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Registry of Toxic Effects of Chemical Substances (RTECS)

1,4:5,8-Dimethanonaphthalene, 1,2,3,4,10,10-hexachloro-6,7-epoxy-1,4,4a,5,6,7,8,8a-octahydro-,endo,endo-

RTECS #

IO1575000

CAS #

72-20-8

Updated

September 201

Molecular Weight

380.90

Molecular Formula

C12H8Cl6O

Synonyms

Compound 269
EN 57
Endrex
Endricol
Endrin
Endrin (ACGIH:OSHA)
Endrine (French)
ENT 17,251
Experimental insecticide 269
Hexachloroepoxyoctahydro-endo,endo-dimethanonaphthalene
Hexadrin
Latka 269 (Czech)
Mendrin
NCI-C00157
Oktanex
OMS 197
RCRA waste number P051
SD 3419
Stardrin
Stardrin 20

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisparenteral/rat1 mg/kgBECTA6 9,65,1973
sister chromatid exchangemultiple/other fish54 pmol/LMUREAV 118,61,1983
sperm morphologyparenteral/rat10 mg/kg/10D-continuousAPTOA6 31,1,1972

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intratesticular/rat 10 mg/kg (10D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)APTOA6 31,1,1972
oral/mouse 10 mg/kg (8-12D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)JTEHD6 10,541,1982
oral/mouse 2500 µg/kg (9D pregnant)Reproductive: Specific developmental abnormalities: Eye, earTJADAB 9,11,1974
oral/mouse 2320 µg/kg (4D prior to copulation)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)		OYYAA2 6,673,1972
oral/mouse 7 mg/kg (8D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system		TCMUD8 5,3,1985
oral/mouse 16500 µg/kg (7-17D pregnant)Reproductive: Specific developmental abnormalities: Urogenital systemTXCYAC 21,141,1981
oral/hamster 15 mg/kg (5-14D pregnant)Reproductive: Effects on newborn: BehavioralTXCYAC 21,187,1981
oral/hamster 5 mg/kg (8D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death		TJADAB 9,11,1974
oral/hamster 5 mg/kg (8D pregnant)Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system		TJADAB 9,11,1974
oral/hamster 7500 µg/kg (5-14D pregnant)Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)TXAPA9 48,A200,1979
oral/hamster 5 mg/kg (8D pregnant)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Musculoskeletal system		TXAPA9 48,A201,1979
oral/rat 2320 µg/kg (4D prior to copulation)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Specific developmental abnormalities: Musculoskeletal system		OYYAA2 6,673,1972

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intracerebral/mouse lethal dose (50 percent kill): 400 µg/kgBehavioral: Convulsions or effect on seizure thresholdTOLED5 60,289,1992
intraperitoneal/mouse lethal dose (50 percent kill): 5 mg/kgTOLED5 60,289,1992
intravenous/mouse lethal dose (50 percent kill): 2300 µg/kgTXAPA9 23,408,1972
intravenous/pigeon lethal dose (50 percent kill): 1500 µg/kgBehavioral: Convulsions or effect on seizure thresholdTXAPA9 9,75,1966
oral/cat lowest published lethal dose: 5 mg/kgBehavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Cyanosis		JAFCAU 3,842,1955
oral/chicken lowest published lethal dose: 2 mg/kgBehavioral: Ataxia

Behavioral: Irritability		CNVJA9 11,74,1970
oral/Dog lowest published lethal dose: 20 mg/kgJFSCAS 29,331,1989
oral/duck lethal dose (50 percent kill): 5330 µg/kgTXAPA9 22,556,1972
oral/guinea pig lethal dose (50 percent kill): 16 mg/kgPCOC** -,475,1966
oral/hamster lethal dose (50 percent kill): 10 mg/kgTJADAB 9,11,1974
oral/man lowest published lethal dose: 171 mg/kgBehavioral: Convulsions or effect on seizure threshold

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Thrombocytopenia		HUTODJ 4,241,1985
oral/monkey lethal dose (50 percent kill): 3 mg/kgPCOC** -,475,1966
oral/mouse lowest published toxic dose: 137 µg/kgBrain and Coverings: Other degenerative changes

Liver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport		TXCYAC 175,73,2002
oral/mouse lethal dose (50 percent kill): 1370 µg/kgENTOX* -,176,2005
oral/pigeon lethal dose (50 percent kill): 5600 µg/kgTXAPA9 21,315,1972
oral/quail lethal dose (50 percent kill): 4210 µg/kgASTTA8 (680),157,1979
oral/rabbit lethal dose (50 percent kill): 7 mg/kgBehavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Cyanosis		JAFCAU 3,842,1955
oral/rat lethal dose (50 percent kill): 3 mg/kgWRPCA2 9,119,1970
oral/wild bird lethal dose (50 percent kill): 1780 µg/kgASTTA8 (680),157,1979
oral/woman lowest published lethal dose: 234 mg/kgBehavioral: Headache

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Body temperature increase		NEZAAQ 22,254,1967
skin/cat lowest published lethal dose: 75 mg/kgBehavioral: Food intake (animal)

Behavioral: Withdrawal

Gastrointestinal: Nausea or vomiting		CVETAA 2,71,1958
skin/rabbit lethal dose (50 percent kill): 60 mg/kgSPEADM 78-1,13,1978
skin/rat lethal dose (50 percent kill): 12 mg/kgSPEADM 78-1,13,1978
unreported route/rabbit lethal dose (50 percent kill): 7 mg/kg30ZDA9 -,64,1971
unreported route/rat lethal dose (50 percent kill): 17 mg/kg30ZDA9 -,64,1971

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 360 ppb/7H/22W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldJAFCAU 3,842,1955
inhalation/rabbit lowest published toxic concentration: 360 ppb/7H/24W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldJAFCAU 3,842,1955
oral/Dog lowest published toxic dose: 12150 µg/kg/81W- intermittentCardiac: Changes in heart weight

Kidney, Ureter, and Bladder: Changes in bladder weight		JAFCAU 3,842,1955
oral/rabbit lowest published toxic dose: 50 mg/kg/72D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldJAFCAU 3,842,1955
oral/rat lowest published toxic dose: 1975 mg/kg/79D- intermittentEye: Hemorrhage

Behavioral: Excitement

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		TXAPA9 14,556,1969
oral/rat lowest published toxic dose: 219 mg/kg/2Y- continuousLiver: Changes in liver weight

Nutritional and Gross Metabolic: Other changes		JAFCAU 3,842,1955
oral/rat lowest published toxic dose: 6720 mg/kg/16W- continuousBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		JAFCAU 4,696,1956
skin/rabbit lowest published toxic dose: 1400 mg/kg/14W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldJAFCAU 3,842,1955

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.1 mg/m3 (skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 5,157,1974
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 5,157,1974
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMSUDL 7,56,1987
TOXICOLOGY REVIEWTOLED5 127,101,2002
TOXICOLOGY REVIEWBECTA6 15,283,1976
TOXICOLOGY REVIEWCNDQA8 10(3),43,1975
TOXICOLOGY REVIEWRREVAH 56,107,1975
TOXICOLOGY REVIEWBNYMAM 54,413,1978
TOXICOLOGY REVIEWCTOXAO 13,231,1978
TOXICOLOGY REVIEW26UZAB 6,149,1968/1970
TOXICOLOGY REVIEWMUREAV 567,109,2004
TOXICOLOGY REVIEWMUTAEX 21,93,2006
TOXICOLOGY REVIEWENTOX* -,176,2005

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,180,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.1 mg/m3 (skin)DTLVS* 3,98,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypttime-weighted average 0.1 mg/m3, Skin, JAN1993
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.1 mg/m3, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.1 mg/m3;KZW 1 mg/m3, inhal, skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.1 mg/m3, Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.1 mg/m3, skin, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.1 mg/m3, short term exposure limit 0.3 mg/m3, skin, NOV2011
Occupational Exposure Limit-FRANCEVME 0.1 mg/m3, Skin, FEB2006
Occupational Exposure Limit-GERMANYMAK 0.05 mg/m3. inhal., skin, 2011
Occupational Exposure Limit-HUNGARYSkin, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 0.1 mg/m3, skin, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 0.1 mg/m3, skin, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.1 mg/m3;short term exposure limit 0.3 mg/m3 (skin), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.1 mg/m3, skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.1 mg/m3, JAN1999
Occupational Exposure Limit-PERUtime-weighted average 0,1 mg/m3, JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.5 mg/m3, MAC(short term exposure limit) 1.5 mg/m3, JAN1999
Occupational Exposure Limit-SWITZERLANDMAK-week 0.1 mg/m3, KZG-week 0.8 mg/m3, inhal, skin, JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 0.1 mg/m3, JAN1993
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.1 mg/m3, Skin, 2003
Occupational Exposure Limit-TURKEYtime-weighted average 0.1 mg/m3, Skin, JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.1 mg/m3 (skin)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 0.1 mg/m3 (skin)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 0.1 mg/m3 (skin)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.1 mg/m3 (skin)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ENDRIN-air10H time-weighted average 0.1 mg/m3 (Sk)NIOSH* DHHS #92-100,1992

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Negative/limited: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; TRP reversion
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,ratNCITR* NCI-TR-12,1979
NIOSH Analytical Method, 1994: Endrin, 5519
On EPA IRIS database

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