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Registry of Toxic Effects of Chemical Substances (RTECS)

1,3-Cyclopentadiene

RTECS #

GY1000000

CAS #

542-92-7

Updated

September 201

Molecular Weight

66.11

Molecular Formula

C5H6

Synonyms

Cyclopentadiene
Cyclopentadiene (ACGIH:OSHA)
Pentole
Pyropentylene
R-Pentine

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/human lowest published toxic concentration: 35 mg/m3Behavioral: HeadacheVCVGH* -,91,1990
inhalation/human lowest published toxic concentration: 360 mg/m3Lung, Thorax, or Respiration: DyspneaVCVGH* -,91,1990
inhalation/mouse lowest published toxic concentration: 15000 mg/m3Behavioral: General anestheticVCVGH* -,91,1990
inhalation/mouse lethal concentration (50 percent kill): 14 gm/m3Behavioral: Excitement

Behavioral: Muscle contraction or spasticity

Behavioral: Aggression		GTPZAB 9(12),13,1965
inhalation/mouse lethal concentration (16 percent kill): 9200 mg/m3VCVGH* -,91,1990
inhalation/mouse lethal concentration (50 percent kill): 11600 mg/m3VCVGH* -,91,1990
inhalation/mouse lethal concentration (84 percent kill): 17000 mg/m3VCVGH* -,91,1990
inhalation/rat lethal concentration (16 percent kill): 29000 mg/m3VCVGH* -,91,1990
inhalation/rat lethal concentration (50 percent kill): 35900 mg/m3VCVGH* -,91,1990
inhalation/rat lethal concentration (84 percent kill): 44000 mg/m3VCVGH* -,91,1990
inhalation/rat lethal concentration (50 percent kill): 39 gm/m3Behavioral: Excitement

Behavioral: Muscle contraction or spasticity

Behavioral: Aggression		GTPZAB 9(12),13,1965
inhalation/rat lowest published toxic concentration: 60000 mg/m3Behavioral: General anestheticVCVGH* -,91,1990
oral/mouse lethal dose (50 percent kill): 800 mg/kgTPKVAL 9,27,1967
oral/rat lethal dose (50 percent kill): 113 mg/kgNTIS** OTS0535718
skin/rabbit lethal dose (50 percent kill): 430 mg/kgNTIS** OTS0535718

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 350 mg/m3/4H/26W- intermittentBlood: Normocytic anemia

Blood: Changes in erythrocyte (RBC) count		GTPZAB 9(12),13,1965

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 75 ppmDTLVS* TLV/BEI,2013

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 75 ppm (200 mg/m3)DTLVS* 3,66,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 75 ppm (203 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 75 ppm (200 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 75 ppm (206 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 75 ppm (200 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 75 ppm (210 mg/m3), short term exposure limit 120 ppm (330 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 75 ppm (200 mg/m3), FEB2006
Occupational Exposure Limit-HUNGARYtime-weighted average 200 mg/m3, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 75 ppm (200 mg/m3), NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 75 ppm (200 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 75 ppm (200 mg/m3);short term exposure limit 150 ppm (400 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 75 ppm (203 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 40 ppm (110 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 75 ppm (203 mg/m3), JUL2005
Occupational Exposure Limit-POLANDtime-weighted average 200 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 5 mg/m3, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 75 ppm (200 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 200 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 75 ppm (200 mg/m3), JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 75 ppm (200 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 75 ppm (200 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 75 ppm (200 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 75 ppm (200 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CYCLOPENTADIENE-air10H time-weighted average 75 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 20065; Number of Industries 1; Total Number of Facilities 3; Number of Occupations 3; Total Number of Employees Exposed 51
National Occupational Hazard Survey 1974Hazard Code 20065; Number of Industries 19; Total Number of Facilities 3138; Number of Occupations 26; Total Number of Employees Exposed 18381

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: 1,3-Cyclopentadiene, 2523

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