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HPV-Associated Cancer Trends by Year

The rate of people getting HPV-associated cancers varies by year and type of cancer. “Incidence rate” means how many people out of a given number get the disease each year.

*Note: This study used cancer registry data to estimate the amount of HPV-associated cancer in the United States by examining cancer in parts of the body and cancer cell types that are more likely to be caused by HPV. Cancer registries do not collect data on the presence or absence of HPV in cancer tissue at the time of diagnosis. In general, HPV is thought to be responsible for more than 90% of anal and cervical cancers; more than 50% of vaginal, vulvar, and penile cancers; and 60% to 70% of oropharyngeal cancers.

Number of HPV-Associated Cancers by Year and Sex, United States, 2003–2013

The number of cases of HPV-associated cancers has increased from 2003 to 2013 for both men and women. Among men, there were 11,314 HPV-associated cancer cases in 2003, 11,908 in 2004, 12,226 in 2005, 12,541 in 2006, 13,755 in 2007, 14,767 in 2008, 15,349 in 2009, 15,614 in 2010, 16,633 in 2011, 17,031 in 2012, and 17,944 in 2013. Among women, there were 20,742 HPV-associated cancer cases in 2003, 20,816 in 2004, 21,352 in 2005, 21,548 in 2006, 22,167 in 2007, 22,455 in 2008, 23,145 in 2009, 22,946 in 2010, 23,392 in 2011, 23,518 in 2012, and 23,651 in 2013.

HPV-Associated Cancer Rates by Year and Sex, United States, 2003–2013

The rates of HPV-associated cancers from 2003 to 2013 increased among men and and were stable among women, increasing slightly among men and women overall. The overall rates were 10.97 cases per 100,000 persons in 2003, 11.01 in 2004, 11.09 in 2005, 11.06 in 2006, 11.44 in 2007, 11.61 in 2008, 11.80 in 2009, 11.57 in 2010, 11.78 in 2011, 11.74 in 2012, 11.79 in 2013. The rates for women were 13.48 cases per 100,000 women in 2003, 13.36 in 2004, 13.53 in 2005, 13.47 in 2006, 13.65 in 2007, 13.61 in 2008, 13.86 in 2009, 13.49 in 2010, 13.56 in 2011, 13.43 in 2012, 13.26 in 2013. The rates for men were 8.24 cases per 100,000 men in 2003, 8.45 in 2004, 8.46 in 2005, 8.46 in 2006, 9.08 in 2007, 9.48 in 2008, 9.61 in 2009, 9.56 in 2010, 9.94 in 2011, 9.99 in 2012, 10.29 in 2013.

Rates are per 100,000 and age-adjusted to the 2000 U.S. Standard Population (19 age groups — Census P25-1130) standard.

Data are from population-based cancer registries participating in the CDC National Program of Cancer Registries and/or the NCI Surveillance, Epidemiology, and End Results Program, meeting criteria for high data quality for all years 2003–2013, and covering about 99% of the U.S. population.

HPV-associated cancers were defined as cancers at specific anatomic sites and with specific cellular types in which HPV DNA frequently is found. All cancers were confirmed histologically. Cervical cancers (ICD-O-3 site codes C53.0–C53.9) are limited to carcinomas (ICD-O-3 histology codes 8010–8671, 8940–8941). Vaginal (ICD-O-3 site code C52.9), vulvar (ICD-O-3 site codes C51.0–C51.9), penile (ICD-O-3 site codes C60.0–60.9), anal (ICD-O-3 site code C21.0–C21.9), rectal (ICD-O-3 site code C20.9) and oropharyngeal (ICD-O-3 site codes C01.9, C02.4, C02.8, C05.1, C05.2, C09.0, C09.1, C09.8, C09.9, C10.0, C10.1, C10.2, C10.3, C10.4, C10.8, C10.9, C14.0, C14.2 and C14.8) cancer sites are limited to squamous cell carcinomas (ICD-O-3 histology codes 8050–8084, 8120–8131).

Reference

Viens LJ, Henley SJ, Watson M, Markowitz LE, Thomas CC, Thompson TD, Razzaghi H, Saraiya M, Centers for Disease Control and Prevention (CDC). Human papillomavirus–associated cancers—United States, 2008–2012. MMWR 2016;65(26):661–666.

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