Trophoblasts (from Greek trephein: to feed; and blastos: germinator) are cells forming the outer layer of a blastocyst, which provide nutrients to the embryo and develop into a large part of the placenta. They are formed during the first stage of pregnancy and are the first cells to differentiate from the fertilized egg. This layer of trophoblasts is also collectively referred to as "the trophoblast",[1] or, after gastrulation,[2] the trophectoderm, as it is then contiguous with the ectoderm of the embryo.

Blastocyst with an inner cell mass and trophoblast.
Gives rise tocaul
Latintrophoblastus; massa cellularis externa
Anatomical terminology


The trophoblast proliferates and differentiates into two cell layers at approximately six days after fertilization for humans:

cytotrophoblastinner layerSingle celled, inner layer of the trophoblast.
syncytiotrophoblastouter layerThick layer that lacks cell boundaries and grows into the endometrial stroma. It secretes hCG in order to maintain progesterone secretion and sustain a pregnancy.
intermediate trophoblast (IT)implantation site, chorion, villi (dependent on subtype)anchor placenta (implanation site IT), unknown (chorionic & villus IT)


Trophoblasts are specialized cells of the placenta that play an important role in embryo implantation and interaction with the decidualised maternal uterus. The core of placental villi contain mesenchymal cells and placental blood vessels that are directly connected to the fetal circulation via the umbilical cord. This core is surrounded by two layers of trophoblast; a single layer of mononuclear cytotrophoblast that fuse together to form the overlying multinucleated syncytiotrophoblast layer that covers the entire surface of the placenta. It is this syncytiotrophoblast that is in direct contact with the maternal blood that reaches the placental surface, and thus facilitates the exchange of nutrients, wastes and gases between the maternal and fetal systems.

In addition, cytotrophoblast in the tips of villi can differentiate into another type of trophoblast called the extravillous trophoblast. Extravillous trophoblast grow out from the placenta and penetrate into the decidualised uterus. This process is essential not only for physically attaching the placenta to the mother, but also for altering the vasculature in the uterus to allow it to provide an adequate blood supply to the growing fetus as pregnancy progresses. Some of these trophoblast even replace the endothelial cells in the uterine spiral arteries as they remodel these vessels into wide bore conduits that are independent of maternal vasoconstriction. This ensures the fetus receives a steady supply of blood, and the placenta is not subjected to fluctuations in oxygen that could cause it damage.

Clinical significance

The invasion of a specific type of trophoblast (extravillous trophoblast) into the maternal uterus is a vital stage in the establishment of pregnancy. Failure of the trophoblast to invade sufficiently is important in the development of some cases of pre-eclampsia. Too firm an attachment may lead to placenta accreta.

Gestational trophoblastic disease represents a form of proliferation.

Additional images

See also


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