Skip Navigation LinksSkip Navigation Links
Centers for Disease Control and Prevention
Safer Healthier People
Blue White
Blue White
bottom curve
CDC Home Search Health Topics A-Z spacer spacer
spacer
Blue curve MMWR spacer
spacer
spacer

Persons using assistive technology might not be able to fully access information in this file. For assistance, please send e-mail to: mmwrq@cdc.gov. Type 508 Accommodation and the title of the report in the subject line of e-mail.

Blood Safety Monitoring Among Persons with Bleeding Disorders --- United States, May 1998--June 2002

Since 1998, CDC has collaborated with approximately 140 federally funded hemophilia treatment centers (HTCs) in the United States and its territories through the Universal Data Collection (UDC) surveillance project to monitor blood product safety and detect new viral hepatitis and human immunodeficiency virus (HIV) infections. This report presents findings of investigations conducted during May 1998--June 2002 of 1,149 seroconversions* for hepatitis viruses identified among persons with bleeding disorders who were enrolled voluntarily in UDC; 99% of hepatitis A virus (HAV) seroconversions and 90% of hepatitis B virus (HBV) seroconversions were attributed to vaccination programs against HAV or HBV. None of these cases was attributable to blood products received during this time, which indicates that the virally inactivated blood factor concentrates used to treat bleeding disorders are unlikely to transmit viral hepatitis. Regular monitoring of patients ensures the continued safety of blood and blood products.

HTC staff obtain informed consent from each UDC participant and collect a standard set of clinical data and a plasma specimen. Data presented on standardized registration, annual, and laboratory forms are sent to CDC along with annual blood specimens from all UDC patients. Specimen remainders are stored in a blood-safety repository for future investigations of blood safety. All plasma specimens are tested for hepatitis viruses at Baylor College of Medicine. UDC participants are tested for hepatitis at enrollment according to algorithms that determine whether patients have been exposed to or infected with a virus. Participants who test negative for a virus are retested in subsequent years to monitor for seroconversions. Possible seroconversions are evaluated for HAV by testing for IgM antibody to HAV and total antibody to HAV; for HBV by testing for antibody to hepatitis B surface antigen (anti-HBs), antibody to hepatitis B core antigen (anti-HBc), and hepatitis B surface antigen (HBsAg); and for hepatitis C virus (HCV) by testing for antibody to hepatitis C (anti-HCV), which is confirmed with recombinant immunoblot assay and/or HCV-RNA by polymerase chain reaction when needed.

Systematic investigations were conducted when patients were confirmed as seropositive after having tested seronegative in a previous UDC specimen. Laboratory results were compared with information about past infections and vaccinations and with data about exposure to blood components or plasma derivatives. If the change in laboratory results could not be explained on the basis of these data, CDC contacted HTC staff for additional information on other potential risk factors for infection and on the setting of potential transmission, including blood-product manufacturer and lot number. Resolution of discrepancies generally required repeat testing of previously drawn specimens; less often, repeat testing was performed on newly drawn specimens. Patients' identities were not disclosed by HTCs.

During May 1998--June 2002, a total of 11,171 patients with hemophilia and other bleeding disorders were enrolled in UDC; 6,931 (62%) had hemophilia A, 1,866 (16%) had hemophilia B, 2,078 (19%) had von Willebrand disease, and 296 (3%) had other congenital bleeding disorders. A total of 6,219 (56%) patients were newly enrolled in UDC and so had been tested only once; these persons will be tested again in subsequent years. Of the 4,952 (44%) patients who had blood testing in >2 years, 1,149 (23%) had seroconversions to hepatitis viruses: 896 (18%) to anti-HAV; 252 (5%) to anti-HBs, anti-HBc, or HBsAg; and one (<1%) to anti-HCV. Because 896 (99%) HAV seroconversions and 227 (90%) HBV seroconversions could be attributed to vaccination programs, and the remainder could be attributed to other sources, no seroconversions were attributed to exposure to blood derivatives used during the surveillance interval.

No participants who seroconverted to anti-HAV were IgM-positive when the tests were performed. Being IgM-positive is a marker of acute infection with HAV that persists for 3--6 months in the majority of patients (1).

Of 896 persons who seroconverted to total anti-HAV in the second year of testing, 890 (99%) had completed the hepatitis A vaccination series, had received a booster injection, or were in the process of being vaccinated. Because none of the six participants who seroconverted in the absence of vaccination had received blood products between tests, these infections were presumed to be community-acquired.

Of 252 persons who seroconverted to one or more HBV markers, 227 (90%) who seroconverted only to anti-HBs had received either a full, partial, or booster vaccination between their first- and second-year tests. The remaining 25 who tested negative in initial UDC testing for anti-HBs, anti-HBc, or HBsAg and then tested positive subsequently were documented by HTC staff to have a previous history of HBV infection caused by past exposure to blood products. All these 25 participants also were HIV-infected from blood products used before enrollment in UDC.

One seroconversion for HCV occurred 6 months after collection of an initial negative UDC specimen. Local health authorities investigated this seroconversion and determined that the most likely source of this infection was injection-drug use; the patient's HIV status was negative.

Reported by: FB Hollinger, MD, Baylor College of Medicine, Houston, Texas. A Kirtava, MD, M Oakley, DVM, M Soucie, PhD, B Evatt, MD, Div of AIDS, STD, and TB Laboratory Research, National Center for Infectious Diseases, CDC.

Editorial Note:

HTCs provide care to 70% of persons in the United States with bleeding disorders. UDC is the largest data collection system monitoring persons receiving plasma derivatives, and infections transmitted by blood and blood products often are identified first in this sentinel population (2). A high risk for bloodborne viral infections (including HBV and HCV) among persons with bleeding disorders was associated with the use of clotting factor concentrates prepared from large pools of human plasma manufactured during the 1970s and early 1980s before the development of viral inactivation procedures (3,4). In the early 1990s, several outbreaks of HAV associated with the receipt of clotting factors were reported in Europe and the United States (5,6).

Investigations of seroconversions during May 1998--July 2002 did not document new cases of viral hepatitis infections that were attributed to blood products received during the time interval between laboratory tests. The majority of seroconversions for HAV and HBV were associated with vaccination (99% and 90%, respectively). The other seroconversions probably were caused either by community-acquired infection (for the six HAV infections) or by fluctuations in antibody levels that occur among HIV-infected patients (for the 25 persons with HBV seroconversions who also were infected with HIV) (7).

This report suggests that currently available blood factor concentrates most likely do not transmit HBV or HCV. Transmission of HAV remains a remote risk because the viral inactivation procedures used for plasma derivatives are unable to inactivate non-enveloped viruses such as HAV completely (8). Sporadic cases occur when plasma obtained from an asymptomatic donor who is incubating the infection is added inadvertently to a plasma pool used to manufacture derivatives. Because of the wide distribution of these products, such sporadic product-related cases can be identified only by monitoring large populations for clusters of cases that occur at the same time and that are associated with the use of a single product lot.

The findings in this report are subject to at least two limitations. First, because not all persons with bleeding disorders participated in the surveillance, some seroconversions might have been missed. Second, because patient or health-care provider reports of vaccination were used instead of medical record documentation, some seroconversions might have been attributed incorrectly to vaccination.

UDC promotes prevention and reduction of the complications of bleeding disorders and provides health agencies with timely risk data to support policy decision making. In addition, UDC has led to high levels of vaccination coverage, which is recommended for persons with bleeding disorders (9,10). Regular testing of patients with bleeding disorders through UDC monitors the safety of blood and blood products and provides the national repository of stored serum for assessment of potential new threats to the blood supply.

Acknowledgment

This article is based on data supplied by the staff of federally funded hemophilia treatment centers who enrolled patients in the surveillance system and assisted with the investigations.

References

  1. Kao HW, Ashcavai M, Redeker AG. The persistence of hepatitis A IgM antibody after acute clinical hepatitis A. Hepatology 1984;4:933--6.
  2. Soucie JM, Jackson D, Evatt B. The occurrence of hemophilia in the United States. Am J Hematol 1998;59:288--94.
  3. Gjerset GF, Clements MJ, Counts RB, Halvorsen AS, Thompson AR. Treatment type and amount influenced human immunodeficiency virus seroprevalence of patients with congenital bleeding disorders. Blood 1991;78:1623--7.
  4. Kasper CK, Kipnis SA. Hepatitis and clotting factor concentrates. JAMA 1972;221:510.
  5. Mannucci PM, Gdovin S, Gringeri A, et al. Transmission of hepatitis A to patients with hemophilia by factor VIII concentrates treated with organic solvent and detergent to inactivate viruses. Ann Intern Med 1994;120:1--7.
  6. Soucie JM, Robertson BH, Bell BP, McCaustland KA, Evatt BL. Hepatitis A virus infections associated with clotting factor concentrate in the United States. Transfusion 1998;38:573--9.
  7. Kisker CT, Mahoney EM, Arkin S, Maeder MA, Donfield SM, Evatt BL. Changes in hepatitis B serologic titers in HIV+ and HIV- children with hemophilia. Hemophilia 1999;5:354--9.
  8. Richardson LC, Evatt BL. Risk of hepatitis A virus in persons with hemophilia receiving plasma-derived products. Transfusion 2000;14:64--73.
  9. CDC. Hepatitis B virus: a comprehensive strategy for eliminating transmission in the United States through universal childhood vaccination: recommendations of the Immunization Practices Advisory Committee. MMWR 1991;40(No. RR-13).
  10. CDC. Prevention of hepatitis A through active or passive immunization: recommendations of the Advisory Committee on Immunization Practices. MMWR 1999;48(No. RR-12).

* A change of test results from negative in year one of testing to positive in the subsequent year of testing for any reason (e.g., vaccination or other risk factors). Seroconversion is an expected outcome for vaccination.

Use of trade names and commercial sources is for identification only and does not imply endorsement by the U.S. Department of Health and Human Services.


References to non-CDC sites on the Internet are provided as a service to MMWR readers and do not constitute or imply endorsement of these organizations or their programs by CDC or the U.S. Department of Health and Human Services. CDC is not responsible for the content of pages found at these sites. URL addresses listed in MMWR were current as of the date of publication.

Disclaimer   All MMWR HTML versions of articles are electronic conversions from ASCII text into HTML. This conversion may have resulted in character translation or format errors in the HTML version. Users should not rely on this HTML document, but are referred to the electronic PDF version and/or the original MMWR paper copy for the official text, figures, and tables. An original paper copy of this issue can be obtained from the Superintendent of Documents, U.S. Government Printing Office (GPO), Washington, DC 20402-9371; telephone: (202) 512-1800. Contact GPO for current prices.

**Questions or messages regarding errors in formatting should be addressed to mmwrq@cdc.gov.

Page converted: 1/2/2003

HOME  |  ABOUT MMWR  |  MMWR SEARCH  |  DOWNLOADS  |  RSSCONTACT
POLICY  |  DISCLAIMER  |  ACCESSIBILITY

Safer, Healthier People

Morbidity and Mortality Weekly Report
Centers for Disease Control and Prevention
1600 Clifton Rd, MailStop E-90, Atlanta, GA 30333, U.S.A

USA.GovDHHS

Department of Health
and Human Services

This page last reviewed 1/2/2003