Registry of Toxic Effects of Chemical Substances (RTECS)

Acrolein

RTECS #

AS1050000

CAS #

107-02-8; 25314-61-8

Updated

December 2013

Molecular Weight

56.07

Molecular Formula

C₃H₄O

Synonyms

2-Propenal
Acraldehyde
Acraldehydeacroleina (Italian)
Acrolein (ACGIH:OSHA)
Acroleina (Italian)
Acroleine (Dutch, French)
Acrylaldehyd (German)
Acrylaldehyde
Acrylic aldehyde
Akrolein (Czech)
Akroleina (Polish)
Aldehyde acrylique (French)
Aldeide acrilica (Italian)
Allyl aldehyde
Aqualin
Aqualine
Biocide
Crolean
Ethylene aldehyde
Magnacide
Magnacide B
Magnacide H
NSC 8819
Prop-2-en-1-al
RCRA waste number P003
Slimicide
trans-Acrolein

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /human	500 ppb/12M		IAPWAR 4,79,1961
eye /rabbit	1 mg	severe	UCDS** 6/18/1971
eye /rabbit	50 µg/24H	severe	85JCAE -,268,1986
skin /human	1%		VCVGK* -,386,1994
skin /rabbit	5 mg open irritation test	severe	UCDS** 6/18/1971
skin /rabbit	2 mg/24H	severe	85JCAE -,268,1986

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
DNA adduct	/Escherichia coli	286 nmol/L	ARTODN 46,277,1980
DNA adduct	fibroblast/human	100 µmol/L	CRNGDP 12,1483,1991
DNA adduct	lymphocyte/mammal (species unspecified)	58 gm/L/3H	CNREA8 44,990,1984
DNA Damage	other cell types/rat	30 mmol/L	ARTODN 58,67,1985
DNA Damage	other cell types/human	30 µmol/L	CNREA8 48,1717,1988
DNA Damage	lung/human	0.15 pmol/well/1H	TOLED5 132,27,2002
DNA Damage	lung/hamster	20 nmol/L/18H	TOLED5 148,65,2004
DNA inhibition	intraperitoneal/rat	500 µg/kg	BICMBE 53,243,1971
DNA inhibition	lymphocyte/mammal (species unspecified)	80 µmol/L	FEBLAL 30,286,1973
mutation in mammalian somatic cells	fibroblast/human	200 nmol/L	MUREAV 209,17,1988
mutation in mammalian somatic cells	lung/hamster	500 nmol/L	CRNGDP 11,497,1990
mutation in microorganisms	/Escherichia coli	320 nmol/plate	MUREAV 516,81,2002
mutation in microorganisms	/Salmonella typhimurium	50 µg/plate (+enzymatic activation step)	ENMUDM 5(Suppl 1),3,1983
mutation in microorganisms	/Salmonella typhimurium	50 µg/plate (-enzymatic activation step)	NTPTB* JAN1982
other mutation test systems	intraperitoneal/rat	500 µg/kg	BICMBE 53,243,1971
sex chromosome loss and nondisjunction	parenteral/Drosophila melanogaster	3 mmol/L	MUREAV 260,247,1991
sister chromatid exchange	lymphocyte/human	5 µmol/L	CNREA8 46,203,1986
sister chromatid exchange	ovary/hamster	10 µmol/L	CGCGBR 26,108,1980
sister chromatid exchange	unreported route/hamster	1.5 mg/kg	VCVGK* -,385,1994
specific locus test	oral/Drosophila melanogaster	5 mmol/L	MUREAV 260,247,1991
specific locus test	other cell types/mouse	10 µmol/L/4H (-enzymatic activation step)	MUREAV 726,98,2011

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
intravenous/rabbit	6 mg/kg (9D pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)	ARZNAD 30,2080,1980
oral/rat	840 mg/kg (multigeneration)	Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	FAATDF 19,228,1992

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
In Vitro/Human, lung tumor	Inhibitor Concentration Low: 0.01 nmol/L/4H	In Vitro Toxicity Studies: Other assays	FCTOD7 49,2157,2011
In Vitro/Human, lung tumor	Inhibitor Concentration Low: 30 nmol/L/30M	In Vitro Toxicity Studies: Other assays	FCTOD7 49,2157,2011
In Vitro/Human, lung tumor	Inhibitor Concentration Low: 30 nmol/L/10M	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphokinase	FCTOD7 49,2157,2011
In Vitro/Human, neuroblastoma	Inhibitor Concentration Low: 440 µmol/L/4M	In Vitro Toxicity Studies: Membrane currents	TXAPA9 245,191,2010
In Vitro/Mouse, macrophage	Inhibitor Concentration Low: 1 µmol/L/24H	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Peptidases	TXAPA9 245,76,2010
In Vitro/Mouse, macrophage	Inhibitor Concentration Low: 10 µmol/L/30M	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphokinase	TXAPA9 245,76,2010
In Vitro/Mouse, macrophage	Inhibitor Concentration Low: 10 µmol/L/4H	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Peptidases	TXAPA9 245,76,2010
inhalation/cat	Lowest published lethal concentration: 1570 mg/m³/2H		APTOA6 6,299,1950
inhalation/cat	lowest published toxic concentration: 250 mg/m³	Eye: Lacrimation Behavioral: General anesthetic Gastrointestinal: Changes in structure or function of salivary glands	VCVGK* -,383,1984
inhalation/cat	lowest published toxic concentration: 200 mg/m³	Lung, Thorax, or Respiration: Other changes	VCVGK* -,383,1984
inhalation/cat	Lowest published lethal concentration: 1500 mg/m³/2H	Lung, Thorax, or Respiration: Acute pulmonary edema Liver: Multiple effects Kidney, Ureter, and Bladder: Other changes	VCVGK* -,383,1984
inhalation/child	lowest published toxic concentration: 300 ppb/2H	Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Lung, Thorax, or Respiration: Respiratory obstruction Lung, Thorax, or Respiration: Other changes	NPMDAD 8,2469,1979
inhalation/guinea pig	Lowest published lethal concentration: 24 mg/m³/6H	Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Lung, Thorax, or Respiration: Emphysema Lung, Thorax, or Respiration: Acute pulmonary edema	BMJOAE 2,913,1956
inhalation/guinea pig	lethal concentration (50 percent kill): 10.5 ppm/6H	Brain and Coverings: Other degenerative changes Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage) Lung, Thorax, or Respiration: Respiratory depression	VCVGK* -,383,1984
inhalation/hamster	Lowest published lethal concentration: 1000 ppm/10M	Eye: Lacrimation Lung, Thorax, or Respiration: Acute pulmonary edema Gastrointestinal: Changes in structure or function of salivary glands	SAIGBL 19,367,1977
inhalation/hamster	lethal concentration (50 percent kill): 25.4 ppm/4H		VCVGK* -,383,1984
inhalation/human	lowest published toxic concentration: 7 mg/m³	Eye: Lacrimation Lung, Thorax, or Respiration: Respiratory depression	VCVGK* -,384,1984
inhalation/human	lowest published toxic concentration: 2 mg/m³/2M	Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Cough	VCVGK* -,384,1984
inhalation/human	lowest published toxic concentration: 0.6 mg/m³/5M	Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Cough	VCVGK* -,384,1984
inhalation/human	lowest published toxic concentration: 0.8 ppm	Lung, Thorax, or Respiration: Dyspnea	VCVGK* -,384,1984
inhalation/human	lowest published toxic concentration: 0.3 ppm	Lung, Thorax, or Respiration: Cough	VCVGK* -,384,1984
inhalation/human	lowest published toxic concentration: 0.14 ppm/2M	Eye: Conjunctiva irritation	VCVGK* -,384,1984
inhalation/human	Lowest published lethal concentration: 350 mg/m³/10M		VCVGK* -,384,1984
inhalation/human	Lowest published lethal concentration: 5500 ppb		34ZIAG -,73,1969
inhalation/human	Lowest published lethal concentration: 153 ppm/10M		NTIS** PB214-270
inhalation/man	lowest published toxic concentration: 1 ppm	Eye: Lacrimation	BMJOAE 2,913,1956
inhalation/mouse	lethal concentration (50 percent kill): 66 ppm/6H		IAANBS 26,281,1970
inhalation/mouse	lethal concentration (50 percent kill): 875 ppm/1M	Brain and Coverings: Other degenerative changes Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage) Lung, Thorax, or Respiration: Respiratory depression	VCVGK* -,383,1984
inhalation/mouse	lethal concentration (50 percent kill): 175 ppm/10M	Brain and Coverings: Other degenerative changes Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage) Lung, Thorax, or Respiration: Respiratory depression	VCVGK* -,383,1984
inhalation/mouse	lethal concentration (50 percent kill): 152 mg/m³/6H	Brain and Coverings: Other degenerative changes Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage) Lung, Thorax, or Respiration: Respiratory depression	VCVGK* -,383,1984
inhalation/mouse	Lowest published lethal concentration: 200 mg/m³		VCVGK* -,383,1984
inhalation/mouse	Lowest published lethal concentration: 650 mg/m³	Lung, Thorax, or Respiration: Other changes	VCVGK* -,383,1984
inhalation/mouse	lowest published toxic concentration: 1.7 ppm/10M	Lung, Thorax, or Respiration: Respiratory depression	VCVGK* -,383,1984
inhalation/mouse	lowest published toxic concentration: 1.1 ppm	Olfaction: Other olfaction effects	TOXID9 66,98,2002
inhalation/mouse	lowest published toxic concentration: 5 ppm/6H	Blood: Change in clotting factors Blood: Other changes	TXAPA9 248,100,2010
inhalation/rabbit	lethal concentration (50 percent kill): 10.5 ppm/6H		VCVGK* -,383,1984
inhalation/rabbit	Lowest published lethal concentration: 24 mg/m³/6H	Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Lung, Thorax, or Respiration: Emphysema Lung, Thorax, or Respiration: Acute pulmonary edema	BMJOAE 2,913,1956
inhalation/rat	lethal concentration (50 percent kill): 18 mg/m³/4H		CUTOEX 1,47,1993
inhalation/rat	lethal concentration (50 percent kill): 131 ppm/30M	Brain and Coverings: Other degenerative changes Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage) Lung, Thorax, or Respiration: Respiratory depression	VCVGK* -,383,1984
inhalation/rat	lethal concentration (50 percent kill): 8 ppm/4H	Brain and Coverings: Other degenerative changes Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage) Lung, Thorax, or Respiration: Respiratory depression	VCVGK* -,383,1984
inhalation/rat	lowest published toxic concentration: 23 ppm	Lung, Thorax, or Respiration: Respiratory depression	VCVGK* -,383,1984
inhalation/rat	lowest published toxic concentration: 2.5 ppm/4H	Vascular: Other changes	VCVGK* -,383,1984
intraperitoneal/mouse	lethal dose (50 percent kill): 9008 µg/kg		NCISP* JAN1986
intraperitoneal/rat	lethal dose (50 percent kill): 4 mg/kg		TXAPA9 71,84,1983
intravenous/cat	lowest published lethal dose: 15 mg/kg	Blood: Other changes	APTOA6 8,275,1952
intravenous/rat	lowest published toxic dose: 3 mg/kg	Gastrointestinal: Other changes Blood: Changes in other cell count (unspecified)	VCVGK* -,384,1984
intravenous/rat	lowest published toxic dose: 0.5 mg/kg	Vascular: BP lowering not characterized in autonomic section	VCVGK* -,384,1984
intravenous/rat	lowest published toxic dose: 0.05 mg/kg	Vascular: BP elevation not characterized in autonomic section	VCVGK* -,384,1984
oral/human	lowest published lethal dose: 140 mg/kg		VCVGK* -,384,1984
oral/mammal (species unspecified)	lowest published lethal dose: 10 mg/kg		AJHYA2 29,32,1939
oral/mouse	lethal dose (50 percent kill): 28 mg/kg		VCVGK* -,383,1984
oral/mouse	lethal dose (50 percent kill): 13900 µg/kg	Behavioral: Somnolence (general depressed activity) Skin and Appendages: Other: Hair Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NTIS** OTS0533812
oral/mouse	lowest published toxic dose: 5 mg/kg	Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes Biochemical: Metabolism (intermediary): Lipids including transport	TOXID9 -,169,2008
oral/mouse	lowest published toxic dose: 5 mg/kg	Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Metabolism (intermediary): Lipids including transport Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation	TXAPA9 243,1,2010
oral/mouse	lowest published toxic dose: 5 mg/kg	Behavioral: Tremor Gastrointestinal: Changes in structure or function of salivary glands	TOXID9 90,105,2006
oral/mouse	lowest published lethal dose: 8 mg/kg	Behavioral: Tremor Gastrointestinal: Changes in structure or function of salivary glands	TOXID9 90,105,2006
oral/mouse	lowest published toxic dose: 5 mg/kg	Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)	TOXID9 44,377,2005
oral/mouse	lowest published toxic dose: 5 mg/kg	Blood: Change in clotting factors Blood: Other changes	TXAPA9 248,100,2010
oral/rabbit	lethal dose (50 percent kill): 7 mg/kg		ENTOX* -,40,2005
oral/rat	lethal dose (50 percent kill): 26 mg/kg		GISAAA 58(10),4,1993
skin/rabbit	lethal dose (50 percent kill): 160 mg/kg		ENTOX* -,40,2005
subcutaneous/guinea pig	lowest published lethal dose: 178 µg/kg	Behavioral: Convulsions or effect on seizure threshold Cardiac: Other changes Lung, Thorax, or Respiration: Dyspnea	AEXPBL 43,351,1900
subcutaneous/mouse	lethal dose (50 percent kill): 30 mg/kg	Behavioral: General anesthetic Liver: Fatty liver degeneration	APTOA6 6,299,1950
subcutaneous/mouse	lowest published lethal dose: 400 mg/kg	Behavioral: Excitement Vascular: Shock	VCVGK* -,383,1984
subcutaneous/rabbit	lethal dose (50 percent kill): 164 mg/kg		VCVGK* -,383,1984
subcutaneous/rabbit	lowest published lethal dose: 250 mg/kg	Lung, Thorax, or Respiration: Dyspnea	AEXPBL 43,351,1900
subcutaneous/rat	lethal dose (50 percent kill): 50 mg/kg	Behavioral: General anesthetic Liver: Fatty liver degeneration	APTOA6 6,299,1950
unreported route/mammal (species unspecified)	lethal dose (50 percent kill): 45 mg/kg		30ZDA9 -,111,1971

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/Dog	lowest published toxic concentration: 3700 ppb/8H/6W- intermittent	Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi	TXAPA9 17,726,1970
inhalation/hamster	lowest published toxic concentration: 4900 ppb/6H/13W- intermittent	Olfaction: Other olfaction effects Lung, Thorax, or Respiration: Other changes Lung, Thorax, or Respiration: Changes in lung weight	TXCYAC 9,47,1978
inhalation/hamster	lowest published toxic concentration: 4 ppm/7H/52W- intermittent	Brain and Coverings: Changes in brain weight Lung, Thorax, or Respiration: Changes in lung weight Liver: Changes in liver weight	JTEHD6 3,379,1977
inhalation/hamster	lowest published toxic concentration: 4.9 ppm/13W- intermittent	Blood: Changes in other cell count (unspecified) Blood: Changes in erythrocyte (RBC) count	VCVGK* -,385,1994
inhalation/monkey	lowest published toxic concentration: 3700 ppb/8H/6W- intermittent	Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	TXAPA9 17,726,1970
inhalation/mouse	lowest published toxic concentration: 1 ppm/3D- intermittent	Cardiac: Changes in coronary arteries	TOXID9 -,137,2009
inhalation/mouse	lowest published toxic concentration: 1 ppm/6H/4D- intermittent	Blood: Change in clotting factors Blood: Other changes	TXAPA9 248,100,2010
inhalation/mouse	lowest published toxic concentration: 6 ppm/6H/2W- intermittent	Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion Nutritional and Gross Metabolic: Weight loss or decreased weight gain	VCVGK* -,384,1994
inhalation/mouse	lowest published toxic concentration: 25 ppm/6H/2W- intermittent	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	VCVGK* -,384,1994
inhalation/rabbit	lowest published toxic concentration: 4900 ppb/6H/13W- intermittent	Olfaction: Other olfaction effects Lung, Thorax, or Respiration: Other changes Lung, Thorax, or Respiration: Changes in lung weight	TXCYAC 9,47,1978
inhalation/rat	lowest published toxic concentration: 3 ppm/2W- intermittent	Lung, Thorax, or Respiration: Other changes	TXCYAC 260,112,2009
inhalation/rat	lowest published toxic concentration: 1.52 ppm/61D- continuous	Lung, Thorax, or Respiration: Other changes	VCVGK* -,384,1994
inhalation/rat	lowest published toxic concentration: 0.51 ppm/61D- continuous	Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi	VCVGK* -,384,1994
inhalation/rat	lowest published toxic concentration: 0.55 ppm/10D- continuous	Lung, Thorax, or Respiration: Cough Immunological Including Allergic: Decreased immune response	VCVGK* -,384,1994
inhalation/rat	lowest published toxic concentration: 4 ppm/6H/62D- intermittent	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	VCVGK* -,385,1994
inhalation/rat	lowest published toxic concentration: 1.4 ppm/6H/62D- intermittent	Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Lung, Thorax, or Respiration: Other changes	VCVGK* -,385,1994
inhalation/rat	lowest published toxic concentration: 1.52 mg/m³/60D- continuous	Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	VCVGK* -,385,1994
inhalation/rat	lowest published toxic concentration: 0.51 mg/m³/60D- continuous	Behavioral: Alteration of classical conditioning Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Biochemical: Metabolism (intermediary): Porphyrin including bile pigments	VCVGK* -,385,1994
inhalation/rat	lowest published toxic concentration: 0.15 mg/m³/60D- continuous	Blood: Changes in leukocyte (WBC) count	VCVGK* -,385,1994
inhalation/rat	lowest published toxic concentration: 4 ppm/6H/62D- intermittent	Lung, Thorax, or Respiration: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	TXCYAC 34,139,1985
inhalation/rat	lowest published toxic concentration: 4900 ppb/6H/13W- intermittent	Olfaction: Other olfaction effects Endocrine: Changes in adrenal weight Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	TXCYAC 9,47,1978
inhalation/rat	lowest published toxic concentration: 510 µg/m³/24H/9W- continuous	Kidney, Ureter, and Bladder: Other changes in urine composition Blood: Changes in leukocyte (WBC) count Nutritional and Gross Metabolic: Weight loss or decreased weight gain	GISAAA 31(1),9,1966
inhalation/rat	lowest published toxic concentration: 3 ppm/6H/3W- intermittent	Olfaction: Other olfaction effects Endocrine: Changes in spleen weight	TOLED5 39,189,1987
intratracheal/chicken	lowest published toxic dose: 200 ppm/5M/3D- intermittent	Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi	VCVGK* -,385,1994
oral/mouse	lowest published toxic dose: 162.5 mg/kg/90D- intermittent	Gastrointestinal: Gastritis	TXCYAC 253,79,2008
oral/mouse	lowest published toxic dose: 650 mg/kg/90D- intermittent	Gastrointestinal: Gastritis Liver: Changes in liver weight	TXCYAC 253,79,2008
oral/mouse	lowest published toxic dose: 100 mg/kg/7D- intermittent	Gastrointestinal: Gastritis Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	TXCYAC 253,79,2008
oral/rat	lowest published toxic dose: 113 mg/kg/45D- intermittent	Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes	IJEBA6 35,1373,1997
oral/rat	lowest published toxic dose: 91 mg/kg/26W- intermittent	Liver: Liver function tests impaired Kidney, Ureter, and Bladder: Other changes	VCVGK* -,385,1994
oral/rat	lowest published toxic dose: 325 mg/kg/90D- intermittent	Liver: Changes in liver weight	TXCYAC 253,79,2008
oral/rat	lowest published toxic dose: 450 mg/kg/63D- intermittent	Gastrointestinal: Gastritis Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	TXCYAC 253,79,2008

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-ceiling concentration 0.1 ppm (skin)	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Not classifiable as a human carcinogen	DTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Inadequate Evidence	IMEMDT 19,479,1979
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Inadequate Evidence	IMEMDT 36,133,1985
International Agency for Research on Cancer (IARC)	Cancer Review:Human Inadequate Evidence	IMEMDT 36,133,1985
International Agency for Research on Cancer (IARC)	Cancer Review:Human Inadequate Evidence	IMEMDT 63,337,1995
International Agency for Research on Cancer (IARC)	Cancer Review:Group 3	IMSUDL 7,78,1987
International Agency for Research on Cancer (IARC)	Cancer Review:Group 3	IMEMDT 63,339,1995
TOXICOLOGY REVIEW		EVHPAZ 11,163,1975
TOXICOLOGY REVIEW		CMTVAS 10(3),49,1973
TOXICOLOGY REVIEW		MUREAV 47,115,1978
TOXICOLOGY REVIEW		MUREAV 544,115,2003
TOXICOLOGY REVIEW		MUREAV 567,347,2004
TOXICOLOGY REVIEW		ENTOX* -,40,2005
TOXICOLOGY REVIEW		DIMON* 46,551,2000
TOXICOLOGY REVIEW		MUREAV 584,1,2005
TOXICOLOGY REVIEW		MUREAV 531,1,2003
TOXICOLOGY REVIEW		MUTAEX 19,169,2004
TOXICOLOGY REVIEW		REPTED 23,428,2007
TOXICOLOGY REVIEW		MUREAV 659,56,2008
TOXICOLOGY REVIEW		HUTOX* -,649,1996
TOXICOLOGY REVIEW		MUREAV 674,62,2009
TOXICOLOGY REVIEW		MUREAV 674,85,2009
TOXICOLOGY REVIEW		MUREAV 636,144,2007
TOXICOLOGY REVIEW		BPRCR* 23,391,2009
TOXICOLOGY REVIEW		MUTAEX 22,161,2007
TOXICOLOGY REVIEW		MUREAV 690,3,2010
TOXICOLOGY REVIEW		PRESR* 7,123,2006
TOXICOLOGY REVIEW		MUREAV 711,13,2011
TOXICOLOGY REVIEW		TIHEEC 24,447,2008
TOXICOLOGY REVIEW		MUREAV 722,147,2011
TOXICOLOGY REVIEW		FCTOD7 49,2921,2011
TOXICOLOGY REVIEW		EMMUEG 53,645,2012

Standards and Regulations

Organization	Standard	Reference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION		FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES	Supported	RBREV* -,159,1998
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 0.1 ppm (0.25 mg/m³)	DTLVS* 3,5,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypt	time-weighted average 0.1 ppm (0.25 mg/m³), JAN1993
Occupational Exposure Limit-AUSTRALIA	time-weighted average 0.1 ppm (0.23 mg/m³), short term exposure limit 0.3 ppm, (0.69 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 0.1 ppm (0.25 mg/m³);KZW 0.1 ppm (0.25 mg/m³), skin, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 0.1 ppm (0.23 mg/m³), MAR2002
Occupational Exposure Limit-BELGIUM	short term exposure limit 0.3 ppm (0.7 mg/m³), MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 0.05 ppm (0.12 mg/m³), MAY2011
Occupational Exposure Limit-FINLAND	ceiling concentration 0.1 ppm (0.23 mg/m³), NOV2011
Occupational Exposure Limit-FRANCE	VLE 0.1 ppm (0.25 mg/m³), FEB2006
Occupational Exposure Limit-HUNGARY	time-weighted average 0.23 mg/m³, short term exposure limit 0.23 mg/m³, SEP2000
Occupational Exposure Limit-ICELAND	time-weighted average 0.1 ppm (0.2 mg/m³), NOV2011
Occupational Exposure Limit-JAPAN	Occupational Exposure Limit 0.1 ppm (0.23 mg/m³), MAY2012
Occupational Exposure Limit-KOREA	time-weighted average 0.1 ppm (0.25 mg/m³), short term exposure limit 0.3 ppm (0.8 mg/m³), 2006
Occupational Exposure Limit-MEXICO	time-weighted average 0.1 ppm (0.25 mg/m³);short term exposure limit 0.3 ppm (0.8 mg/m³), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 0.1 ppm (0.23 mg/m³), JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 0.1 ppm (0.25 mg/m³), JAN1999
Occupational Exposure Limit-PERU	short term exposure limit 0.1 ppm (0.23 mg/m³), JUL2005
Occupational Exposure Limit-POLAND	MAC(time-weighted average) 0.2 mg/m³, MAC(short term exposure limit) 0.5 mg/m³, JAN1999
Occupational Exposure Limit-RUSSIA	short term exposure limit 0.2 mg/m³, JUN2003
Occupational Exposure Limit-SWEDEN	time-weighted average 0.1 ppm (0.2 mg/m³);short term exposure limit 0.3 ppm (0.7 mg/m³), JUN2005
Occupational Exposure Limit-SWITZERLAND	ceiling concentration 0.1 ppm (0.25 mg/m³), JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 0.05 mg/m³, 2003
Occupational Exposure Limit-THE PHILIPPINES	time-weighted average 0.1 ppm (0.25 mg/m³), JAN1993
Occupational Exposure Limit-TURKEY	time-weighted average 0.1 ppm (0.25 mg/m³), JAN1993
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 0.1 ppm (0.23 mg/m³);short term exposure limit 0.3 ppm, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 0.1 ppm (0.25 mg/m³)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 0.1 ppm (0.25 mg/m³)	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 0.1 ppm (0.25 mg/m³)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 0.1 ppm (0.25 mg/m³)	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ACROLEIN-air	10H time-weighted average 0.1 ppm;short term exposure limit 0.3 ppm	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 03530; Number of Industries 4; Total Number of Facilities 37; Number of Occupations 18; Total Number of Employees Exposed 1298; Total Number of Female Employees Exposed 5
National Occupational Hazard Survey 1974	Hazard Code 03530; Number of Industries 16; Total Number of Facilities 845; Number of Occupations 25; Total Number of Employees Exposed 7299

Status in Federal Agencies

Organization	Reference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/91/180307/AS)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Acrolein, 2501
NIOSH Analytical Method, 1994: Aldehydes, screening, 2539
NIOSH CURRENT INTELLIGENCE BULLETIN #55, September 1991
NTP Carcinogenesis studies; test completed (peer review), October 2000
On EPA IRIS database
OSHA ANALYTICAL METHOD #52

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Page last reviewed:March 7, 2014
Page last updated:February 6, 2017
Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division

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