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Registry of Toxic Effects of Chemical Substances (RTECS)

Benzene, 1,2,4-trimethyl-

RTECS #

DC3325000

CAS #

95-63-6

Updated

July 2013

Molecular Weight

120.21

Molecular Formula

C9H12

Synonyms

1,2,4-Trimethylbenzene
as-Trimethylbenzene
Asymmetrical trimethylbenzene
Benzene, 1,2,5-trimethyl-
Pseudocumene
Pseudocumol
psi-Cumene

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
sister chromatid exchangeintraperitoneal/mouse900 mg/kgMUREAV 412,299,1998

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): 18000 mg/m3/4HVCVGH* -,175,1990
intraperitoneal/guinea pig lowest published lethal dose: 1.5 mL/kgVCVGH* -,176,1990
intraperitoneal/guinea pig lowest published lethal dose: 1788 mg/kgAMIHBC 9,227,1954
intraperitoneal/rat lethal dose (30 percent kill): 5 mL/kgLung, Thorax, or Respiration: Other changes

Vascular: Regional or general arteriolar or venous dilation		VCVGH* -,176,1990
intraperitoneal/rat lowest published lethal dose: 1752 mg/kg85KYAH 11,1258,1989
oral/mouse lethal dose (50 percent kill): 6900 mg/kgVCVGH* -,175,1990
oral/rat lethal dose (50 percent kill): 5 gm/kg85JCAE -,34,1986

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 20 mg/m3/24H/17W- intermittentKidney, Ureter, and Bladder: Other changes in urine composition

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases		GISAAA 44(5),15,1979
inhalation/rat lowest published toxic concentration: 100 ppm/6H/20D- intermittentBehavioral: Change in motor activity (specific assay)

Behavioral: Analgesia

Behavioral: Alteration of operant conditioning		NRTXDN 22,79,2001
inhalation/rat lowest published toxic concentration: 20 mg/m3/16W- continuousKidney, Ureter, and Bladder: Other changes in urine compositionVCVGH* -,176,1990
oral/rat lowest published toxic dose: 19600 mg/kg/4W- intermittentBrain and Coverings: Recordings from specific areas of CNS

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		VCVGH* -,176,1990
oral/rat lowest published toxic dose: 10 gm/kg/4W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldTIHEEC 1(3),67,1985
oral/rat lowest published toxic dose: 6400 mg/kg/8W- intermittentPeripheral Nerve and Sensation: Recording from afferent nerve

Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		JJATDK 13,123,1993

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUREAV 584,1,2005

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-DENMARKtime-weighted average 20 ppm (100 mg/m3), MAY2011
Occupational Exposure Limit-ECtime-weighted average 100 mg/m3 (20 ppm), JUN2000
Occupational Exposure Limit-FRANCEVLE 20 ppm (100 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 20 ppm (100 mg/m3), 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 100 mg/m3, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 20 ppm (100 mg/m3), NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 25 ppm (120 mg/m3), MAY2012
Occupational Exposure Limit-MEXICOtime-weighted average 25 ppm (125 mg/m3);short term exposure limit 35 ppm (170 mg/m3), 2004
Occupational Exposure Limit-NORWAYtime-weighted average 20 ppm (100 mg/m3), JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 10 mg/m3, short term exposure limit 30 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 25 ppm (120 mg/m3);short term exposure limit 35 ppm (170 mg/m3), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 20 ppm (100 mg/m3), KZG-week 40 ppm (200 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 100 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 25 ppm (125 mg/m3), OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code B0044; Number of Industries 47; Total Number of Facilities 3684; Number of Occupations 42; Total Number of Employees Exposed 65953; Total Number of Female Employees Exposed 9768
National Occupational Hazard Survey 1974Hazard Code B0044; Number of Industries 2; Total Number of Facilities 33; Number of Occupations 13; Total Number of Employees Exposed 3186

Status in Federal Agencies

OrganizationReference
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULEFEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8911
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

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