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Registry of Toxic Effects of Chemical Substances (RTECS)

Cyclohexene

RTECS #

GW2500000

CAS #

110-83-8

Updated

September 201

Molecular Weight

82.16

Molecular Formula

C6H10

Synonyms

1,2,3,4-Tetrahydrobenzene
Benzene, tetrahydro-
Benzenetetrahydride
Cyclohex-1-ene
Cyclohexene (ACGIH:OSHA)
Cykloheksen (Polish)
Hexanaphthylene
Tetrahydrobenzene

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 30000 mg/m3Behavioral: General anestheticVCVGH* -,95,1990
inhalation/mouse lethal concentration (50 percent kill): 50000 mg/m3Vascular: BP lowering not characterized in autonomic section

Lung, Thorax, or Respiration: Respiratory obstruction		VCVGH* -,95,1990
inhalation/rat Lethal concentration: >6370 ppm/4HBehavioral: Tremor

Behavioral: Ataxia

Lung, Thorax, or Respiration: Other changes		NTIS** OTS0555329
inhalation/rat Lethal concentration: >6370 ppm/4HBehavioral: Tremor

Behavioral: Ataxia		HPV158 -,-,2007
oral/mouse lethal dose (50 percent kill): >3200 µL/kgBehavioral: Altered sleep time (including change in righting reflex)

Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia		NTIS** OTS0546026
oral/mouse lethal dose (50 percent kill): 2300 mg/kgVCVGH* -,95,1990
oral/rat lethal dose (50 percent kill): 1300 mg/kgVCVGH* -,95,1990
oral/rat lethal dose (16 percent kill): 920 mg/kgVCVGH* -,95,1990
oral/rat lethal dose (84 percent kill): 3800 mg/kgVCVGH* -,95,1990
oral/rat lowest published toxic dose: 400 mg/kgNutritional and Gross Metabolic: Weight loss or decreased weight gain

Nutritional and Gross Metabolic: Changes in: Metabolic acidosis

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase		VCVGH* -,95,1990
oral/rat lowest published lethal dose: 2000 mg/kgBehavioral: Tremor

Lung, Thorax, or Respiration: Acute pulmonary edema

Gastrointestinal: Changes in structure or function of salivary glands		HPV158 -,-,2007
oral/rat lethal dose (50 percent kill): 2400 µL/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Behavioral: Ataxia		NTIS** OTS0546026
skin/guinea pig lethal dose (50 percent kill): >20 mL/kgHPV158 -,-,2007
unreported route/rat lethal dose (50 percent kill): 2 gm/kgGTPZAB 29(12),53,1985

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 600 ppm/6H/26W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases		TXAPA9 37,155,1976
oral/rat lowest published toxic dose: 7200 mg/kg/48D- intermittentGastrointestinal: Changes in structure or function of salivary glandsHPV158 -,-,2007
oral/rat lowest published toxic dose: 24000 mg/kg/48D- intermittentGastrointestinal: Changes in structure or function of salivary glands

Kidney, Ureter, and Bladder: Changes in kidney weight		HPV158 -,-,2007
oral/rat lowest published toxic dose: 6300 mg/kg/42D- intermittentGastrointestinal: Changes in structure or function of salivary glandsHPV158 -,-,2007

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 300 ppmDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWENTOX* -,707,2005

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 300 ppm (1015 mg/m3)DTLVS* 3,66,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 300 ppm (1010 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 300 ppm (1015 mg/m3);KZW 1200 ppm (4060 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 300 ppm (1025 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 300 ppm (1015 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 300 ppm (1000 mg/m3), short term exposure limit 380 ppm (1300 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 300 ppm (1015 mg/m3), FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 300 ppm (1015 mg/m3), NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 300 ppm (1050 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 300 ppm (1015 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 300 ppm (1.01 mg/m3), JAN2002
Occupational Exposure Limit-PERUtime-weighted average 300 ppm (1008 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 300 mg/m3, MAC(short term exposure limit) 900 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 50 mg/m3, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 300 ppm (1015 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 1015 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 300 ppm (1015 mg/m3), JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 300 ppm (1050 mg/m3), JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 300 ppm (1015 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 300 ppm (1015 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 300 ppm (1015 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 300 ppm (1015 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CYCLOHEXENE-air10H time-weighted average 300 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 21705; Number of Industries 1; Total Number of Facilities 40; Number of Occupations 1; Total Number of Employees Exposed 517; Total Number of Female Employees Exposed 239
National Occupational Hazard Survey 1974Hazard Code 21705; Number of Industries 1; Total Number of Facilities 16; Number of Occupations 7; Total Number of Employees Exposed 529

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Hydrocarbons, BP 36-126 degree C, 1500

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