Rehydration Therapy
Rehydration is the cornerstone of treatment for cholera. Oral rehydration salts and, when necessary, intravenous fluids and electrolytes, if administered in a timely manner and in adequate volumes, will reduce fatalities to well under 1% of all patients.
Low-osmolarity oral rehydration solution and cereal-based oral rehydration solution are the preferred replacement fluids for most patients. However, WHO’s Guidelines for the Inpatient treatment of Severely Malnourished Children[PDF - 51 pages] (see Appendix 3) includes guidance for making a modified rehydration solution called ReSoMal that was formulated for rehydration of severely malnourished children. Breastfed children should also continue to breastfeed. Other types of fluids, such as juice, soft drinks, and sports drinks should be avoided.
Key Points About Rehydration
- Rapid high-volume rehydration will save lives
- Many patients can be rehydrated entirely with oral rehydration solution ORS)
- Even if the patient gets intravenous (IV) rehydration, he/she should start drinking ORS as soon as he/she is able
Watch the following video: Managing Dehydration
Signs and Symptoms of Dehydration
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Moderate Dehydration
- Restlessness and irritability
- Sunken eyes
- Dry mouth and tongue
- Increased thirst
- Skin goes back slowly when pinched
- Decreased urine
- Decreased tears, depressed fontanels in infants
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Severe Dehydration
- Lethargy or unconsciousness
- Very dry mouth and tongue
- Skin goes back very slowly when pinched ("tenting")
- Weak or absent pulse
- Low blood pressure
- Minimal or no urine
References
- Alam NH, Hamadani JD, Dewan N, Fuchs GJ. Efficacy and safety of a modified oral rehydration solution (ReSoMaL) in the treatment of severely malnourished children with watery diarrhea. J Pediatr. 2003;143(5):614-9.
- Daniels NA, Simons SL, Rodrigues A, Gunnlaugsson G, Forster TS, Wells JG, Hutwagner L, Tauxe RV, Mintz ED. First do no harm: making oral rehydration solution safer in a cholera epidemic. Am J Trop Med Hyg. 1999;60(6):1051-5.
- Gregorio GV, Gonzales ML, Dans LF, Martinez EG. Polymer-based oral rehydration solution for treating acute watery diarrhoea [PDF – 65 pages]. Cochrane Database Syst Rev. 2009;(2):CD006519.
- Hahn S, Kim Y, Garner P. Reduced osmolarity oral rehydration solution for treating dehydration caused by acute diarrhea in children. Cochrane Database Syst Rev. 2002;(1):CD002847.
- WHO. First steps for managing an outbreak of acute diarrhea[PDF – 2 pages]. WHO Global Task Force on Cholera Control. 2004.
- WHO. WHO position paper on Oral Rehydration Salts to reduce mortality from cholera[PDF – 1 page]. WHO Global Task Force on Cholera Control. 2008 Dec.
- Reaching Every District (RED) Approach: A way to improve immunization performance. B World Health Organ. 2008;86(3):161-240
- World Health Organization. Management of the Patient with Cholera. Geneva, Switzerland: World Health Organization, Programme for Control of Diarrhoeal Diseases, 1992. (WHO/CDO/SER/15 rev 1)
- Page last reviewed: November 7, 2014
- Page last updated: November 7, 2014
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