Pasireotide

Pasireotide (SOM230, trade name Signifor[2]) is an orphan drug approved in the United States[3] and Europe[4] for the treatment of Cushing's disease in patients who fail or are ineligible for surgical therapy.[5][6] It was developed by Novartis. Pasireotide is a somatostatin analog with a 40-fold increased affinity to somatostatin receptor 5 compared to other somatostatin analogs.

Pasireotide
Clinical data
Trade namesSignifor
Other namesSOM230
License data
Routes of
administration		Subcutaneous
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ECHA InfoCard100.211.883
Chemical and physical data
FormulaC58H66N10O9
Molar mass1047.21 g/mol[1] g·mol−1
3D model (JSmol)
 NY (what is this?)  (verify)

Pasireotide was approved for Cushing's disease by the EMA in October 2009[7] and by the FDA in December 2012.[8]

Pasireotide LAR was approved by the FDA for treatment of acromegaly in December 2014, and had been approved for this indication by the EMA one month earlier.[9]

References
  1. Pasireotide | C58H66N10O9 - PubChem https://pubchem.ncbi.nlm.nih.gov/compound/Pasireotide
  2. Signifor® (pasireotide) Official Website for healthcare professionals outside the US http://www.signifor.com/
  3. http://www.accessdata.fda.gov/drugsatfda_docs/label/2012/200677lbl.pdf
  4. http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/002052/WC500128056.pdf
  5. "Novartis drug Signifor® approved in the EU as the first medication to treat patients with Cushing's disease". Retrieved 2012-07-08.
  6. Mancini, Tatiana; Porcelli, Teresa; Giustina, Andrea (2010). "Treatment of Cushing disease: overview and recent findings". Therapeutics and Clinical Risk Management. 6: 505–16. doi:10.2147/TCRM.S12952. PMC 2963160. PMID 21063461.
  7. EMEA Approval for Pasireotide
  8. "FDA Approves Pasireotide for Cushing's Disease".
  9. Tucker, Miriam E. FDA Approves Pasireotide for Treating Acromegaly, Medscape, December 17, 2014, Retrieved 2015-08-21



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