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Registry of Toxic Effects of Chemical Substances (RTECS)

p-Benzoquinone

RTECS #

DK2625000

CAS #

106-51-4

Updated

September 201

Molecular Weight

108.10

Molecular Formula

C6H4O2

Synonyms

1,4-Benzoquine
1,4-Benzoquinone
1,4-Cyclohexadiene dioxide
1,4-Cyclohexadienedione
1,4-Diossibenzene (Italian)
1,4-Dioxybenzene
1,4-Dioxy-benzol (German)
2,5-Cyclohexadiene-1,4-dione
Benzo-chinon (German)
Chinon (Dutch, German)
Chinone
Cyclohexadienedione
NCI-C55845
p-Benzoquinone (OSHA)
PBQ 2
p-Chinon (German)
p-Quinone
Quinone
Quinone (ACGIH:OSHA)
RCRA waste number U197
Steara PBQ
USAF P-220

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisovary/hamster1 µmol/L/4HMUREAV 661,57,2009
DNA adductbone marrow/human100 µmol/LCRNGDP 12,1181,1991
DNA Damagelymphocyte/mouse4 µmol/LPAACA3 27,81,1986
DNA Damagemammary gland/human1 µmol/L/72HTOXID9 72,204,2003
DNA Damageleukocyte/human10 µmol/L/2HEMMUEG 46,156,2005
DNA Damageovary/hamster0.5 µmol/L/3HMUREAV 661,57,2009
DNA inhibitionlymphocyte/mouse5 µmol/LMOPMA3 28,560,1985
micronucleus testoral/mouse20 mg/kgMUREAV 208,61,1988
micronucleus testembryo/mouse50 µmol/LEMMUEG 19(Suppl 20),21,1992
micronucleus testovary/hamster10 µmol/L/4HMUREAV 661,57,2009
micronucleus testlung/hamster6700 µmol/LEVHPAZ 82,81,1989
morphological transformembryo/mouse400 µg/LCRNGDP 16,477,1995
mutation in mammalian somatic cellslymphocyte/mouse2100 nmol/LMUTAEX 3,193,1988
mutation in microorganisms/Salmonella typhimurium8 mg/plate (+enzymatic activation step)MUREAV 81,11,1981
other mutation test systemsbone marrow/rabbit2 µmol/LAJIMD8 7,485,1985
other mutation test systemslymphocyte/human5 µmol/LCNREA8 45,2471,1985
other mutation test systemslymphocyte/mouse10 µmol/LTOLED5 29,161,1985
other mutation test systemsother cell types/mouse6 µmol/LCBTOE2 2,231,1986
sister chromatid exchangelymphocyte/human5 µmol/LCNREA8 45,2471,1985
specific locus testliver/mouse3.15 µmol/LMUREAV 608,29,2006

Tumorigenic Data and References

Route/OrganismDoseEffectReference
skin/mouse lowest published toxic dose: 800 mg/kg/29W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Skin and Appendages: Tumors		PIATA8 16,309,1940
skin/mouse toxic dose: 6326 mg/kg/43W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Skin and Appendages: Tumors		GANNA2 39,56,1948

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, melanoma Inhibitor Concentration (50 percent kill): 2 mg/L/48HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.FCTOD7 50,2084,2012
In Vitro/jpcInhibitor Concentration Low: 10 µmol/L/24HIn Vitro Toxicity Studies: Other assaysTXCYAC 280,135,2011
intraperitoneal/mouse lethal dose (50 percent kill): 8500 µg/kgPeripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Cyanosis		BCPCA6 12,885,1963
intraperitoneal/rat lethal dose (50 percent kill): 30 mg/kgPHBUA9 3,337,1955
intravenous/rat lethal dose (50 percent kill): 25 mg/kgFEPRA7 8,348,1949
oral/mouse lethal dose (50 percent kill): 25 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Skin and Appendages: Other: Hair		NTIS** OTS0571885
oral/mouse lowest published toxic dose: 20 mg/kg/12HBlood: Changes in bone marrow not included in aboveMUREAV 208,61,1988
oral/rat lethal dose (50 percent kill): 130 mg/kgFEPRA7 8,348,1949
subcutaneous/mammal (species unspecified) lethal dose (50 percent kill): 296 mg/kg85GMAT -,25,1982
subcutaneous/mouse lethal dose (50 percent kill): 93800 µg/kgZGIMAL 2,333,1947
unreported route/rat lethal dose (50 percent kill): 5600 µg/kgBehavioral: Convulsions or effect on seizure thresholdRPTOAN 41,146,1978

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.1 ppmDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 15,255,1977
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 71,1245,1999
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 15,255,1977
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 71,1245,1999
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMEMDT 71,1245,1999
TOXICOLOGY REVIEWMUREAV 566,99,2004
TOXICOLOGY REVIEWTOLED5 140-141,53,2003
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWENTOX* -,597,2005
TOXICOLOGY REVIEWMUREAV 659,31,2008
TOXICOLOGY REVIEWMUTAEX 24,383,2009
TOXICOLOGY REVIEWMUREAV 721,27,2011
TOXICOLOGY REVIEWTXCYAC 286,1,2011
TOXICOLOGY REVIEWMUREAV 751,49,2012
TOXICOLOGY REVIEWMUREAV 751,247,2012

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.1 ppm (0.4 mg/m3)DTLVS* 3,221,1971
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypttime-weighted average 0.1 ppm (0.4 mg/m3), JAN1993
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.1 ppm (0.44 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.1 ppm (0.4 mg/m3);KZW 0.1 ppm (0.4 mg/m3), sen, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.1 ppm (0.45 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.1 ppm (0.4 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.1 ppm (0.45 mg/m3), short term exposure limit 0.3 ppm (1.3 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 0.1 ppm (0.4 mg/m3), VLE 0.3 ppm (1.5 mg/m3), FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 0.1 ppm (0.4 mg/m3), NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 0.1 ppm (0.4 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.1 ppm (0.4 mg/m3);short term exposure limit 0.3 ppm (1 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.1 ppm (0.44 mg/m3), JAN2002
Occupational Exposure Limit-PERUtime-weighted average 0.1 ppm (0.44 mg/m3), JUL2005
Occupational Exposure Limit-POLANDtime-weighted average 0.1 mg/m3, short term exposure limit 0.4 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.05 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 0.1 ppm (0.4 mg/m3);short term exposure limit 0.3 ppm (1.3 mg/m3), JUN2005
Occupational Exposure Limit-SWITZERLANDceiling concentration 0.1 ppm (0.4 mg/m3), sen, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.4 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 5 ppm (15 mg/m3), JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 0.1 ppm (0.4 mg/m3), JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.1 ppm (0.4 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 0.1 ppm (0.4 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 0.1 ppm (0.4 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.1 ppm (0.4 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO QUINONE-air10H time-weighted average 0.1 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 66950; Number of Industries 17; Total Number of Facilities 1228; Number of Occupations 18; Total Number of Employees Exposed 15511; Total Number of Female Employees Exposed 1274
National Occupational Hazard Survey 1974Hazard Code 66950; Number of Industries 3; Total Number of Facilities 145; Number of Occupations 6; Total Number of Employees Exposed 3292

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULEFEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9079;8EHQ-0892-9083
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database

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