Registry of Toxic Effects of Chemical Substances (RTECS)
ShareCompartir
Carbamic acid, methyl-, 1-naphthyl ester
RTECS #
FC5950000CAS #
63-25-2; 11095-11-7; 52001-89-5Updated
September 201Molecular Weight
201.24Molecular Formula
C12H11NO2Synonyms
1-Naftylester kyseliny methylkarbaminove (Czech)1-Naphthalenol, methylcarbamate (9CI)
1-Naphthalenyl methylcarbamate
1-Naphthol N-methylcarbamate
1-Naphthyl methylcarbamate
1-Naphthyl N-methylcarbamate
1-Naphthyl-N-methyl-karbamat (German)
alpha-Naftyl-N-methylkarbamat (Czech)
alpha-Naphthalenyl methylcarbamate
alpha-Naphthyl N-methylcarbamate
Arilat
Arilate
Arylam
Atoxan
Bug master
Carbaril
Carbaryl
Carbaryl (ACGIH:OSHA)
Carbatox
Carbatox-60
Carbatox-75
Carbavur
Carbomate
Carylderm
Cekubaryl
Compound 7744
Crunch
Denapon
Dicarbam
Dyna-carbyl
ENT 23,969
Experimental Insecticide 7744
Germain's
Hexavin
Karbaryl (Polish)
Karbatox
Karbatox 75
Karbatox zawiesinowy
Karbosep
Latka 7744 (Czech)
Menaphtam
Methylcarbamic acid, 1-naphthyl ester
Monsur
Mugan
Murvin
NAC (insecticide)
NMC 50
N-Methyl-1-naftyl-carbamaat (Dutch)
N-Methyl-1-naphthyl carbamate
N-Methyl-1-naphthyl-carbamat (German)
N-Methyl-alpha-naphthylcarbamate
N-Methyl-alpha-naphthylurethan
N-Methylcarbamate de 1-naphtyle (French)
N-Metil-1-naftil-carbammato (Italian)
Oltitox
OMS-29
Panam
Pomex
Prosevor 85
Ravyon
Savit
Seffein
Sevimol
Sevin
Sevin (OSHA)
Sevin 4
Tercyl
Toxan
Tricarnam
UC 7744
Union carbide 7,744
Vetox
Vioxan
Skin and Eye Irritation and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| eye /rabbit | 500 mg/24H | mild | 85JCAE -,955,1986 |
| skin /rabbit | 12 mg/24H | severe | JAFCAU 9,30,1961 |
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| Cytogenetic Analysis | parenteral/grasshopper | 100 pph | CUSCAM 43,187,1974 |
| Cytogenetic Analysis | embryo/human | 40 mg/L | ZDVKAP 20(4),14,1977 |
| Cytogenetic Analysis | fibroblast/hamster | 30 mg/L/48H | MUREAV 48,337,1977 |
| Cytogenetic Analysis | lung/hamster | 100 µmol/L | MUREAV 119,319,1983 |
| DNA inhibition | other cell types/rat | 1 mg/L | ARTODN 45,101,1980 |
| DNA inhibition | Ascites tumor/mouse | 100 µmol/L | BECTA6 14,441,1975 |
| DNA inhibition | lymphocyte/human | 50 mg/L | ARTODN 45,101,1980 |
| DNA inhibition | lung/human | 1 mmol/L | NNGADV 8,353,1983 |
| host-mediated assay | Ascites tumor/mouse | 60 mg/kg/5D- intermittent | BECTA6 14,441,1975 |
| micronucleus test | multiple/non-mammalian species | 5 ppm/8D-continuous | MUREAV 125,275,1984 |
| mutation in mammalian somatic cells | lung/hamster | 10 µmol/L | CBINA8 19,369,1977 |
| mutation in microorganisms | /Saccharomyes cerevisiae | 100 ppm (-enzymatic activation step) | RSTUDV 6,161,1976 |
| mutation in microorganisms | /Salmonella typhimurium | 250 µg/plate (+enzymatic activation step) | RPZHAW 30,81,1979 |
| mutation in microorganisms | /Salmonella typhimurium | 100 µmol/L (-enzymatic activation step) | ARTODN 39,159,1977 |
| mutation in microorganisms | /Other microorganisms | 5 mg/L (-enzymatic activation step) | JASIAB 104,571,1985 |
| other mutation test systems | lung/human | 1 mmol/L | NNGADV 8,353,1983 |
| other mutation test systems | fibroblast/human | 100 mg/kg | GTPZAB 17(3),32,1973 |
| other mutation test systems | Ascites tumor/mouse | 400 µmol/L | BECTA6 14,441,1975 |
| sex chromosome loss and nondisjunction | oral/Drosophila melanogaster | 1 pph/24H | SOGEBZ 8,798,1972 |
| sex chromosome loss and nondisjunction | lung/hamster | 50 µmol/L | MUREAV 119,319,1983 |
| sperm morphology | intraperitoneal/mouse | 1 mmol/L | BSRSA6 45,46,1976 |
| sperm morphology | oral/mouse | 1 mmol/L | BSRSA6 45,46,1976 |
| Unscheduled DNA Synthesis | fibroblast/human | 1 µmol/L | MUREAV 42,161,1977 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/rat | 1370 mg/kg (39W prior to copulation) | Reproductive: Maternal effects: Menstrual cycle changes or disorders | VPITAR 27(6),49,1968 |
| oral/rat | 5500 mg/kg (multigenerations) | Reproductive: Effects on fertility: Other measures of fertility | TXAPA9 17,273,1970 |
| oral/rat | 27500 µg/kg (multigenerations) | Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | TXAPA9 21,390,1972 |
| oral/rat | 220 mg/kg (5-15D pregnant) | Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4) | TXAPA9 21,390,1972 |
| oral/rat | 1370 mg/kg (39W male) | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | VPITAR 27(6),49,1968 |
| oral/rat | 5475 mg/kg (52W prior to copulation) | Reproductive: Maternal effects: Ovaries, fallopian tubes Reproductive: Maternal effects: Uterus, cervix, vagina Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) | VPITAR 27(6),49,1968 |
| oral/rat | 3250 mg/kg (13W male) | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | VHTODE 37,421,1995 |
| oral/mouse | 11660 mg/kg (6-15D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | TXAPA9 51,81,1979 |
| oral/mouse | 100 mg/kg (8D pregnant) | Reproductive: Specific developmental abnormalities: Musculoskeletal system Reproductive: Specific developmental abnormalities: Urogenital system | FCTOD7 29,629,1991 |
| oral/mouse | 200 mg/kg (8D pregnant) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) | FCTOD7 29,629,1991 |
| oral/mouse | 150 mg/kg (8D pregnant) | Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Specific developmental abnormalities: Eye, ear | FCTOD7 29,629,1991 |
| oral/Dog | 375 mg/kg (3-62D pregnant) | Reproductive: Specific developmental abnormalities: Body wall Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) Reproductive: Specific developmental abnormalities: Hepatobiliary system | TXAPA9 13,392,1968 |
| oral/Dog | 750 mg/kg (3-62D pregnant) | Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4) | TXAPA9 13,392,1968 |
| oral/Dog | 197 mg/kg (1-63D pregnant) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on newborn: Stillbirth | 32OAAP -,253,1973 |
| oral/Dog | 394 mg/kg (1-63D pregnant) | Reproductive: Specific developmental abnormalities: Musculoskeletal system Reproductive: Specific developmental abnormalities: Gastrointestinal system | 32OAAP -,253,1973 |
| oral/rabbit | 1950 mg/kg (6-18D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Other effects on female Nutritional and Gross Metabolic: Weight loss or decreased weight gain | TXAPA9 51,81,1979 |
| oral/rabbit | 2600 mg/kg (6-18D pregnant) | Reproductive: Specific developmental abnormalities: Body wall | TXAPA9 51,81,1979 |
| oral/pig | 912 mg/kg (1-16W pregnant) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) | 32OAAP -,253,1973 |
| oral/guinea pig | 300 mg/kg (12-16D pregnant) | Reproductive: Specific developmental abnormalities: Musculoskeletal system | TXAPA9 15,152,1969 |
| oral/hamster | 250 mg/kg (8D pregnant) | Reproductive: Effects on embryo or fetus: Fetal death | TXAPA9 15,152,1969 |
| oral/gerbil | 12500 mg/kg (multigenerations) | Reproductive: Effects on fertility: Other measures of fertility | TXAPA9 17,273,1970 |
| oral/gerbil | 20300 mg/kg (multigenerations) | Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4) | TXAPA9 19,202,1971 |
| oral/gerbil | 20300 mg/kg (multigenerations) | Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) | TXAPA9 19,202,1971 |
| oral/gerbil | 40600 mg/kg (multigenerations) | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | TXAPA9 19,202,1971 |
| oral/rat | 375 mg/kg (14-22D preg/7D after birth) | Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4) | TOXID9 36,344,1997 |
| subcutaneous/mouse | 900 mg/kg (6-15D pregnant) | Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Specific developmental abnormalities: Eye, ear Reproductive: Specific developmental abnormalities: Musculoskeletal system | NTIS** PB223-160 |
| subcutaneous/mouse | 900 mg/kg (6-14D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | NTIS** PB223-160 |
| subcutaneous/mouse | 418 mg/kg (6-14D pregnant) | Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord) | NTIS** PB223-160 |
| subcutaneous/mouse | 4176 mg/kg (6-14D pregnant) | Reproductive: Effects on embryo or fetus: Fetal death | NTIS** PB223-160 |
Tumorigenic Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| implant/rat | lowest published toxic dose: 80 mg/kg | Tumorigenic: Carcinogenic by RTECS criteria Skin and Appendages: Tumors Tumorigenic: Tumors at site of application | VPITAR 29,71,1970 |
| oral/rat | lowest published toxic dose: 5640 mg/kg/94W- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Gastrointestinal: Tumors Skin and Appendages: Tumors | VPITAR 29,71,1970 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| In Vitro/Rat, neurons | Inhibitor Concentration Low: 25 mg/L/2H | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TIVIEQ 3,111,1989 |
| In Vitro/Rat, neurons | Inhibitor Concentration (50 percent kill): 17 mmol/L/2H | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TIVIEQ 3,111,1989 |
| inhalation/cat | lowest published toxic concentration: 40 mg/m3 | Behavioral: Change in motor activity (specific assay) | HBPTO* 2,1099,2001 |
| inhalation/guinea pig | Lethal concentration: >390 mg/m3/4H | UCDS** 11/21/1973 | |
| inhalation/rat | lethal concentration (50 percent kill): 5 mg/m3 | HBPTO* 2,1094,2001 | |
| inhalation/rat | lowest published toxic concentration: 300 mg/m3/15M | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOXID9 -,175,2009 |
| inhalation/rat | lowest published toxic concentration: 30 mg/m3/3H | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOXID9 -,175,2009 |
| intramuscular/monkey | lowest published toxic dose: 3 mg/kg | Peripheral Nerve and Sensation: Recording from peripheral motor nerve Peripheral Nerve and Sensation: Structural change in nerve or sheath | HBPTO* 2,1100,2001 |
| intramuscular/rat | lowest published toxic dose: 3 mg/kg | Behavioral: Alteration of operant conditioning | HBPTO* 2,1095,2001 |
| intraperitoneal/hamster | lethal dose (50 percent kill): 640 mg/kg | ARTODN 58,152,1986 | |
| intraperitoneal/mouse | lethal dose (50 percent kill): 25 mg/kg | TXAPA9 6,402,1964 | |
| intraperitoneal/rabbit | lethal dose (50 percent kill): 223 mg/kg | JAFCAU 9,30,1961 | |
| intraperitoneal/rat | lethal dose (50 percent kill): 64 mg/kg | PSEBAA 114,509,1963 | |
| intraperitoneal/rat | lowest published toxic dose: 7.3 mg/kg | Behavioral: Change in psychophysiological tests | HBPTO* 2,1099,2001 |
| intravenous/rat | lethal dose (50 percent kill): 18 mg/kg | JAFCAU 9,30,1961 | |
| oral/cat | lethal dose (50 percent kill): 150 mg/kg | Behavioral: Convulsions or effect on seizure threshold Behavioral: Muscle weakness Gastrointestinal: Changes in structure or function of salivary glands | GISAAA 32(4),29,1967 |
| oral/cat | lethal dose (50 percent kill): 125 mg/kg | HBPTO* 2,1094,2001 | |
| oral/Dog | lethal dose (50 percent kill): 250 mg/kg | HBPTO* 2,1094,2001 | |
| oral/gerbil | lethal dose (50 percent kill): 491 mg/kg | PCBPBS 21,199,1984 | |
| oral/guinea pig | lethal dose (50 percent kill): 250 mg/kg | PCBPBS 21,199,1984 | |
| oral/hamster | lowest published lethal dose: 250 mg/kg | TXAPA9 15,152,1969 | |
| oral/human | lowest published toxic dose: 2.8 mg/kg | Gastrointestinal: Nausea or vomiting Gastrointestinal: Other changes | HBPTO* 2,1096,2001 |
| oral/mammal (species unspecified) | lethal dose (50 percent kill): 510 mg/kg | HPBIA9 21,53,1975 | |
| oral/man | lowest published toxic dose: 500 mg/kg | Peripheral Nerve and Sensation: Sensory change involving peripheral nerve Behavioral: Muscle weakness | NEURAI 37,1229,1987 |
| oral/monkey | lethal dose (50 percent kill): 1000 mg/kg | HBPTO* 2,1094,2001 | |
| oral/mouse | lethal dose (50 percent kill): 108 mg/kg | HBPTO* 2,1094,2001 | |
| oral/pig | lowest published toxic dose: 20 mg/kg | Behavioral: Change in psychophysiological tests | HBPTO* 2,1098,2001 |
| oral/pig | lethal dose (50 percent kill): 1500 mg/kg | HBPTO* 2,1094,2001 | |
| oral/quail | lethal dose (50 percent kill): 829 mg/kg | Behavioral: Convulsions or effect on seizure threshold Behavioral: Ataxia Gastrointestinal: Changes in structure or function of salivary glands | OYYAA2 51,137,1996 |
| oral/rabbit | lethal dose (50 percent kill): 710 mg/kg | HBPTO* 2,1094,2001 | |
| oral/rat | lethal dose (50 percent kill): 233 mg/kg | HBPTO* 2,1094,2001 | |
| oral/rat | lowest published toxic dose: 0.56 mg/kg | Behavioral: Change in psychophysiological tests | HBPTO* 2,1100,2001 |
| oral/rat | lethal dose (50 percent kill): 230 mg/kg | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TXAPA9 11,546,1967 |
| oral/rat | lowest published toxic dose: 15 mg/kg | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TXCYAC 276,172,2010 |
| oral/rat | lowest published toxic dose: 75 mg/kg | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic: Body temperature decrease Biochemical: Metabolism (intermediary): Other | NRTXDN 30,377,2009 |
| oral/rat | lowest published toxic dose: 75 mg/kg | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) | TOXID9 -,337,2009 |
| oral/rat | lowest published toxic dose: 50 mg/kg | Brain and Coverings: Changes in surface EEG Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOXID9 -,441,2009 |
| oral/rat | lowest published toxic dose: 50 mg/kg | Behavioral: Tremor Behavioral: Alteration of classical conditioning Gastrointestinal: Changes in structure or function of salivary glands | TOXID9 44,224,2005 |
| oral/rat | lowest published toxic dose: 15 mg/kg | Behavioral: Change in motor activity (specific assay) Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOXID9 66,321,2002 |
| oral/rat | lowest published toxic dose: 10 mg/kg | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases | TXCYAC 217,1,2006 |
| oral/rat | lowest published toxic dose: 50 mg/kg | Behavioral: Tremor Nutritional and Gross Metabolic: Body temperature decrease Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases | TXCYAC 217,1,2006 |
| oral/rat | lowest published lethal dose: 75 mg/kg | Behavioral: Tremor Nutritional and Gross Metabolic: Body temperature decrease Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases | TXCYAC 217,1,2006 |
| oral/rat | lowest published toxic dose: 3 mg/kg | Behavioral: Change in motor activity (specific assay) | TOXID9 90,302,2006 |
| oral/rat | lowest published toxic dose: 3 mg/kg | Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | NRTXDN 29,87,2008 |
| oral/rat | lowest published toxic dose: 75 mg/kg | Brain and Coverings: Recordings from specific areas of CNS | NRTXDN 29,87,2008 |
| oral/rat | lowest published toxic dose: 30 mg/kg | Nutritional and Gross Metabolic: Body temperature decrease | NRTXDN 29,87,2008 |
| oral/rat | lowest published toxic dose: 30 mg/kg | Peripheral Nerve and Sensation: Fasciculations Behavioral: Somnolence (general depressed activity) Behavioral: Tremor | TOXID9 12,478,2008 |
| oral/wild bird | lethal dose (50 percent kill): 56 mg/kg | TXAPA9 21,315,1972 | |
| oral/woman | lowest published lethal dose: 5 gm/kg | Autonomic Nervous System: Parasympatholytic Cardiac: Change in rate Nutritional and Gross Metabolic: Other changes | HETOEA 11,373,1992 |
| skin/rabbit | lethal dose (50 percent kill): 2 gm/kg | 85DPAN -,-,1971/1976 | |
| skin/rat | lethal dose (50 percent kill): 4 gm/kg | 85DPAN -,-,1971/1976 | |
| subcutaneous/chicken | lowest published lethal dose: 2 gm/kg | JAFCAU 9,30,1961 | |
| subcutaneous/mouse | lethal dose (50 percent kill): 860 mg/kg | AHRTAN 29,251,1978 | |
| subcutaneous/rabbit | Lethal dose: >2 gm/kg | JAFCAU 9,30,1961 | |
| subcutaneous/rat | lethal dose (50 percent kill): 1400 mg/kg | 34ZIAG -,528,1969 | |
| Tank with water/Lugworm | lethal concentration (50 percent kill): 7.2 mg/L/48H | AQUTO* 10,235,1987 | |
| Tank with water/Shrimp | lethal concentration (50 percent kill): 12 µg/L/96H | EESADV 73,360,2010 | |
| unreported route/mammal (species unspecified) | lethal dose (50 percent kill): 310 mg/kg | GISAAA 53(7),72,1988 | |
| unreported route/mouse | lethal dose (50 percent kill): 370 mg/kg | GISAAA 49(10),23,1984 | |
| unreported route/rat | lethal dose (50 percent kill): 500 mg/kg | 30ZDA9 -,188,1971 | |
| unreported route/rat | lowest published toxic dose: 80 mg/kg | Behavioral: Change in motor activity (specific assay) | TOXID9 72,128,2003 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/cat | lowest published toxic concentration: 63 mg/kg/4W- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | GISAAA 32(4),29,1967 |
| inhalation/rat | lowest published toxic concentration: 214 µg/m3/24H/13W- intermittent | Brain and Coverings: Recordings from specific areas of CNS Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | GISAAA 53(7),72,1988 |
| inhalation/rat | lowest published toxic concentration: 12 mg/m3/6H/16W- intermittent | Behavioral: Change in psychophysiological tests | HBPTO* 2,1100,2001 |
| inhalation/rat | lowest published toxic concentration: 23 mg/m3/4H/17W- intermittent | Brain and Coverings: Recordings from specific areas of CNS Behavioral: Change in motor activity (specific assay) Behavioral: Alteration of classical conditioning | GISAAA 43(11),33,1978 |
| oral/mouse | lowest published toxic dose: 11.4 gm/kg/16D- continuous | Behavioral: Food intake (animal) | FCTOD7 41,99,2003 |
| oral/mouse | lowest published toxic dose: 15.2 gm/kg/20D- continuous | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | FCTOD7 41,99,2003 |
| oral/mouse | lowest published toxic dose: 32.22 gm/kg/180D- continuous | Liver: Changes in liver weight Endocrine: Changes in thymus weight | FCTOD7 41,99,2003 |
| oral/mouse | lowest published toxic dose: 3222 mg/kg/180D- continuous | Kidney, Ureter, and Bladder: Other changes | FCTOD7 41,99,2003 |
| oral/mouse | lowest published toxic dose: 16.8 gm/kg/7D- intermittent | Behavioral: Fluid intake Behavioral: Change in motor activity (specific assay) Behavioral: Aggression | BECTA6 71,37,2003 |
| oral/pig | lowest published toxic dose: 8157 mg/kg/72D- intermittent | Brain and Coverings: Other degenerative changes Spinal Cord: Other degenerative changes Musculoskeletal: Other changes | TXAPA9 14,409,1969 |
| oral/pig | lowest published toxic dose: 9.6 gm/kg/46D- intermittent | Peripheral Nerve and Sensation: Structural change in nerve or sheath Behavioral: Ataxia Behavioral: Muscle contraction or spasticity | HBPTO* 2,1098,2001 |
| oral/quail | lowest published toxic dose: 13230 mg/kg/14W- continuous | Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in bladder weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | BECTA6 17,360,1977 |
| oral/rabbit | lowest published toxic dose: 7.59 mg/kg/33D- continuous | Immunological Including Allergic: Decrease in humoral immune response | TXAPA9 32,587,1975 |
| oral/rabbit | lowest published toxic dose: 131.1 mg/kg/57D- continuous | Endocrine: Other changes | TXAPA9 32,587,1975 |
| oral/rat | lowest published toxic dose: 4725 mg/kg/21D- intermittent | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects | FCTOD7 47,86,2009 |
| oral/rat | lowest published toxic dose: 4725 mg/kg/21D- intermittent | Liver: Other changes Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects | FCTOD7 47,86,2008 |
| oral/rat | lowest published toxic dose: 720 mg/kg/10D- intermittent | Biochemical: Neurotransmitters or modulators (putative): Catecholamine levels in CNS Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites | GISAAA 49(5),80,1984 |
| oral/rat | lowest published toxic dose: 300 mg/kg/50D- continuous | Brain and Coverings: Recordings from specific areas of CNS Brain and Coverings: Other degenerative changes Biochemical: Metabolism (intermediary): Other proteins | TXAPA9 27,465,1974 |
| oral/rat | lowest published toxic dose: 30 mg/kg/30D- intermittent | Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) | BECTA6 23,438,1979 |
| oral/rat | lowest published toxic dose: 1050 mg/kg/21D- intermittent | Liver: Other changes Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases | AECTCV 14,459,1985 |
| oral/rat | lowest published toxic dose: 10800 mg/kg/96D- continuous | Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in bladder weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | JAFCAU 9,30,1961 |
| oral/rat | lowest published toxic dose: 25480 mg/kg/1Y- intermittent | Endocrine: Evidence of thyroid hypofunction Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | FCTXAV 6,461,1968 |
| oral/rat | lowest published toxic dose: 1109 mg/kg/22W- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphokinase Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes | GISAAA 35(7),97,1970 |
| oral/rat | lowest published toxic dose: 500 mg/kg/50D- continuous | Behavioral: Change in psychophysiological tests | HBPTO* 2,1100,2001 |
| unreported route/quail | lowest published toxic dose: 50 µg/kg/5D- intermittent | Immunological Including Allergic: Decreased immune response | HBPTO* 1,775,2001 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 5 mg/m3 (skin) | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Not classifiable as a human carcinogen | DTLVS* TLV/BEI,2013 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Animal Inadequate Evidence | IMEMDT 12,37,1976 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Human No Adequate Data | IMEMDT 12,37,1976 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Group 3 | IMSUDL 7,56,1987 |
| TOXICOLOGY REVIEW | CNDQA8 10(3),43,1975 | |
| TOXICOLOGY REVIEW | DTTIAF 80,485,1973 | |
| TOXICOLOGY REVIEW | RREVAH 63,1,1976 | |
| TOXICOLOGY REVIEW | 85ALAU -,106,1977 | |
| TOXICOLOGY REVIEW | MUTAEX 21,93,2006 | |
| TOXICOLOGY REVIEW | ENTOX* -,588,2005 | |
| TOXICOLOGY REVIEW | MUREAV 584,1,2005 | |
| TOXICOLOGY REVIEW | JTEHD6 7,1,2004 | |
| TOXICOLOGY REVIEW | FEREAC 73,29456,2008 | |
| TOXICOLOGY REVIEW | REPTED 26,1,2008 | |
| TOXICOLOGY REVIEW | MUREAV 681,3,2009 | |
| TOXICOLOGY REVIEW | FEREAC 73,64229,2008 | |
| TOXICOLOGY REVIEW | FEREAC 73,52607,2008 | |
| TOXICOLOGY REVIEW | REPTED 26,13,2008 | |
| TOXICOLOGY REVIEW | HETOEA 26,321,2007 | |
| TOXICOLOGY REVIEW | NTAPM* -,711,1995 | |
| TOXICOLOGY REVIEW | TOLED5 190,107,2009 | |
| TOXICOLOGY REVIEW | REPTED 31,392,2011 | |
| TOXICOLOGY REVIEW | MUREAV 721,27,2011 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION | FEREAC 54,7740,1989 | |
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES | Supported | RBREV* -,94,1998 |
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 5 mg/m3 | DTLVS* 3,37,1971 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-ARAB Republic of Egypt | time-weighted average 5 mg/m3, JAN1993 | |
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 5 mg/m3, JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 5 mg/m3, inhal, skin, 2007 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 5 mg/m3, MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 5 mg/m3, skin, carc, MAY2011 | |
| Occupational Exposure Limit-FRANCE | VME 5 mg/m3, C3 Carcinogen, FEB2006 | |
| Occupational Exposure Limit-HUNGARY | time-weighted average 1 mg/m3, SEP2000 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 5 mg/m3, skin, NOV2011 | |
| Occupational Exposure Limit-JAPAN | Occupational Exposure Limit 5 mg/m3, skin, MAY2012 | |
| Occupational Exposure Limit-KOREA | time-weighted average 5 mg/m3, 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 5 mg/m3;short term exposure limit 10 mg/m3, 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 5 mg/m3, JAN2002 | |
| Occupational Exposure Limit-NORWAY | time-weighted average 5 mg/m3, JAN1999 | |
| Occupational Exposure Limit-PERU | time-weighted average 5 mg/m3, JUL2005 | |
| Occupational Exposure Limit-POLAND | MAC(time-weighted average) 1 mg/m3, MAC(short term exposure limit) 8 mg/m3, JAN1999 | |
| Occupational Exposure Limit-RUSSIA | short term exposure limit 1 mg/m3, JUN2003 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 5 mg/m3, carc 3, inhal, skin, JAN2011 | |
| Occupational Exposure Limit-THAILAND | time-weighted average 5 mg/m3, JAN1993 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 5 mg/m3, 2003 | |
| Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 5 mg/m3, JAN1993 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 5 mg/m3 | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 5 mg/m3 | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 5 mg/m3 | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 5 mg/m3 | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CARBARYL-air | 10H time-weighted average 5 mg/m3;min expos during pregnancy | NIOSH* DHHS #95-121,1995 |
| National Occupational Exposure Survey 1983 | Hazard Code 47800; Number of Industries 5; Total Number of Facilities 2381; Number of Occupations 4; Total Number of Employees Exposed 16544; Total Number of Female Employees Exposed 3228 | |
| National Occupational Hazard Survey 1974 | Hazard Code 47800; Number of Industries 5; Total Number of Facilities 678; Number of Occupations 16; Total Number of Employees Exposed 14120 |
Status in Federal Agencies
- Page last reviewed:March 7, 2014
- Page last updated:February 6, 2017
- Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division