Psammoma body

A psammoma body is a round collection of calcium, seen microscopically. The term is derived from the Greek word ψάμμος (psámmos), meaning "sand".

Micrograph of psammoma body in the centre of the field in a meningioma of brain. H&E stain.

Cause

Psammoma bodies are associated with the papillary (nipple-like) histomorphology and are thought to arise from,

Infarction and calcification of papillae tips.
Calcification of intralymphatic tumor thrombi.[1]

Association with lesions

Psammoma bodies are commonly seen in certain tumors such as:

Papillary thyroid carcinoma
Papillary renal cell carcinoma
Ovarian papillary serous cystadenoma and cystadenocarcinoma[2]
Endometrial adenocarcinomas (Papillary serous carcinoma ~3%-4%)
Meningiomas, in the central nervous system[3]
Peritoneal and Pleural Mesothelioma
Somatostatinoma (pancreas)[4]
Prolactinoma of the pituitary [5]
Glucagonoma
Micropapillary subtype of Lung Adenocarcinoma[6]

Benign lesions

Micrograph of a psammomatous melanotic schwannoma with a psammoma body, as may be seen in Carney complex. H&E stain.

Psammoma bodies may be seen in:

Endosalpingiosis[7]
Psammomatous melanotic schwannoma
Melanocytic nevus[8]

Appearance

Psammoma bodies usually have a laminar appearance, are circular, acellular and basophilic.

References

Johannessen JV, Sobrinho-Simões M (September 1980). "The origin and significance of thyroid psammoma bodies". Lab. Invest. 43 (3): 287–96. PMID 7401638.
Ovarian papillary serous cystadenocarcinoma at WebPath, The Internet Pathology Laboratory for Medical Education at Mercer University School of Medicine. Retrieved July 2011
http://spinwarp.ucsd.edu/neuroweb/Text/br-300b.htm
"Pancreatic Endocrine Tumors: Radiologic-Clinicopathologic Correlation". RadioGraphics. 30: 1445–1464. doi:10.1148/rg.306105523.
Robbin's Pathology, Eight Ed
3. Expansion of the concept of micropapillary adenocarcinoma to include a newly recognized filigree pattern as well as the classical pattern based on 1468 Stage I lung adenocarcinomas. Emoto K, Eguchi T et al. J Thorac Oncol. 2019 Jul 25. link
Hallman KB, Nahhas WA, Connelly PJ (September 1991). "Endosalpingiosis as a source of psammoma bodies in a Papanicolaou smear. A case report". J Reprod Med. 36 (9): 675–8. PMID 1774734.
Rapini, Ronald. Practical Dermatopathology. Elsevier Mosby, 2005, p. 10.

External links

Slides:

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[1] Johannessen JV, Sobrinho-Simões M (September 1980). "The origin and significance of thyroid psammoma bodies". Lab. Invest. 43 (3): 287–96. PMID 7401638.

[2] Ovarian papillary serous cystadenocarcinoma at WebPath, The Internet Pathology Laboratory for Medical Education at Mercer University School of Medicine. Retrieved July 2011

[3] ttp://spinwarp.ucsd.edu/neuroweb/Text/br-300b.htm

[4] "Pancreatic Endocrine Tumors: Radiologic-Clinicopathologic Correlation". RadioGraphics. 30: 1445–1464. doi:10.1148/rg.306105523.

[5] Robbin's Pathology, Eight Ed

[6] 3. Expansion of the concept of micropapillary adenocarcinoma to include a newly recognized filigree pattern as well as the classical pattern based on 1468 Stage I lung adenocarcinomas. Emoto K, Eguchi T et al. J Thorac Oncol. 2019 Jul 25. link

[pmid1774734-7] Hallman KB, Nahhas WA, Connelly PJ (September 1991). "Endosalpingiosis as a source of psammoma bodies in a Papanicolaou smear. A case report". J Reprod Med. 36 (9): 675–8. PMID 1774734.

[8] Rapini, Ronald. Practical Dermatopathology. Elsevier Mosby, 2005, p. 10.