Peripolesis

Peripolesis is the process in which a cell attaches itself to another cell. This is differentiated from emperipolesis, which is when one cell is engulfed by another.

Peripolesis is thought to be a physiological mechanism involved in regulating some processes of immune response. It was observed between lymphocytes and macrophages following skin grafts between subjects, and after immune challenge with antigens.[1] Peripolesis was also observed in lung alveoli, where the peripolesed macrophages were not injured, but the cell membrane did appear to be temporarily altered.[2] In patients with active sarcoidosis, which is characterized by lymphocyte-macrophage cooperation, lymphocyte peripolesis appeared to occur in clusters and could last for minutes to hours. The lymphocytes could be seen moving around a macrophage while maintaining contact.[3]

References
  1. Sharp, J. A.; Burwell, R. G. (1960-11-05). "Interaction ('Peripolesis') of Macrophages and Lymphocytes after Skin Homografting or Challenge with Soluble Antigens". Nature. 188 (4749): 474–475. doi:10.1038/188474a0.
  2. Lyons DJ, Gautam A, Clark J, Harries MG, Mitchell EB, Milledge JS, Balfour BM (Jan 1992). "Lymphocyte macrophage interactions: peripolesis of human alveolar macrophages". European Respiratory Journal. 5 (1): 59–66. PMID 1577151.
  3. van Maarsseveen, Ton C.; de Groot, Jan; Stam, Jaap; van Diest, Paul J. (1993-05-01). "Peripolesis in Alveolar Sarcoidosis". American Review of Respiratory Disease. 147 (5): 1259–1263. doi:10.1164/ajrccm/147.5.1259. ISSN 0003-0805. PMID 8484640.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.