Reynolds' pentad

Reynolds pentad is a collection of signs and symptoms suggesting the diagnosis obstructive ascending cholangitis, a serious infection of the biliary system. It is a combination of Charcot's triad (right upper quadrant pain, jaundice, and fever) with shock (low blood pressure, tachycardia) and an altered mental status.[1] Sometimes the two additional signs are listed simply as low blood pressure and confusion.[2]

Reynolds' pentad
Differential diagnosisobstructive ascending cholangitis


It was named after the surgeon, B.M. Reynolds, who described it in 1959 along with Dr. Everett L. Dargan.[1]


  1. Reynolds BM, Dargan EL (August 1959). "Acute obstructive cholangitis; a distinct clinical syndrome". Ann Surg. 150 (2): 299–303. doi:10.1097/00000658-195908000-00013. PMC 1613362. PMID 13670595.
  2. Teo, Amir H. Sam, James T.H. (2010). Rapid medicine (2nd ed.). Chichester, West Sussex, UK: Wiley-Blackwell. ISBN 1405183233.

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