Trimix (drug)

Trimix is an injectable three-drug prescribed medication used to treat erectile dysfunction. The active ingredients in the mixture are usually alprostadil, papaverine, and phentolamine. The injection must be compounded by a pharmacy and administered via intracavernosal injection (an injection at either side, not the base, of the penis).[1][2][3] Trimix is typically compounded by a pharmacy in a sterile environment and then frozen. The compound is stable for up to six months while stored frozen and for one month if stored refrigerated beginning at the time of manufacture.[4]

Trimix
Combination of
Alprostadilprostaglandin
Papaverinevasodilator
Phentolaminealpha blocker
Clinical data
Pregnancy
category
  • US: D (Evidence of risk)
    Routes of
    administration    		injection, topical
    Legal status
    Legal status
    Identifiers
    ChemSpider
    • none
      (verify)

    References
    1. R Seyam, K Mohamed, A Al Akhras and H Rashwan (2005). "A prospective randomized study to optimize the dosage of trimix ingredients and compare its efficacy and safety with prostaglandin E1". International Journal of Impotence Research. 17 (4): 346–353. doi:10.1038/sj.ijir.3901313. PMID 15772683.CS1 maint: multiple names: authors list (link)
    2. S.C. Kim; I.H. Chang; H.J. Jeon (August 2003). "Preference for oral sildenafil or intracavernosal injection in patients with erectile dysfunction already using intracavernosal injection for > 1 year". BJU International. 92 (3): 277–280. doi:10.1046/j.1464-410X.2003.04324.x. PMID 12887483.
    3. S. Israilov; Baniel, J; Shmueli, J; Niv, E; Engelstein, D; Segenreich, E; Livne, PM (2004). "Treatment program for erectile dysfunction in patients with cardiovascular diseases". The American Journal of Cardiology. 93 (6): 689–693. doi:10.1016/j.amjcard.2003.11.049. PMID 15019870.
    4. Trissel Lawrence A; Zhang Yanping (May–June 2004). "Long-Term Stability of Trimix: A Three-Drug Injection Used to Treat Erectile Dysfunction". International Journal of Pharmaceutical Compounding: 231–235.


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