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Registry of Toxic Effects of Chemical Substances (RTECS)

Acetonitrile, hydroxy-

RTECS #

AM0350000

CAS #

107-16-4

Updated

July 2000

Molecular Weight

57.06

Molecular Formula

C2H3NO

Synonyms

2-Hydroxyacetonitrile
Cyanomethanol
Formaldehyde cyanohydrin
Glycolic nitrile
Glycolonitrile (8CI)
Glyconitrile
Glykolonitril (Czech)
Hydroxyacetonitrile
Hydroxyazetonitril (German)
Hydroxymethylkyanid (Czech)
Hydroxymethylnitrile
USAF A-8565

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 500 mg/24H mild85JCAE -,915,1986

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse Lowest published lethal concentration: 27 ppm/8HEye: Lacrimation

Behavioral: Somnolence (general depressed activity)
34ZIAG -,290,1969
inhalation/rat Lowest published lethal concentration: 27 ppm/8HEye: Lacrimation

Behavioral: Somnolence (general depressed activity)
34ZIAG -,290,1969
intraperitoneal/mouse lethal dose (50 percent kill): 3 mg/kgZAARAM 19,225,1969
ocular/rabbit lowest published lethal dose: 13 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Coma
34ZIAG -,290,1969
oral/mouse lethal dose (50 percent kill): 10 mg/kg34ZIAG -,290,1969
oral/rat lethal dose (50 percent kill): 8 mg/kgZAARAM 19,225,1969
skin/rabbit lethal dose (50 percent kill): 5 mg/kgSkin: After topical application: Primary irritationAIHAAP 23,95,1962
subcutaneous/mouse lowest published lethal dose: 15 mg/kgAIPTAK 12,447,1904

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-TURKEYtime-weighted average 1 ppm (5 mg/m3), short term exposure limit 2 ppm, Skin, JAN1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO GLYCOLONITRILE-airceiling concentration 2.0 ppm/15MNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code X6125; Number of Industries 1; Total Number of Facilities 8; Number of Occupations 18; Total Number of Employees Exposed 1433

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9040
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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