Registry of Toxic Effects of Chemical Substances (RTECS)
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1,4:5,8-Dimethanonaphthalene, 1,2,3,4,10,10-hexachloro-6,7-epoxy-1,4,4a,5,6,7,8,8a-octahydro,endo,exo-
RTECS #
IO1750000CAS #
60-57-1; 3039-00-7Updated
December 2013Molecular Weight
380.90Molecular Formula
C12H8Cl6OSynonyms
Aldrin epoxideAlvit 55
Compound 497
Dieldrex
Dieldrin
Dieldrin (ACGIH:OSHA)
Dieldrine (French)
Dielmoth
Dorytox
ENT 16,225
exo-Dieldrin
HEOD
Hexachloroepoxyoctahydro-endo,exo-dimethanonaphthalene
Illoxol
Insecticide No. 497
Insectlack
Kombi-Albertan
Latka 497 (Czech)
Moth Snub D
NCI-C00124
Octalox
Panoram D-31
RCRA waste number P037
Red Shield
SD 3417
Termitox
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| Cytogenetic Analysis | intraperitoneal/mouse | 1200 µg/kg | SOGEBZ 2,80,1966 |
| Cytogenetic Analysis | lymphocyte/duck | 100 ppm | 34LXAP -,555,1976 |
| DNA Damage | fibroblast/mouse | 25 µmol/L/24H | MOCAT* 18,127,2003 |
| DNA Damage | mammary gland/human | 2.8 mg/L/24H (-enzymatic activation step) | MUREAV 588,47,2005 |
| DNA inhibition | lymphocyte/human | 100 mg/L | ARTODN 45,101,1980 |
| DNA inhibition | HeLa cell/human | 400 µmol/L | MUREAV 92,427,1982 |
| DNA inhibition | other cell types/rat | 10 mg/L | ARTODN 45,101,1980 |
| DNA inhibition | oral/mouse | 50 mg/kg | MUREAV 46,305,1977 |
| morphological transform | oral/rat | 15 mg/kg | CNREA8 40,1157,1980 |
| morphological transform | fibroblast/mouse | 0.01 mg/L/21D (-enzymatic activation step) | EMMUEG 35,300,2000 |
| mutation in mammalian somatic cells | lung/hamster | 10 µmol/L | CBINA8 19,369,1977 |
| mutation in microorganisms | /Salmonella typhimurium | 1 mg/L (+/-enzymatic activation step) | JOHEA8 68,184,1977 |
| other mutation test systems | other cell types/mouse | 1 ppm/4H | EESADV 3,10,1979 |
| other mutation test systems | fibroblast/mammal (species unspecified) | 50 mg/L | AECTCV 15,581,1986 |
| other mutation test systems | oral/mouse | 20 mg/kg | MUREAV 343,157,1995 |
| sister chromatid exchange | ovary/hamster | 40 mg/L | EMMUEG 10(Suppl 10),1,1987 |
| specific locus test | lymphocyte/mouse | 10 mg/L | EMMUEG 17,196,1991 |
| Unscheduled DNA Synthesis | fibroblast/human | 1 µmol/L | MUREAV 42,161,1977 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/rat | 14 µg/kg (multigenerations) | Reproductive: Effects on newborn: Behavioral | PCBPBS 13,20,1980 |
| oral/mouse | 30600 µg/kg (6-14D pregnant) | Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Specific developmental abnormalities: Eye, ear | THERAP 25,907,1970 |
| oral/mouse | 15 mg/kg (9D pregnant) | Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) | TJADAB 9,11,1974 |
| oral/mouse | 2250 µg/kg (6-14D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | TJADAB 16,57,1977 |
| oral/mouse | 12500 µg/kg (1D male) | Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) | FCTXAV 13,317,1975 |
| oral/mouse | 4500 µg/kg (6-14D pregnant) | Reproductive: Specific developmental abnormalities: Musculoskeletal system | TJADAB 16,57,1977 |
| oral/mouse | 6250 µg/kg (5D male) | Reproductive: Other effects on male | ENVRAL 9,26,1975 |
| oral/Dog | 219 mg/kg (44W prior to copulation/1-8W pregnant) | Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) | JAVMA4 123,28,1953 |
| oral/hamster | 30 mg/kg (8D pregnant) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Effects on embryo or fetus: Fetal death | TJADAB 9,11,1974 |
| oral/hamster | 30 mg/kg (8D pregnant) | Reproductive: Specific developmental abnormalities: Eye, ear Reproductive: Specific developmental abnormalities: Body wall Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) | TJADAB 9,11,1974 |
| oral/rat | 21 mg/kg (14-20D pregnant) | Reproductive: Specific developmental abnormalities: Endocrine system Reproductive: Effects on newborn: Delayed effects | ENVRAL 18,437,1979 |
Tumorigenic Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/mouse | lowest published toxic dose: 546 mg/kg/65W- continuous | Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors | ATSUDG 2,197,1979 |
| oral/mouse | toxic dose: 11 gm/kg/3Y- continuous | Tumorigenic: Neoplastic by RTECS criteria Lung, Thorax, or Respiration: Tumors Liver: Tumors | FCTXAV 11,415,1973 |
| oral/mouse | toxic dose: 610 mg/kg/73W- continuous | Tumorigenic: Neoplastic by RTECS criteria Lung, Thorax, or Respiration: Tumors Liver: Tumors | FCTXAV 11,433,1973 |
| oral/mouse | toxic dose: 714 mg/kg/85W- continuous | Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors | LAINAW 44,392,1981 |
| oral/mouse | toxic dose: 8 mg/kg/2Y- continuous | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Liver: Tumors | CRNGDP 3,941,1982 |
| oral/mouse | toxic dose: 4550 mg/kg/65W- continuous | Tumorigenic: Carcinogenic by RTECS criteria Lung, Thorax, or Respiration: Tumors Liver: Tumors | CNREA8 41,3615,1981 |
| oral/rat | lowest published toxic dose: 200 mg/kg/2Y- continuous | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Tumors Skin and Appendages: Tumors | FCTXAV 2,551,1964 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| In Vitro/Human, melanoma | Inhibitor Concentration Low: 60 µmol/L/15M | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphokinase | NETOX* 32,567,2011 |
| In Vitro/Human, melanoma | Inhibitor Concentration Low: 60 µmol/L/1H | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphokinase In Vitro Toxicity Studies: Apoptosis in vitro | NETOX* 32,567,2011 |
| inhalation/cat | lethal concentration (50 percent kill): 80 mg/m3/4H | Behavioral: Somnolence (general depressed activity) Behavioral: Convulsions or effect on seizure threshold Behavioral: Excitement | GTPZAB 8(4),30,1964 |
| inhalation/rat | lethal concentration (50 percent kill): 13 mg/m3/4H | 85GMAT -,73,1982 | |
| intracerebral/mouse | lethal dose (50 percent kill): 3 mg/kg | Behavioral: Convulsions or effect on seizure threshold | TOLED5 60,289,1992 |
| intraperitoneal/mouse | lowest published lethal dose: 26 mg/kg | TXAPA9 23,288,1972 | |
| intraperitoneal/rat | lethal dose (50 percent kill): 35 mg/kg | CBPCEE 85,437,1986 | |
| intraperitoneal/rat | lowest published toxic dose: 20 mg/kg | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Biochemical: Metabolism (intermediary): Other | GEPHDP 18,165,1987 |
| intraperitoneal/rat | lowest published toxic dose: 3 mg/kg | Liver: Other changes Biochemical: Metabolism (intermediary): Lipids including transport Biochemical: Metabolism (intermediary): Other | FCLPH* 22(Suppl 1),52,2008 |
| intraperitoneal/Sunfish | lowest published toxic dose: 10 mg/kg | Brain and Coverings: Other degenerative changes | NRTXDN 31,356,2010 |
| intravenous/mouse | lethal dose (50 percent kill): 10500 µg/kg | TXAPA9 23,408,1972 | |
| intravenous/pigeon | lethal dose (50 percent kill): 1200 mg/kg | 32ZDAL -,79,1970 | |
| intravenous/rat | lowest published toxic dose: 45 mg/kg | Liver: Other changes Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | BCPCA6 67,2141,2004 |
| intravenous/rat | lethal dose (50 percent kill): 9 mg/kg | BJIMAG 21,269,1964 | |
| oral/cat | lowest published lethal dose: 500 mg/kg | Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion Liver: Fatty liver degeneration Kidney, Ureter, and Bladder: Other changes | CVETAA 2,71,1958 |
| oral/chicken | lethal dose (50 percent kill): 20 mg/kg | Eye: Miosis (pupilliary constriction) Behavioral: Excitement Behavioral: Food intake (animal) | JEENAI 44,1013,1951 |
| oral/Dog | lethal dose (50 percent kill): 65 mg/kg | GUCHAZ 6,198,1973 | |
| oral/duck | lethal dose (50 percent kill): 381 mg/kg | TXAPA9 20,57,1971 | |
| oral/guinea pig | lethal dose (50 percent kill): 49 mg/kg | PCOC** -,377,1966 | |
| oral/hamster | lethal dose (50 percent kill): 60 mg/kg | TJADAB 9,11,1974 | |
| oral/mammal (species unspecified) | lethal dose (50 percent kill): 94 mg/kg | Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral: Tremor Behavioral: Convulsions or effect on seizure threshold | NTIS** PB288-416 |
| oral/man | lowest published lethal dose: 65 mg/kg | 34ZIAG -,215,1969 | |
| oral/monkey | lethal dose (50 percent kill): 3 mg/kg | 32ZDAL -,79,1970 | |
| oral/mouse | lethal dose (50 percent kill): 38 mg/kg | SPEADM 78-1,13,1978 | |
| oral/pig | lethal dose (50 percent kill): 38 mg/kg | EJTXAZ 7,159,1974 | |
| oral/pigeon | lethal dose (50 percent kill): 23700 µg/kg | ASTTA8 (680),157,1979 | |
| oral/quail | lethal dose (50 percent kill): 10780 µg/kg | Behavioral: Altered sleep time (including change in righting reflex) Behavioral: Somnolence (general depressed activity) Behavioral: Irritability | ETOCDK 1,157,1982 |
| oral/rabbit | lethal dose (50 percent kill): 45 mg/kg | PCOC** -,377,1966 | |
| oral/rat | lowest published toxic dose: 30 mg/kg | Liver: Other changes Biochemical: Metabolism (intermediary): Lipids including transport | ENPBBC 5,119,1975 |
| oral/rat | lethal dose (50 percent kill): 38300 µg/kg | JAFCAU 3,402,1955 | |
| oral/wild bird | lethal dose (50 percent kill): 13300 µg/kg | ASTTA8 (680),157,1979 | |
| skin/cat | lowest published lethal dose: 750 mg/kg | Behavioral: Food intake (animal) Behavioral: Withdrawal Gastrointestinal: Nausea or vomiting | CVETAA 2,71,1958 |
| skin/rabbit | lethal dose (50 percent kill): 250 mg/kg | SPEADM 78-1,13,1978 | |
| skin/rat | lethal dose (50 percent kill): 56 mg/kg | RPZHAW 18,161,1967 | |
| subcutaneous/rabbit | lowest published lethal dose: 150 mg/kg | 85GMAT -,73,1982 | |
| subcutaneous/rat | lethal dose (50 percent kill): 49 mg/kg | 85GMAT -,73,1982 | |
| unreported route/Dog | lowest published lethal dose: 65 mg/kg | AMIHBC 3,64,1951 | |
| unreported route/human | lowest published lethal dose: 28 mg/kg | Cardiac: Other changes Lung, Thorax, or Respiration: Acute pulmonary edema | ATXKA8 22,115,1966 |
| unreported route/mammal (species unspecified) | lethal dose (50 percent kill): 25 mg/kg | 30ZDA9 -,63,1971 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| intraperitoneal/rat | lowest published toxic dose: 21 mg/kg/7D- intermittent | Liver: Other changes Biochemical: Metabolism (intermediary): Other | TXAPA9 19,234,1971 |
| oral/cat | lowest published toxic dose: 51 mg/kg/17D- intermittent | Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change Behavioral: Convulsions or effect on seizure threshold Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | CVETAA 2,71,1958 |
| oral/Dog | lowest published toxic dose: 27200 µg/kg/68W- intermittent | Liver: Changes in liver weight | JAFCAU 3,402,1955 |
| oral/domestic bird | lowest published toxic dose: 68 mg/kg/8W- continuous | Autonomic Nervous System: Sympathomimetic Liver: Changes in liver weight Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites | TXAPA9 53,75,1980 |
| oral/mammal (species unspecified) | lowest published toxic dose: 239 mg/kg/30D- continuous | Behavioral: Convulsions or effect on seizure threshold Skin and Appendages: Other: Hair Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | NTIS** PB288-416 |
| oral/mouse | lowest published toxic dose: 25 mg/kg/10D- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Endocrine: Androgenic Biochemical: Metabolism (intermediary): Other | ENVRAL 13,441,1977 |
| oral/mouse | lowest published toxic dose: 75600 µg/kg/18W- continuous | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation | EVHPAZ 39,79,1981 |
| oral/mouse | lowest published toxic dose: 840 µg/kg/2W- continuous | Immunological Including Allergic: Decrease in humoral immune response | EVHPAZ 39,79,1981 |
| oral/quail | lowest published toxic dose: 14 mg/kg/14D- continuous | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Metabolism (intermediary): Lipids including transport | POSCAL 53,54,1974 |
| oral/rabbit | lowest published toxic dose: 751 µg/kg/13W- continuous | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Immunological Including Allergic: Decrease in humoral immune response Biochemical: Metabolism (intermediary): Other proteins | BECTA6 10,42,1973 |
| oral/rat | lowest published toxic dose: 75 mg/kg/15D- continuous | Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases | TOLED5 11,131,1982 |
| oral/rat | lowest published toxic dose: 88 mg/kg/88D- continuous | Behavioral: Food intake (animal) Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases | JTEHD6 25,461,1988 |
| oral/rat | lowest published toxic dose: 140 mg/kg/8W- intermittent | Liver: Other changes Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases | TXAPA9 37,29,1976 |
| oral/rat | lowest published toxic dose: 109 mg/kg/2Y- continuous | Liver: Changes in liver weight | JAFCAU 3,402,1955 |
| oral/rat | lowest published toxic dose: 410 mg/kg/39W- continuous | Liver: Other changes Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | AMPLAO 64,614,1957 |
| oral/rat | lowest published toxic dose: 120 mg/kg/30D- intermittent | Brain and Coverings: Other degenerative changes Behavioral: Alteration of classical conditioning Behavioral: Aggression | TOXID9 44,432,2005 |
| oral/rat | lowest published toxic dose: 120 mg/kg/30D- intermittent | Gastrointestinal: Other changes Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | TOXID9 44,432,2005 |
| oral/rat | lowest published toxic dose: 60 mg/kg/30D- intermittent | Liver: Changes in liver weight | TOXID9 44,432,2005 |
| oral/rat | lowest published toxic dose: 30 mg/kg/30D- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) | TOXID9 44,432,2005 |
| oral/rat | lowest published toxic dose: 28 mg/kg/7D- intermittent | Behavioral: Food intake (animal) | TOXID9 44,432,2005 |
| oral/rat | lowest published toxic dose: 32.5 mg/kg/13D- intermittent | Liver: Other changes Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects | TOXID9 90,143,2006 |
| unreported route/mouse | lowest published toxic dose: 30 mg/kg/30D- intermittent | Brain and Coverings: Other degenerative changes Biochemical: Metabolism (intermediary): Other proteins Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum | TOXID9 90,227,2006 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 0.1 mg/m3 (inhal, vapor, skin) | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Not classifiable as a human carcinogen | DTLVS* TLV/BEI,2013 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Animal Limited Evidence | IMEMDT 5,125,1974 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Human Inadequate Evidence | IMEMDT 5,125,1974 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Group 3 | IMSUDL 7,196,1987 |
| TOXICOLOGY REVIEW | TOLED5 127,101,2002 | |
| TOXICOLOGY REVIEW | JSIRAC 34,462,1975 | |
| TOXICOLOGY REVIEW | DTTIAF 80,485,1973 | |
| TOXICOLOGY REVIEW | RREVAH 56,107,1975 | |
| TOXICOLOGY REVIEW | ECMAAI 14,141,1973 | |
| TOXICOLOGY REVIEW | BNYMAM 54,413,1978 | |
| TOXICOLOGY REVIEW | 85CVA2 5,250,1970 | |
| TOXICOLOGY REVIEW | 26UZAB 6,149,1968/1970 | |
| TOXICOLOGY REVIEW | EVHPAZ 109(Suppl 1),113,2001 | |
| TOXICOLOGY REVIEW | CTOXAO 13,231,1978 | |
| TOXICOLOGY REVIEW | EESADV 1,89,1977 | |
| TOXICOLOGY REVIEW | TXAPA9 10,613,1967 | |
| TOXICOLOGY REVIEW | EVHPAZ 109(Suppl 1),35,2001 | |
| TOXICOLOGY REVIEW | MUREAV 567,109,2004 | |
| TOXICOLOGY REVIEW | MUTAEX 21,93,2006 | |
| TOXICOLOGY REVIEW | NETOX* 26,701,2005 | |
| TOXICOLOGY REVIEW | NRTXDN 27,579,2006 | |
| TOXICOLOGY REVIEW | BPCEM* 16,105,2002 | |
| TOXICOLOGY REVIEW | ENTOX* -,15,2005 | |
| TOXICOLOGY REVIEW | ENTOX* -,334,2005 | |
| TOXICOLOGY REVIEW | MUREAV 584,1,2005 | |
| TOXICOLOGY REVIEW | HETOEA 25,413,2006 | |
| TOXICOLOGY REVIEW | JTEHD6 7,1,2004 | |
| TOXICOLOGY REVIEW | REPTED 23,457,2007 | |
| TOXICOLOGY REVIEW | JTPAE7 17,69,2004 | |
| TOXICOLOGY REVIEW | HTOPA* 1,501,2002 | |
| TOXICOLOGY REVIEW | TPHSDY 29,322,2008 | |
| TOXICOLOGY REVIEW | FCTOD7 46,813,2008 | |
| TOXICOLOGY REVIEW | MUREAV 674,3,2009 | |
| TOXICOLOGY REVIEW | MUREAV 674,36,2009 | |
| TOXICOLOGY REVIEW | MUREAV 674,73,2009 | |
| TOXICOLOGY REVIEW | MUTAEX 22,161,2007 | |
| TOXICOLOGY REVIEW | FESTAS 90,911,2008 | |
| TOXICOLOGY REVIEW | NEUCL* 23,485,2005 | |
| TOXICOLOGY REVIEW | MUREAV 705,184,2010 | |
| TOXICOLOGY REVIEW | NRTXDN 31,555,2010 | |
| TOXICOLOGY REVIEW | MUREAV 728,98,2011 | |
| TOXICOLOGY REVIEW | MUREAV 721,27,2011 | |
| TOXICOLOGY REVIEW | NRTXDN 32,383,2011 | |
| TOXICOLOGY REVIEW | REPTED 38,1,2013 | |
| TOXICOLOGY REVIEW | NRTXDN 33,833,2012 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 0.25 mg/m3 (skin) | DTLVS* 3,84,1971 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 0.25 mg/m3, JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 0.25 mg/m3;KZW 2.5 mg/m3, inhal, skin, 2007 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 0.25 mg/m3, Skin, MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 0.25 mg/m3, skin, carc, MAY2011 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 0.25 mg/m3, short term exposure limit 0.75 mg/m3, skin, NOV2011 | |
| Occupational Exposure Limit-FRANCE | VME 0.25 mg/m3, Skin, C3 Carcinogen, FEB2006 | |
| Occupational Exposure Limit-GERMANY | MAK 0.25 mg/m3, inhal, 2011 | |
| Occupational Exposure Limit-HUNGARY | time-weighted average 0.25 mg/m3 (resp), short term exposure limit 1 mg/m3 (resp), SEP2000 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 0.25 mg/m3, skin, NOV2011 | |
| Occupational Exposure Limit-INDIA | time-weighted average 0.25 mg/m3, Skin, JAN1993 | |
| Occupational Exposure Limit-KOREA | time-weighted average 0.25 mg/m3, skin, 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 0.25 mg/m3;short term exposure limit 0.75 mg/m3 (skin), 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 0.25 mg/m3, skin, JAN2002 | |
| Occupational Exposure Limit-NORWAY | time-weighted average 0.25 mg/m3, JAN1999 | |
| Occupational Exposure Limit-PERU | time-weighted average 0.25 mg/m3, JUL2005 | |
| Occupational Exposure Limit-POLAND | MAC(time-weighted average) 0.5 mg/m3, short term exposure limit 1.5 mg/m3, JAN1999 | |
| Occupational Exposure Limit-RUSSIA | short term exposure limit 0.01 mg/m3, JUN2003 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 0.25 mg/m3, carc 3, inhal, skin, JAN2011 | |
| Occupational Exposure Limit-THAILAND | time-weighted average 0.25 mg/m3, JAN1993 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 0.25 mg/m3, Skin, 2003 | |
| Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 0.25 mg/m3, Skin, JAN1993 | |
| Occupational Exposure Limit-TURKEY | time-weighted average 0.25 mg/m3, Skin, JAN1993 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 0.25 mg/m3 (skin) | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 0.25 mg/m3 (skin) | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 0.25 mg/m3 (skin) | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 0.25 mg/m3 (skin) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIELDRIN-air | Carcinogen time-weighted average 0.25 mg/m3 (Sk) (0.15 mg/m3 LOQ) | NIOSH* DHHS #92-100,1992 |
| National Occupational Hazard Survey 1974 | Hazard Code M2830; Number of Industries 2; Total Number of Facilities 56; Number of Occupations 3; Total Number of Employees Exposed 760 |
Status in Federal Agencies
| Organization | Reference |
|---|---|
| ATSDR TOXICOLOGY PROFILE (NTIS** PB/93/182368/AS) | |
| EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal | |
| EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test; S cerevisiae-homozygosis | |
| EPA GENETOX PROGRAM 1988, Negative: Rodent dominant lethal; Host-mediated assay | |
| EPA GENETOX PROGRAM 1988, Positive: V79 cell culture-gene mutation | |
| EPA TSCA Section 8(d) unpublished health/safety studies | |
| EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
| NCI Carcinogenesis Bioassay (feed);equivocal evidence:mouse | NCITR* NCI-TR-21,1978 |
| NCI Carcinogenesis Bioassay (feed);no evidence:rat | NCITR* NCI-TR-22,1978 |
| NCI Carcinogenesis Bioassay (feed);no evidence:rat | NCITR* NCI-TR-21,1978 |
| On EPA IRIS database |
- Page last reviewed:March 7, 2014
- Page last updated:February 6, 2017
- Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division