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Registry of Toxic Effects of Chemical Substances (RTECS)

Acetaldehyde, chloro-

RTECS #

AB2450000

CAS #

107-20-0

Updated

September 201

Molecular Weight

78.50

Molecular Formula

C2H3ClO

Synonyms

2-Chloro-1-ethanal
2-Chloroacetaldehyde
2-Chloroethanal
Chloroacetaldehyde
Chloroacetaldehyde (ACGIH:OSHA)
Chloroacetaldehyde monomer
Monochloroacetaldehyde
RCRA waste number P023

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA adducttestis/salmon3 gmCRNGDP 3,663,1982
DNA adductlymphocyte/mammal (species unspecified)200 mmol/LCBINA8 22,211,1978
DNA adduct/Escherichia coli50 mmol/L/30MMUREAV 684,24,2010
DNA Damageliver/rat47 mmol/LTOLED5 42,183,1988
DNA Damagelymphocyte/human100 µmol/LEMMUEG 20,277,1992
DNA Damagesperm/salmon20 mmol/LCNREA8 48,4804,1988
DNA inhibitionintravenous/rat5 gm/kgCBINA8 17,239,1977
DNA repair/Bacillus subtilis100 mmol/L37ATAD -,155,1977
DNA repair/Escherichia coli10 mg/plateEVHPAZ 21,79,1977
mutation in mammalian somatic cellslymphocyte/human16 µmol/LCRNGDP 18,31,1997
mutation in mammalian somatic cellslung/hamster6400 nmol/LIJCNAW 16,639,1975
mutation in microorganisms/Bacillus subtilis5 mmol/L (-enzymatic activation step)MSERDS 5,131,1981
mutation in microorganisms/Salmonella typhimurium400 µmol/L (+enzymatic activation step)MUREAV 32,93,1975
mutation in microorganisms/Escherichia coli1 mmol/L (-enzymatic activation step)CBINA8 12,265,1976
mutation in microorganisms/Other microorganisms250 µg/plate (-enzymatic activation step)CBINA8 30,9,1980
mutation in microorganisms/Other microorganisms1 mmol/L (-enzymatic activation step)MUREAV 73,1,1980
mutation in microorganisms/Saccharomyes cerevisiae3100 µmol/L (+enzymatic activation step)CNREA8 37,253,1977
mutation in microorganisms/Aspergillus nidulans30 mg/plate (-enzymatic activation step)CBINA8 30,9,1980
mutation in microorganisms/Schizosaccharomyces pombe6250 µmol/L (+enzymatic activation step)CNREA8 37,253,1977
other mutation test systems/Bacillus subtilis1 mole/L37ATAD -,155,1977

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig Lowest published lethal concentration: 400 ppm/30MEye: Other eye effects

Behavioral: Hallucinations, distorted perceptions

Lung, Thorax, or Respiration: Dyspnea		NTIS** OTS0536151
inhalation/rat lethal concentration (50 percent kill): 650 mg/m3/1HVascular: BP elevation not characterized in autonomic section

Lung, Thorax, or Respiration: Respiratory obstruction

Lung, Thorax, or Respiration: Other changes		EPASR* 8EHQ-0387-0660
intraperitoneal/guinea pig lethal dose (50 percent kill): 2523 µg/kgJPMSAE 61,19,1972
intraperitoneal/mouse lethal dose (50 percent kill): 7 mg/kgJPMSAE 61,19,1972
intraperitoneal/rabbit lethal dose (50 percent kill): 5522 µg/kgJPMSAE 61,19,1972
intraperitoneal/rat lethal dose (50 percent kill): 7 mg/kgJPMSAE 61,19,1972
oral/mouse lethal dose (50 percent kill): 82 mg/kgJPMSAE 61,19,1972
oral/rat lethal dose (50 percent kill): 89 mg/kgJPMSAE 61,19,1972
skin/rabbit lethal dose (50 percent kill): 267 mg/kgJPMSAE 61,19,1972

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat lowest published toxic dose: 113 mg/kg/30D- intermittentBrain and Coverings: Changes in brain weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		JPMSAE 61,19,1972
parenteral/rat lowest published toxic dose: 58 mg/kg/12W- intermittentLung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Blood: Changes in erythrocyte (RBC) count

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		JPMSAE 61,19,1972

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-ceiling concentration 1 ppmDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWMUREAV 636,178,2007
TOXICOLOGY REVIEWMUREAV 727,1,2011
TOXICOLOGY REVIEWMUREAV 727,42,2011
TOXICOLOGY REVIEWTXCYAC 286,1,2011

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARDair-ceiling concentration 1 ppm (3 mg/m3)DTLVS* 3,48,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypttime-weighted average 1 ppm (3 mg/m3), JAN1993
Occupational Exposure Limit-AUSTRALIAceiling concentration 1 ppm (3.2 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 1 ppm (3 mg/m3);KZW 1 ppm (3 mg/m3), skin, 2007
Occupational Exposure Limit-BELGIUMshort term exposure limit 1 ppm (3.2 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKceiling concentration 1 ppm (3 mg/m3), carc, MAY2011
Occupational Exposure Limit-FINLANDshort term exposure limit 1 ppm (3.3 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVLE 1 ppm (3 mg/m3), C3 Carcinogen, FEB2006
Occupational Exposure Limit-ICELANDshort term exposure limit 1 ppm (3 mg/m3), NOV2011
Occupational Exposure Limit-KOREAceiling concentration 1 ppm (3 mg/m3), 2006
Occupational Exposure Limit-MEXICOpeak 1 ppm (3 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDceiling concentration 1 ppm (3.2 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 1 ppm (3 mg/m3), JAN1999
Occupational Exposure Limit-PERUshort term exposure limit 1 ppm (3.2 mg/m3), JUL2005
Occupational Exposure Limit-SWITZERLANDceiling concentration 1 ppm (3 mg/m3), carc 3, JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 1 ppm (3 mg/m3), JAN1993
Occupational Exposure Limit-THE NETHERLANDSMAC-C 3 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 1 ppm (3 mg/m3), JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 1 ppm (3 mg/m3), JAN1993
Occupational Exposure Limit-UNITED KINGDOMshort term exposure limit 1 ppm (3.3 mg/m3), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)ceiling concentration 1 ppm (3 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)ceiling concentration 1 ppm (3 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)ceiling concentration 1 ppm (3 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)ceiling concentration 1 ppm (3 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CHLOROACETALDEHYDE-airceiling concentration 1 ppmNIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974Hazard Code 18065; Number of Industries 1; Total Number of Facilities 21; Number of Occupations 3; Total Number of Employees Exposed 788

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Negative: S pombe-forward mutation
EPA GENETOX PROGRAM 1988, Positive: E coli polA without S9; Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion
EPA GENETOX PROGRAM 1988, Positive: V79 cell culture-gene mutation
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Chloroacetaldehyde, 2015
OSHA ANALYTICAL METHOD #76

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