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Registry of Toxic Effects of Chemical Substances (RTECS)

Benzenamine, 4,4'-methylenebis(2-chloro-

RTECS #

CY1050000

CAS #

101-14-4; 29371-14-0; 51065-07-7; 78642-65-6

Updated

September 201

Molecular Weight

267.17

Molecular Formula

C13H12Cl2N2

Synonyms

3,3'-Dichlor-4,4'-diaminodiphenylmethan (German)
3,3'-Dichloro-4,4'-diaminodifenilmetano (Italian)
3,3'-Dichloro-4,4'-diaminodiphenylmethane
4,4'-Diamino-3,3'-dichlorodiphenylmethane
4,4'-Methylene bis(2-chloroaniline)
4,4'-Methylene bis(2-chloroaniline) (ACGIH)
4,4'-Methylene(bis)-chloroaniline
4,4'-Methylenebis(2-chloroaniline)
4,4'-Methylenebis(o-chloroaniline)
4,4'-Methylenebis-2-chlorobenzenamine
4,4-Metilene-bis-O-cloroanilina (Italian)
Aniline, 4,4'-methylenebis(2-chloro-
Bis amine
Bis(3-chloro-4-aminophenyl)methane
Bis(4-amino-3-chlorophenyl)methane
Bis-amine A
Bisamine S
CL-Mda
Cuamine M
Cuamine MT
Curalin M
Curene 442
Cyanaset
Dacpm
Di(-4-amino-3-chlorophenyl)methane
Di-(4-amino-3-clorofenil)metano (Italian)
Diamet Kh
LD 813
MBOCA
Mboca
Methylene 4,4'-bis(o-chloroaniline)
Methylene-bis-orthochloroaniline
Millionate M
MOCA
p,p'-Methylenebis(alpha-chloroaniline)
p,p'-Methylenebis(o-chloroaniline)
Quodorole
RCRA waste number U158

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damage/Bacillus subtilis1 mg/discPMRSDJ 1,175,1981
DNA Damageoral/mouse600 mg/kgMUREAV 440,1,1999
DNA Damagelung/rat31.2 µmol/L/20HMUREAV 605,94,2006
DNA Damagelung/human3.9 µmol/L/20HMUREAV 605,94,2006
DNA Damageoral/rat570 mg/kgMUREAV 605,94,2006
DNA repair/Escherichia coli500 mg/LPMRSDJ 1,195,1981
gene conversion and mitotic recombination/Saccharomyes cerevisiae100 mg/LPMRSDJ 1,491,1981
micronucleus testintraperitoneal/mouse6400 µg/kgPMRSDJ 1,686,1981
micronucleus testlung/hamster20 µmol/L/6H (-enzymatic activation step)MUTAEX 26,709,2011
micronucleus testlung/hamster78 µmol/L/24H (-enzymatic activation step)MUTAEX 26,709,2011
micronucleus testlung/hamster78 µmol/L/48H (-enzymatic activation step)MUTAEX 26,709,2011
morphological transformfibroblast/mouse10 µg/LJJIND8 67,1303,1981
morphological transformembryo/rat1 mg/LJJIND8 67,1303,1981
morphological transformembryo/hamster2500 µg/LAETODY 1,241,1980
morphological transformkidney/hamster80 µg/LBJCAAI 37,873,1978
mutation in microorganismslymphocyte/mouse5 mg/L (+enzymatic activation step)EMMUEG 12(Suppl 13),103,1988
mutation in microorganisms/Salmonella typhimurium100 µg/plate (+enzymatic activation step)PMRSDJ 1,261,1981
mutation in microorganisms/Salmonella typhimurium33 µg/plate (-enzymatic activation step)ENMUDM 5(Suppl 1),3,1983
mutation in microorganisms/Escherichia coli100 µg/plate (+enzymatic activation step)PMRSDJ 1,387,1981
mutation in microorganisms/Salmonella typhimurium100 mg/L/72H (+enzymatic activation step)MUREAV 558,181,2004
phage inhibition capacity/Escherichia coli1 gm/LPMRSDJ 1,224,1981
sex chromosome loss and nondisjunction/Saccharomyes cerevisiae50 mg/LPMRSDJ 1,468,1981
sister chromatid exchangeovary/hamster500 µg/LENMUDM 7,1,1985
specific locus testoral/Drosophila melanogaster5 mmol/L/48H-continuousMUREAV 211,279,1988
Unscheduled DNA Synthesisliver/rat10 µmol/LMUREAV 204,683,1988
Unscheduled DNA Synthesisliver/hamster10 µmol/LTXAPA9 58,231,1981
Unscheduled DNA Synthesisliver/mouse10 µmol/LTXAPA9 58,231,1981
Unscheduled DNA Synthesisliver/rabbit10 µmol/LCNREA8 43,3120,1983

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/rat toxic dose: 27 gm/kg/79W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors		NATWAY 58,578,1971
oral/rat toxic dose: 27 gm/kg/78W- continuousTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors		TXAPA9 31,159,1975
oral/rat toxic dose: 11 gm/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Skin and Appendages: Tumors		JEPTDQ 2(1),149,1978
oral/rat toxic dose: 8100 mg/kg/77W- continuousTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Endocrine: Tumors		JEPTDQ 2(1),149,1978
oral/rat toxic dose: 16 gm/kg/77W- continuousTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Skin and Appendages: Tumors		JEPTDQ 2(1),149,1978
oral/rat toxic dose: 27 gm/kg/65W- continuousTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Skin and Appendages: Tumors		JEPTDQ 2(1),149,1978
oral/rat toxic dose: 34 gm/kg/80W- continuousTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors		TXAPA9 31,159,1975
oral/rat toxic dose: 21 gm/kg/60W- continuousTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Skin and Appendages: Tumors		TXAPA9 31,159,1975
oral/rat toxic dose: 24 gm/kg/57W- continuousTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors		TXAPA9 31,159,1975
oral/rat lowest published toxic dose: 4050 mg/kg/77W- continuousTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Skin and Appendages: Tumors		JEPTDQ 2(1),149,1978
subcutaneous/rat lowest published toxic dose: 25 gm/kg/89W- continuousTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors		NATWAY 58,578,1971

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 64 mg/kgPMRSDJ 1,682,1981
oral/guinea pig lethal dose (50 percent kill): 400 mg/kgOlfaction: Other olfaction effects

Behavioral: Ataxia

Lung, Thorax, or Respiration: Cyanosis		GISAAA 55(6),86,1990
oral/mouse lowest published toxic dose: 83 mg/kgBlood: Methemoglobinemia- CarboxhemoglobinemiaHPV076 -,-,2005
oral/mouse lethal dose (50 percent kill): 640 mg/kgOlfaction: Other olfaction effects

Behavioral: Ataxia

Lung, Thorax, or Respiration: Cyanosis		GISAAA 55(6),86,1990
oral/rat lethal dose (50 percent kill): 1140 mg/kgHPV076 -,-,2005
oral/rat lethal dose (50 percent kill): 1140 mg/kgOlfaction: Other olfaction effects

Behavioral: Ataxia

Lung, Thorax, or Respiration: Cyanosis		GISAAA 55(6),86,1990
skin/rabbit lethal dose (50 percent kill): >5000 mg/kgHPV076 -,-,2005
subcutaneous/rat lethal dose (50 percent kill): >5 gm/kgNATWAY 58,578,1971
unreported route/rat lowest published lethal dose: 1 gm/kgBehavioral: Muscle weakness

Lung, Thorax, or Respiration: Cyanosis

Kidney, Ureter, and Bladder: Urine volume increased		AIHAAP 32,802,1971

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat lowest published toxic dose: 300 mg/kg/3D- intermittentBehavioral: Food intake (animal)

Endocrine: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		WDZAEK 7,30,1993

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.01 ppm (skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Suspected human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 4,65,1974
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 57,271,1993
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMSUDL 7,246,1987
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 57,271,1993
International Agency for Research on Cancer (IARC)Cancer Review:Group 2AIMEMDT 57,271,1993
TOXICOLOGY REVIEWAIHAAP 39,496,1978
TOXICOLOGY REVIEWTOLED5 134,39,2002
TOXICOLOGY REVIEWMUREAV 543,201,2003
TOXICOLOGY REVIEWFCTOD7 44,1699,2006
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWBCLPT* 96,131,2005
TOXICOLOGY REVIEWMUREAV 654,114,2008
TOXICOLOGY REVIEWHUTOX* -,649,1996
TOXICOLOGY REVIEWMUTAEX 23,271,2008
TOXICOLOGY REVIEWMUREAV 741,32,2012

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.02 ppm (0.22 mg/m3), Carcinogen, JUL2008
Occupational Exposure Limit-AUSTRIATRK-TMW 0.02 mg/m3;KZW 0.08 mg/m3, skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.01 ppm (0.11 mg/m3), Skin, Carcinogen, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.01 ppm (0.11 mg/m3), skin, carc, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.01 ppm (0.11 mg/m3), skin, NOV2011
Occupational Exposure Limit-FRANCEVME 0.02 ppm (0.22 mg/m3), C2 Carcinogen, FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 0.01 ppm (0.11 mg/m3), carc, skin, NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.005 mg/m3, skin, 2A carc, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 0.02 ppm (0.22 mg/m3), skin, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.02 ppm (0.22 mg/m3) (skin), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.005 mg/m3, skin, JAN2002
Occupational Exposure Limit-PERUtime-weighted average 0.01 ppm (0.1 mg/m3), JUL2005
Occupational Exposure Limit-SWEDENGroup B Carcinogen, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.02 mg/m3, carc 2, skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.02 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.005 mg/m3, skin, OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO MOCA-air10H Carcinogen time-weighted average 0.003 mg/m3 (Sk)NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 83341; Number of Industries 1; Total Number of Facilities 4; Number of Occupations 1; Total Number of Employees Exposed 114
National Occupational Hazard Survey 1974Hazard Code 83341; Number of Industries 15; Total Number of Facilities 376; Number of Occupations 13; Total Number of Employees Exposed 2094

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/95/100186/AS)
EPA GENETOX PROGRAM 1988, Positive/dose response: Cell transform.-BALB/c-3T3
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-RLV F344 rat embryo
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE; Mammalian micronucleus
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: MBOCA in urine, 8302
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
On EPA IRIS database
OSHA ANALYTICAL METHOD #24
OSHA ANALYTICAL METHOD #ID-71

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