Spleen transplantation

Spleen transplantation is the transfer of spleen or spleen fragments from one individual to another. It is under research for induction of immunological tolerance for other transplanted organs. Success has been achieved in rodent models. Recently, evidence has been obtained for a tolerogenic effect of a spleen transplant in miniature swine (Frank JMF Dor, PhD thesis). Also, the spleen harbors primitive hematopoietic progenitor cells. Spleen transplantation surgery has been performed on humans with mixed results.[1][2]

Spleen transplantation


Splenic tissue can be deliberately autotransplanted after splenectomy, as some tissue will still be viable, to attempt to preserve some splenic function (to attempt to prevent OPSI). Usually this involves leaving parts of splenic parenchyma in pouches of omentum. This is not without risk or complication. This was performed after splenosis was understood; splenosis is the reimplantation of splenic tissue elsewhere in the body (usually the abdomen) after it has broken off from the spleen due to trauma or surgery.

See Also


  1. Wu; et al. (January 2011). "Graft-versus-host disease after intestinal and multivisceral transplantation". Transplantation. 91 (2): 219–224. doi:10.1097/tp.0b013e3181ff86ec. PMID 21076376.
  2. Deierhoi; et al. (April 1986). "Lethal graft-versus-host disease in a recipient of a pancreas-spleen transplant". Transplantation. 41 (4): 544–546. doi:10.1097/00007890-198604000-00028. PMID 3515658.

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