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Registry of Toxic Effects of Chemical Substances (RTECS)

Cyclopentane

RTECS #

GY2390000

CAS #

287-92-3

Updated

September 201

Molecular Weight

70.15

Molecular Formula

C5H10

Synonyms

Cyclopentane (ACGIH)
Pentamethylene

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mammal (species unspecified) lowest published toxic concentration: 3440 mg/m3Lung, Thorax, or Respiration: Other changes

Liver: Other changes		TOVEFN (4),34,2000
inhalation/mouse lethal concentration (50 percent kill): 72 gm/m3Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold		TOVEFN (4),33,2000
inhalation/mouse Lowest published lethal concentration: 110000 mg/m3Behavioral: General anestheticVCVGH* -,81,1990
inhalation/rat lethal concentration (50 percent kill): 106000 mg/m3Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold		TOVEFN (4),34,2000
ocular/rabbit lowest published toxic dose: 100 pphEye: Conjunctiva irritationTOVEFN (4),34,2000
oral/mouse lethal dose (50 percent kill): 12800 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold		TOVEFN (4),34,2000
oral/rat lethal dose (50 percent kill): 11400 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold		TOVEFN (4),34,2000

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 34200 mg/kg/30D- intermittentKidney, Ureter, and Bladder: Renal function tests depressed

Blood: Other changes		TOVEFN (4),33,2000
oral/rat lowest published toxic dose: 34200 mg/kg/30D- intermittentKidney, Ureter, and Bladder: Renal function tests depressed

Blood: Changes in other cell count (unspecified)		TOVEFN (4),34,2000

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 600 ppmDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWMUREAV 539,77,2003

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 600 ppm (1720 mg/m3), JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 600 ppm (1800 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 300 ppm (850 mg/m3), MAY2011
Occupational Exposure Limit-FRANCEVME 600 ppm (1720 mg/m3), FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 300 ppm (850 mg/m3), NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 600 ppm (1720 mg/m3), 2006
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 600 ppm (1720 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 300 ppm (850 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 600 ppm (1721 mg/m3), JUL2005
Occupational Exposure Limit-SWITZERLANDMAK-week 600 ppm (1720 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 1720 mg/m3, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CYCLOPENTANE-air10H time-weighted average 600 ppmNIOSH* DHHS #95-121,1995
National Occupational Hazard Survey 1974Hazard Code 82935; Number of Industries 77; Total Number of Facilities 8027; Number of Occupations 52; Total Number of Employees Exposed 74753

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

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