Fenleuton

Fenleuton
Identifiers
	IUPAC name 1-{4-[3-(4-Fluorophenoxy)phenyl]-3-butyn-2-yl}-1-hydroxyurea;
ChemSpider	65045;
Chemical and physical data
Formula	C17H14FN2O3
Molar mass	314.107 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(C#Cc1cccc(c1)Oc2ccc(cc2)F)N(C(=O)N)O;
	InChI InChI=InChI=1S/C17H15FN2O3/c1-12(20(22)17(19)21)5-6-13-3-2-4-16(11-13)23-15-9-7-14(18)8-10-15/h2-4,7-12,22H,1H3,(H2,19,21); Key:MWXPQCKCKPYBDR-UHFFFAOYSA-N[1];

Fenleuton acts as 5-lipoxygenase inhibitor that inhibits leukotriene (LTB4, LTC4, LTD4, and LTE4) formation. It has been studied for potential use in veterinary medicine to treat respiratory diseases such as chronic obstructive pulmonary disease (COPD) in horses.[2]

References

"1-{4-[3-(4-Fluorophenoxy)phenyl]-3-butyn-2-yl}-1-hydroxyurea". chemspider.com. Retrieved 24 December 2015.
Marr KA, Lees P, Page CP, Cunningham FM (1998). "Effect of the 5-lipoxygenase inhibitor, fenleuton, on antigen-induced neutrophil accumulation and lung function changes in horses with chronic obstructive pulmonary disease". J Vet Pharmacol Ther. 21 (3): 241–246. doi:10.1046/j.1365-2885.1998.00127.x. PMID 9673966.

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