Registry of Toxic Effects of Chemical Substances (RTECS)
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Butyronitrile
RTECS #
ET8750000CAS #
109-74-0Updated
August 2009Molecular Weight
69.12Molecular Formula
C4H7NSynonyms
1-CyanopropaneButanenitrile
Butyric acid nitrile
Butyrylonitrile
n-Butanenitrile
n-Butyronitrile
Propyl cyanide
Propylkyanid (Czech)
Skin and Eye Irritation and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| eye /rabbit | 500 mg/24H | mild | 85JCAE -,900,1986 |
| skin /rabbit | 395 mg open irritation test | mild | UCDS** 5/17/1960 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | 200 ppm/6H (6-20D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | FAATDF 20,365,1993 |
| oral/rat | 500 mg/kg (10D pregnant) | Reproductive: Other effects to embryo or fetus | TXAPA9 163,149,2000 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/mouse | lethal concentration (50 percent kill): 249 ppm/1H | Liver: Other changes | CTOXAO 18,991,1981 |
| inhalation/rat | Lowest published lethal concentration: 1000 ppm/4H | AIHAAP 23,95,1962 | |
| inhalation/rat | lethal concentration (10 percent kill): 1848 ppm/1H | Behavioral: Somnolence (general depressed activity) Gastrointestinal: Changes in structure or function of salivary glands | HPV108 -,-,2003 |
| inhalation/rat | lethal concentration (50 percent kill): >1147 ppm/1H | HPV108 -,-,2003 | |
| intraperitoneal/mouse | lethal dose (50 percent kill): 38 mg/kg | Eye: Corneal damage Behavioral: Ataxia Lung, Thorax, or Respiration: Dyspnea | TXAPA9 59,589,1981 |
| intraperitoneal/rat | lethal dose (50 percent kill): 50 mg/kg | Behavioral: Convulsions or effect on seizure threshold Vascular: Regional or general arteriolar or venous dilation Lung, Thorax, or Respiration: Dyspnea | 38MKAJ 2C,4873,1982 |
| intravenous/rabbit | lowest published lethal dose: 980 mg/kg | COREAF 153,895,1911 | |
| oral/cat | lowest published lethal dose: 20 mg/kg | ZAARAM 19,225,1969 | |
| oral/mouse | lethal dose (50 percent kill): 27689 µg/kg | NEZAAQ 39,423,1984 | |
| oral/rabbit | lowest published lethal dose: 50 mg/kg | ZAARAM 19,225,1969 | |
| oral/rat | lethal dose (50 percent kill): 50 mg/kg | Behavioral: Convulsions or effect on seizure threshold Vascular: Regional or general arteriolar or venous dilation Lung, Thorax, or Respiration: Dyspnea | 38MKAJ 2C,4873,1982 |
| oral/rat | lethal dose (50 percent kill): 111 mg/kg | HPV108 -,-,2003 | |
| skin/guinea pig | lowest published lethal dose: 100 mg/kg | KODAK* 21MAY1971 | |
| skin/rabbit | lethal dose (50 percent kill): 500 µL/kg | UCDS** 5/17/1960 | |
| skin/rabbit | lethal dose (50 percent kill): 398 mg/kg | HPV108 -,-,2003 | |
| subcutaneous/frog | lowest published lethal dose: 3100 mg/kg | Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change Behavioral: Tremor Lung, Thorax, or Respiration: Dyspnea | AIPTAK 5,161,1899 |
| subcutaneous/guinea pig | lowest published lethal dose: 100 mg/kg | COREAF 153,895,1911 | |
| subcutaneous/rabbit | lowest published lethal dose: 10 mg/kg | Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change Lung, Thorax, or Respiration: Respiratory depression Lung, Thorax, or Respiration: Respiratory stimulation | AIPTAK 5,161,1899 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| TOXICOLOGY REVIEW | ENTOX* -,370,2005 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO N-BUTYRONITRILE-air | 10H time-weighted average 8 ppm | NIOSH* DHHS #92-100,1992 |
- Page last reviewed:March 7, 2014
- Page last updated:February 6, 2017
- Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division