lethal dose: 25 mg/kg | Liver: Liver function tests impaired Kidney, Ureter, and Bladder: Changes primarily in glomeruli Blood: Thrombocytopenia | STGNBT -,183,1999 |
| oral/hamster | lethal dose (50 percent kill): 28 mg/kg | Gastrointestinal: Ulceration or bleeding from stomach Liver: Hepatitis (hepatocellular necrosis), diffuse Liver: Fatty liver degeneration | JNCIAM 33,341,1964 |
| oral/rabbit | lowest published lethal dose: 10 mg/kg | Liver: Liver function tests impaired Kidney, Ureter, and Bladder: Changes primarily in glomeruli Blood: Thrombocytopenia | STGNBT -,183,1999 |
| oral/rat | lethal dose (50 percent kill): 37 mg/kg | GISAAA 50(8),81,1985 | |
| oral/rat | lowest published toxic dose: 50 mg/kg | Liver: Other changes Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | BCPCA6 67,2141,2004 |
| oral/rat | lethal dose (50 percent kill): 26 mg/kg | Lung, Thorax, or Respiration: Other changes Liver: Multiple effects Blood: Hemorrhage | ENTOX* -,255,2005 |
| oral/woman | lowest published lethal dose: 20 mg/kg/2.5Y | Gastrointestinal: Ulceration or bleeding from small intestine Gastrointestinal: Nausea or vomiting Nutritional and Gross Metabolic: Body temperature increase | ONCOBS 37,273,1980 |
| subcutaneous/hamster | lethal dose (50 percent kill): 17700 µg/kg | Lung, Thorax, or Respiration: Other changes Liver: Other changes Blood: Other changes | BJCAAI 33,411,1976 |
| subcutaneous/mammal (species unspecified) | lethal dose (50 percent kill): 10 mg/kg | Liver: Other changes Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | AVSCA7 22,501,1981 |
| subcutaneous/rat | lethal dose (50 percent kill): 15 mg/kg | Liver: Liver function tests impaired Kidney, Ureter, and Bladder: Changes primarily in glomeruli Blood: Thrombocytopenia | STGNBT -,183,1999 |
| unreported route/guinea pig | lowest published lethal dose: 25 mg/kg | Blood: Hemorrhage | BJIMAG 11,167,1954 |
| unreported route/mouse | lowest published lethal dose: 20 mg/kg | Liver: Other changes | BJIMAG 11,167,1954 |
| unreported route/rabbit | lowest published lethal dose: 10 mg/kg | Liver: Other changes | BJIMAG 11,167,1954 |
| unreported route/rat | lowest published toxic dose: 30 mg/kg | Liver: Multiple effects | FATOAO 48,103,1985 |
| unreported route/rat | lethal dose (50 percent kill): 36 mg/kg | GISAAA 45(8),11,1980 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| intraperitoneal/mouse | lowest published toxic dose: 360 mg/kg/12W- continuous | Liver: Tumors Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases | MUREAV 579,81,2005 |
| intraperitoneal/mouse | lowest published toxic dose: 360 mg/kg/12W- continuous | Liver: Other changes Biochemical: Metabolism (intermediary): Lipids including transport Biochemical: Metabolism (intermediary): Other | MUREAV 579,81,2005 |
| intraperitoneal/mouse | lowest published toxic dose: 360 mg/kg/12W- continuous | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | MUREAV 579,81,2005 |
| intraperitoneal/mouse | lowest published toxic dose: 60 mg/kg/24D- intermittent | Liver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring) Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | BPBLEO 31,309,2008 |
| intraperitoneal/rat | lowest published toxic dose: 30 mg/kg/3W- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | JTPAE7 17,205,2004 |
| intraperitoneal/rat | lowest published toxic dose: 120 mg/kg/4W- intermittent | Liver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring) Liver: Jaundice (or hyperbilirubinemia) hepatocellular Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects | CHMED* 3,1,2008 |
| intraperitoneal/rat | lowest published toxic dose: 120 µL/kg/4W- continuous | Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | BPBLEO 32,1364,2009 |
| intraperitoneal/rat | lowest published toxic dose: 0.12 mg/kg/4W- intermittent | Liver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) | BJPCBM 156,1019,2009 |
| intraperitoneal/rat | lowest published toxic dose: 120 mg/kg/4W- intermittent | Liver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring) Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | FCTOD7 48,3137,2010 |
| intraperitoneal/rat | lowest published toxic dose: 120 mg/kg/4W- intermittent | Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | FCTOD7 49,93,2011 |
| intraperitoneal/rat | lowest published toxic dose: 120 mg/kg/4W- intermittent | Liver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring) Endocrine: Changes in spleen weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | JOETD7 134,953,2011 |
| intraperitoneal/rat | lowest published toxic dose: 160 mg/kg/4W- intermittent | Liver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring) | TOXID9 72,345,2003 |
| intraperitoneal/rat | lowest published toxic dose: 120 mg/kg/4W- intermittent | Liver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring) Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | CEXPB9 28,522,2001 |
| intraperitoneal/rat | lowest published toxic dose: 90 µL/kg/3W- intermittent | Liver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring) Liver: Changes in liver weight Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) | CBINA8 147,9,2004 |
| intraperitoneal/rat | lowest published toxic dose: 90 µL/kg/3W- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | CBINA8 147,9,2004 |
| intraperitoneal/rat | lowest published toxic dose: 120 µL/kg/4W- intermittent | Liver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring) Liver: Liver function tests impaired Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) | TOXID9 66,365,2002 |
| intraperitoneal/rat | lowest published toxic dose: 150 µL/kg/5W- intermittent | Liver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring) | TOXID9 60,345,2001 |
| intraperitoneal/rat | : 120 mg/kg/4W- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases Nutritional and Gross Metabolic: Weight loss or decreased weight gain Liver: Changes in liver weight | BPBLEO 27,72,2004 |
| oral/mouse | lowest published toxic dose: 90 µL/kg/3W- intermittent | Liver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring) Liver: Other changes Biochemical: Metabolism (intermediary): Other | TXAPA9 240,377,2009 |
| oral/mouse | lowest published toxic dose: 23800 µg/kg/17W- continuous | Immunological Including Allergic: Decrease in cellular immune response Immunological Including Allergic: Decrease in humoral immune response Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | JTEHD6 37,351,1992 |
| oral/rat | lowest published toxic dose: 156 mg/kg/7D- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases | TXAPA9 16,626,1970 |
| oral/rat | lowest published toxic dose: 412 mg/kg/16W- continuous | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | BJIMAG 11,167,1954 |
| oral/rat | lowest published toxic dose: 0.8 mg/kg/2D- intermittent | Liver: Other changes Biochemical: Metabolism (intermediary): Other proteins | TXAPA9 243,300,2010 |
| oral/rat | lowest published toxic dose: 5.6 mg/kg/14D- intermittent | Liver: Other changes Biochemical: Metabolism (intermediary): Other proteins | TXAPA9 243,300,2010 |
| oral/rat | lowest published toxic dose: 36 mg/kg/90D- intermittent | Liver: Other changes Biochemical: Metabolism (intermediary): Other proteins | TXAPA9 243,300,2010 |
| oral/rat | lowest published toxic dose: 30 mg/kg/15D- intermittent | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic: Weight loss or decreased weight gain | MUREAV 702,40,2010 |
| oral/rat | lowest published toxic dose: 60 mg/kg/15D- intermittent | Blood: Changes in cell count (unspecified) Blood: Changes in platelet count | MUREAV 702,40,2010 |
| oral/rat | lowest published toxic dose: 28 mg/kg/7D- intermittent | Liver: Hepatitis (hepatocellular necrosis), zonal Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | TOSCF2 77,19,2004 |
| oral/rat | lowest published toxic dose: 56 mg/kg/14D- intermittent | Liver: Hepatitis (hepatocellular necrosis), zonal Biochemical: Metabolism (intermediary): Other proteins Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | TOSCF2 77,19,2004 |
| subcutaneous/rat | lowest published toxic dose: 63 mg/kg/3W- intermittent | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Metabolism (intermediary): Lipids including transport | GISAAA 50(8),81,1985 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Control as low as possible (skin) | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Confirmed animal carcinogen | DTLVS* TLV/BEI,2013 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Animal Sufficient Evidence | IMEMDT 17,125,1978 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Human No Adequate Data | IMEMDT 17,125,1978 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Group 2A | IMSUDL 7,56,1987 |
| TOXICOLOGY REVIEW | RREVAH 64,77,1976 | |
| TOXICOLOGY REVIEW | GMCRDC 17,107,1975 | |
| TOXICOLOGY REVIEW | TXAPA9 41,157,1977 | |
| TOXICOLOGY REVIEW | 85CVA2 5,257,1970 | |
| TOXICOLOGY REVIEW | ATXKA8 28,135,1971 | |
| TOXICOLOGY REVIEW | APLMAS 107,54,1983 | |
| TOXICOLOGY REVIEW | BLFSBY 24,129,1983 | |
| TOXICOLOGY REVIEW | MUTAEX 14,141,1999 | |
| TOXICOLOGY REVIEW | ONCOBS 37,259,1980 | |
| TOXICOLOGY REVIEW | MUREAV 588,88,2005 | |
| TOXICOLOGY REVIEW | EMMUEG 44,44,2004 | |
| TOXICOLOGY REVIEW | MUTAEX 19,251,2004 | |
| TOXICOLOGY REVIEW | DIMON* 39,678,1993 | |
| TOXICOLOGY REVIEW | MUREAV 628,31,2007 | |
| TOXICOLOGY REVIEW | FCTOD7 44,1699,2006 | |
| TOXICOLOGY REVIEW | MUREAV 627,10,2007 | |
| TOXICOLOGY REVIEW | MUREAV 627,59,2007 | |
| TOXICOLOGY REVIEW | MUREAV 635,90,2007 | |
| TOXICOLOGY REVIEW | ENTOX* -,249,2005 | |
| TOXICOLOGY REVIEW | ENTOX* -,255,2005 | |
| TOXICOLOGY REVIEW | MUREAV 584,1,2005 | |
| TOXICOLOGY REVIEW | MUREAV 566,183,2004 | |
| TOXICOLOGY REVIEW | MUREAV 636,178,2007 | |
| TOXICOLOGY REVIEW | MUREAV 635,52,2007 | |
| TOXICOLOGY REVIEW | MUREAV 658,124,2008 | |
| TOXICOLOGY REVIEW | MUTAEX 19,169,2004 | |
| TOXICOLOGY REVIEW | MUREAV 659,202,2008 | |
| TOXICOLOGY REVIEW | JTPAE7 19,1,2006 | |
| TOXICOLOGY REVIEW | MUREAV 657,84,2008 | |
| TOXICOLOGY REVIEW | MUREAV 608,136,2006 | |
| TOXICOLOGY REVIEW | TXAPA9 231,197,2008 | |
| TOXICOLOGY REVIEW | TOLED5 180,110,2008 | |
| TOXICOLOGY REVIEW | MUREAV 636,144,2007 | |
| TOXICOLOGY REVIEW | MUREAV 681,68,2009 | |
| TOXICOLOGY REVIEW | MUTAEX 17,495,2002 | |
| TOXICOLOGY REVIEW | MUREAV 590,1,2005 | |
| TOXICOLOGY REVIEW | MUREAV 678,113,2009 | |
| TOXICOLOGY REVIEW | MUTAEX 23,271,2008 | |
| TOXICOLOGY REVIEW | MUREAV 705,184,2010 | |
| TOXICOLOGY REVIEW | MUTAEX 26,231,2011 | |
| TOXICOLOGY REVIEW | MUREAV 678,76,2009 | |
| TOXICOLOGY REVIEW | MUTAEX 26,223,2011 | |
| TOXICOLOGY REVIEW | MUREAV 723,101,2011 | |
| TOXICOLOGY REVIEW | MUREAV 653,99,2008 | |
| TOXICOLOGY REVIEW | EMMUEG 50,68,2009 | |
| TOXICOLOGY REVIEW | MUREAV 723,108,2011 | |
| TOXICOLOGY REVIEW | EMMUEG 50,68,2009 | |
| TOXICOLOGY REVIEW | MUTAEX 25,3,2010 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Mine Safety and Health Administration (MSHA) STANDARD | skin-SUSPECTED CARCINOGEN | DTLWS* 3,25,1973 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-AUSTRALIA | Carcinogen, JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | TRK-TMW 0.001 mg/m3;KZW 0.004 mg/m3, 2007 | |
| Occupational Exposure Limit-AUSTRIA | TRK 0.0025 mg/m3 (production), JAN 2006 | |
| Occupational Exposure Limit-BELGIUM | Skin, MAR2002 | |
| Occupational Exposure Limit-NEW ZEALAND | skin, JAN2002 | |
| Occupational Exposure Limit-SWEDEN | Group B Carcinogen, JUN2005 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 0.001 mg/m3, carc 2, skin, JAN2011 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 0.001 mg/m3, 2003 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | see Code of Federal Regulations (CFR) 29,1926.1116 | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | see Appendix A3 (skin) | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | see Code of Federal Regulations (CFR) 29,1910.1016 | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | see Code of Federal Regulations (CFR) 29,1915.1016 | CFRGBR 29,1915.1000,1993 |
| Occupational Safety and Health Administration (OSHA)-cancer suspect agent | CFRGBR 29,1910.1016,1987 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO N-NITROSODIMETHYLAMINE-air | Carcinogen use 29 Code of Federal Regulations (CFR) 1910.1016 | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code 51110; Number of Industries 1; Total Number of Facilities 75; Number of Occupations 1; Total Number of Employees Exposed 747; Total Number of Female Employees Exposed 299 |
Status in Federal Agencies
- Page last reviewed:March 7, 2014
- Page last updated:February 6, 2017
- Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division