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Registry of Toxic Effects of Chemical Substances (RTECS)

Cyclohexanone, 2-methyl-

RTECS #

GW1750000

CAS #

583-60-8

Updated

September 201

Molecular Weight

112.19

Molecular Formula

C7H12O

Synonyms

2-Methyl-cyclohexanon (German, Dutch)
alpha-Methylcyclohexanone
o-Methylcyclohexanone

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat Lowest published lethal concentration: 2800 ppm/4HAIHAAP 30,470,1969
intraperitoneal/mouse lethal dose (50 percent kill): 200 mg/kgNTIS** AD691-490
intravenous/mouse lowest published lethal dose: 270 mg/kgCardiac: Change in rate

Vascular: BP lowering not characterized in autonomic section		COREAF 236,633,1953
oral/rat lethal dose (50 percent kill): 2140 µL/kgAIHAAP 30,470,1969
skin/rabbit lethal dose (50 percent kill): 1770 µL/kgAIHAAP 30,470,1969

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 50 ppm;short term exposure limit 75 ppm (skin)DTLVS* TLV/BEI,2013

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 50 ppm (230 mg/m3) (skin)DTLWS* 3,23,1973
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 50 ppm (229 mg/m3), short term exposure limit 75 ppm (344 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 50 ppm (230 mg/m3);KZW 200 ppm (920 mg/m3), skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 50 ppm (232 mg/m3), MAR2002
Occupational Exposure Limit-BELGIUMshort term exposure limit 75 ppm (349 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 50 ppm (230 mg/m3), skin, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 50 ppm (230 mg/m3), short term exposure limit 75 ppm (350 mg/m3), skin, NOV2011
Occupational Exposure Limit-FRANCEVME 50 ppm (230 mg/m3), Skin, FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 50 ppm (230 mg/m3), skin, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 50 ppm (230 mg/m3), short term exposure limit 75 ppm (345 mg/m3), skin, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 50 ppm (230 mg/m3);short term exposure limit 75 ppm (skin), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 50 ppm (229 mg/m3); short term exposure limit 75 ppm (344 mg/m3), skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 25 ppm (115 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 50 ppm (229 mg/m3); short term exposure limit 75 ppm (344 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 50 mg/m3, MAC(short term exposure limit) 340 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 50 ppm, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 50 ppm (230 mg/m3), KZG-week 100 ppm (460 mg/m3), skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 230 mg/m3, Skin, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 100 ppm (460 mg/m3), Skin, JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 100 ppm (460 mg/m3), Skin, JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 50 ppm (233 mg/m3);short term exposure limit 75 ppm (350 mg/m3), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 100 ppm (460 mg/m3) (skin)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 100 ppm (460 mg/m3) (skin)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 100 ppm (460 mg/m3) (skin)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 100 ppm (460 mg/m3) (skin)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO THE CHEMICAL-air10H time-weighted average 50 ppm (Sk);short term exposure limit 75 ppm (Sk)NIOSH* DHHS #92-100,1992

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
NIOSH Analytical Method, 1994: Methylcyclohexanone, 2521

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