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Registry of Toxic Effects of Chemical Substances (RTECS)

Aniline, N,N-dimethyl-p-phenylazo-

RTECS #

BX7350000

CAS #

60-11-7

Updated

July 2013

Molecular Weight

225.32

Molecular Formula

C14H15N3

Synonyms

4-(N,N-Dimethylamino)azobenzene
4-(Phenylazo)-N,N-dimethylaniline
4-Dimethylaminoazobenzene (OSHA)
4-Dimethylaminoazobenzol
4-Dimethylaminophenylazobenzene
Atul Fast Yellow R
Azobenzene, p-dimethylamino-
Benzenamine, N,N-dimethyl-4-(phenylazo)- (9CI)
Benzeneazodimethylaniline
Brilliant Fast Oil Yellow
Brilliant Fast Spirit Yellow
Brilliant Fast Yellow
Brilliant Oil Yellow
Butter Yellow
C.I. 11020
C.I. Solvent Yellow 2
Cerasine Yellow GG
DAB
DAB (carcinogen)
Dimethyl Yellow
Dimethyl Yellow Analar
Dimethyl Yellow N,N-dimethylaniline
DMAB
Enial Yellow 2G
Fast Oil Yellow B
Fast Yellow
Fat Yellow
Fat Yellow A
Fat Yellow AD OO
Fat Yellow ES
Fat Yellow ES Extra
Fat Yellow Extra Conc.
Fat Yellow R
Fat Yellow R (8186)
Grasal Brilliant Yellow
Iketon Yellow Extra
Jaune de beurre (French)
Methyl Yellow
N,N-Dimethyl-4-(phenylazo)benzamine
N,N-Dimethyl-4-(phenylazo)benzenamine
N,N-Dimethyl-4-aminoazobenzene
N,N-Dimethyl-p-aminoazobenzene
N,N-Dimethyl-p-azoaniline
N,N-Dimethyl-p-phenylazoaniline
Oil Yellow 20
Oil Yellow 2625
Oil Yellow 2G
Oil Yellow 7463
Oil Yellow BB
Oil Yellow D
Oil Yellow DN
Oil Yellow FF
Oil Yellow FN
Oil Yellow G
Oil Yellow G-2
Oil Yellow GG
Oil Yellow GR
Oil Yellow II
Oil Yellow N
Oil Yellow PEL
Oil Yellow S
Oleal Yellow 2G
Organol Yellow ADM
Orient Oil Yellow GG
P.D.A.B.
p-Dimethylaminoazobenzen (Czech)
p-Dimethylaminoazobenzene
p-Dimethylamino-azobenzol (German)
Petrol Yellow WT
RCRA waste number U093
Resinol Yellow GR
Resoform Yellow GGA
Silotras Yellow T2G
Somalia Yellow A
Stear Yellow JB
Sudan GG
Sudan Yellow
Sudan Yellow GG
Sudan Yellow GGA
Toyo Oil Yellow G
USAF EK-338
Waxoline Yellow AD
Waxoline Yellow ADS
Yellow G soluble in grease
Zlut maselna (Czech)
Zlut rozpoustedlova 2 (Czech)

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
body fluid assaySalmonella typhimurium/rat600 mg/kgNATUAS 249,850,1974
Cytogenetic Analysisoral/rat756 mg/kg/3WJNCIAM 54,1245,1975
Cytogenetic Analysisoral/mouse4950 mg/kg/30D- intermittentMUREAV 587,1,2005
Cytogenetic Analysisoral/mouse4950 mg/kg/30D-continuousFCTOD7 46,1474,2008
DNA adductoral/rat300 mg/kgCNREA8 36,4647,1976
DNA adductintraperitoneal/rat150 mg/kgNATUAS 213,1206,1967
DNA adductintraperitoneal/mouse120 mg/kgCNREA8 40,2493,1980
DNA adductskin/mouse192 µmol/kgCRNGDP 5,231,1984
DNA Damageintraperitoneal/mouse200 mg/kgMUREAV 493,39,2001
DNA Damageoral/mouse500 mg/kgMUREAV 493,39,2001
DNA inhibitionintraperitoneal/mouse20 gm/kgARGEAR 51,605,1981
DNA inhibitionoral/mouse100 mg/kgMUREAV 46,305,1977
DNA inhibitionHeLa cell/human100 µmol/LMUREAV 92,427,1982
DNA repair/Escherichia coli80 mg/LMUREAV 119,135,1983
DNA repair/Saccharomyes cerevisiae600 mg/LPMRSDJ 1,502,1981
gene conversion and mitotic recombination/Saccharomyes cerevisiae5 mg/LPMRSDJ 1,491,1981
gene conversion and mitotic recombinationoral/Drosophila melanogaster2.0 mmol/L/48HMUTAEX 16,385,2001
host-mediated assaySalmonella typhimurium/mouse255 mg/kg/3HMUREAV 45,291,1977
micronucleus testintraperitoneal/mouse6400 µg/kgPMRSDJ 1,686,1981
micronucleus testoral/mouse1155 mg/kg/7D-continuousFCTOD7 46,1474,2008
micronucleus testoral/rat150 mg/kg/2D- intermittentMUREAV 698,24,2010
micronucleus testoral/mouse9900 mg/kg/60D- intermittentMUREAV 587,1,2005
micronucleus testintraperitoneal/rat71 mg/kgMUREAV 583,133,2005
micronucleus testoral/rat120 mg/kgMUREAV 583,133,2005
morphological transformembryo/rat12 mg/LJJIND8 67,1303,1981
morphological transformembryo/mouse89 µmol/LMUREAV 152,113,1985
morphological transformother cell types/non-mammalian species250 µg/LAOHYA3 20,297,1977
morphological transformfibroblast/mouse1 mg/L/21D (-enzymatic activation step)EMMUEG 35,300,2000
morphological transformintraperitoneal/hamster500 mg/kgARPAAQ 95,380,1973
morphological transformembryo/hamster50 µg/LJJIND8 67,1303,1981
morphological transformkidney/hamster25 mg/LPMRSDJ 1,638,1981
mutation in mammalian somatic cellslymphocyte/mouse89 µmol/LMUREAV 110,147,1983
mutation in microorganismslymphocyte/mouse6250 µg/L (+enzymatic activation step)EMMUEG 12(Suppl 13),103,1988
mutation in microorganisms/Salmonella typhimurium5 mg/plate (+enzymatic activation step)AEMIDF 42,641,1981
mutation in microorganisms/Salmonella typhimurium33 µg/plate (-enzymatic activation step)ENMUDM 9(Suppl 9),1,1987
mutation in microorganisms/Escherichia coli200 mg/L (+enzymatic activation step)PMRSDJ 1,396,1981
other mutation test systemsintraperitoneal/mouse100 mg/kgMUREAV 747,164,2012
sex chromosome loss and nondisjunction/Saccharomyes cerevisiae50 mg/LPMRSDJ 1,468,1981
sister chromatid exchangeintraperitoneal/mouse29 mg/kgMUREAV 108,225,1983
specific locus testother cell types/human50 mg/L/3H (+enzymatic activation step)MUTAEX 24,35,2009
sperm morphologyoral/mouse9900 mg/kg/60D-continuousFCTOD7 46,1474,2008
sperm morphologyintraperitoneal/mouse3 gm/kg/5D- intermittentPMRSDJ 1,712,1981
Unscheduled DNA Synthesisliver/mouse1 µmol/LGANNA2 72,930,1981
Unscheduled DNA Synthesisliver/hamster1 µmol/LENMUDM 5,1,1983
Unscheduled DNA SynthesisHeLa cell/human10 nmol/LCNREA8 38,2621,1978
Unscheduled DNA Synthesisfibroblast/human4 mg/LPMRSDJ 1,528,1981
Unscheduled DNA Synthesisliver/rat1 µmol/LCNREA8 46,1654,1986
Unscheduled DNA Synthesisliver/rat1 µmol/LJJCREP 78,505,1987

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse 3 gm/kg (5D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)PMRSDJ 1,712,1981
subcutaneous/mouse 200 mg/kg (10D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemOFAJAE 36,195,1960

Tumorigenic Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lowest published toxic dose: 3830 µg/kgTumorigenic: Neoplastic by RTECS criteria

Liver: Tumors		CNREA8 44,2540,1984
intraperitoneal/mouse toxic dose: 11 mg/kgTumorigenic: Neoplastic by RTECS criteria

Liver: Tumors		CNREA8 44,2540,1984
multiple/mouse lowest published toxic dose: 400 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Tumorigenic: Tumors at site of application		CNREA8 1,397,1941
oral/Dog lowest published toxic dose: 9600 mg/kg/69W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors		JNCIAM 13,1497,1953
oral/hamster lowest published toxic dose: 9600 mg/kg/42W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Change in gall bladder structure or function

Blood: Other hemolysis with or without anemia		ARPAAQ 71,566,1961
oral/mouse lowest published toxic dose: 9900 mg/kg/60D- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors		FCTOD7 46,1474,2008
oral/rat lowest published toxic dose: 3.24 gm/kg/90D- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors		FCTOD7 48,3281,2010
oral/rat toxic dose: 800 mg/kg/64D- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors		ZEKBAI 61,327,1956
oral/rat lowest published toxic dose: 5426 mg/kg/17W- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors		CBINA8 53,107,1985
oral/rat toxic dose: 2600 mg/kg/13W- continuousTumorigenic: Neoplastic by RTECS criteria

Liver: Tumors		CNREA8 17,387,1957
oral/rat toxic dose: 13 gm/kg/53W- continuousTumorigenic: Neoplastic by RTECS criteria

Liver: Tumors		MEXPAG 4,1,1961
oral/rat toxic dose: 1920 mg/kg/14W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors		CNREA8 5,235,1945
oral/rat toxic dose: 1800 mg/kg/14W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors		CNREA8 8,141,1948
oral/rat toxic dose: 2331 mg/kg/7W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors		KTUNAA 32,229,1979
oral/rat toxic dose: 17200 mg/kg/17W- continuousTumorigenic: Neoplastic by RTECS criteria

Liver: Tumors		ARPAAQ 81,162,1966
oral/rat toxic dose: 8316 mg/kg/33W- continuousTumorigenic: Neoplastic by RTECS criteria

Liver: Tumors		JPBAA7 59,1,1947
oral/rat toxic dose: 3990 mg/kg/19W- continuousTumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Consolidation

Liver: Tumors		GANNA2 63,131,1972
skin/rat lowest published toxic dose: 1440 mg/kg/90W- intermittentTumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors		CNREA8 26,2406,1966
subcutaneous/mouse lowest published toxic dose: 4000 mg/kg (15-21D pregnant)Tumorigenic: Carcinogenic by RTECS criteria

Reproductive: Tumorigenic effects: Transplacental tumorigenesis

Lung, Thorax, or Respiration: Tumors		BEXBAN 78,1402,1974

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 230 mg/kgLung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Cyanosis		CNREA8 34,2274,1974
intraperitoneal/mouse lethal dose (50 percent kill): 230 mg/kgENTOX* -,356,2005
intraperitoneal/mouse lowest published lethal dose: 230 mg/kgMUREAV 747,164,2012
intraperitoneal/rat lethal dose (50 percent kill): 230 mg/kgLung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Cyanosis		CNREA8 34,2274,1974
intraperitoneal/rat lethal dose (50 percent kill): 230 mg/kgENTOX* -,356,2005
oral/mouse lethal dose (50 percent kill): 300 mg/kgENTOX* -,53,2005
oral/rat lethal dose (50 percent kill): 200 mg/kgENTOX* -,53,2005

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 20000 mg/kg/40D- continuousLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects		BJCAAI 86,630,2002
oral/mouse lowest published toxic dose: 9900 mg/kg/60D- intermittentLiver: Tumors

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)		MUREAV 587,1,2005
oral/mouse lowest published toxic dose: 1155 mg/kg/7D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases		MUREAV 587,1,2005
oral/mouse lowest published toxic dose: 1155 mg/kg/7D- continuousLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Changes in spleen		FCTOD7 46,1474,2008

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 8,125,1975
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 8,125,1975
International Agency for Research on Cancer (IARC)Cancer Review:Group 2BIMSUDL 7,56,1987
TOXICOLOGY REVIEWALLVAR 50,77,1962
TOXICOLOGY REVIEWBJCAAI 6,270,1952
TOXICOLOGY REVIEWADCSAJ 13,271,1970
TOXICOLOGY REVIEWJONUAI 44,345,1951
TOXICOLOGY REVIEWBLFSBY 24,129,1983
TOXICOLOGY REVIEWMUREAV 567,347,2004
TOXICOLOGY REVIEWMUREAV 578,88,2005
TOXICOLOGY REVIEWENTOX* -,356,2005
TOXICOLOGY REVIEWMUREAV 627,10,2007
TOXICOLOGY REVIEWENTOX* -,53,2005
TOXICOLOGY REVIEWENTOX* -,104,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWMUREAV 654,114,2008
TOXICOLOGY REVIEWMUREAV 681,51,2009
TOXICOLOGY REVIEWMUTAEX 26,223,2011
TOXICOLOGY REVIEWMUREAV 733,4,2012

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-JAPAN2B carc, MAY2012
Occupational Exposure Limit-SWEDENGroup A Carcinogen, JUN2005
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)see Code of Federal Regulations (CFR) 29,1926.1115CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA)-cancer suspect agentCFRGBR 29,1910.1015,1987

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 4-DIMETHYLAMINOAZOBENZENE-airCarcinogen use 29 Code of Federal Regulations (CFR) 1910.1015NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 26175; Number of Industries 2; Total Number of Facilities 56; Number of Occupations 2; Total Number of Employees Exposed 1453; Total Number of Female Employees Exposed 996
National Occupational Hazard Survey 1974Hazard Code 26175; Number of Industries 2; Total Number of Facilities 29; Number of Occupations 2; Total Number of Employees Exposed 42

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Inconclusive: E coli polA without S9
EPA GENETOX PROGRAM 1988, Inconclusive: In vitro UDS-human fibroblast
EPA GENETOX PROGRAM 1988, Inconclusive: SHE-clonal assay; B subtilis rec assay
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-BALB/c-3T3; E coli polA with S9
EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouse; S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Positive: Body fluid assay; Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-RLV F344 rat embryo
EPA GENETOX PROGRAM 1988, Positive: Mammalian micronucleus; Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 10th Report on Carcinogens,2002:Reasonably anticipated to be a human carcinogen
On EPA IRIS database

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