Damnacanthal
Damnacanthal is an anthraquinone isolated from the root of Morinda citrifolia, using water [1] or organic solvents.[2]
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| Names | |
|---|---|
| IUPAC name
3-Hydroxy-1-methoxy-9,10-dioxoanthracene-2-carbaldehyde | |
| Other names
3-Hydroxy-1-methoxyanthraquinone-2-aldehyde | |
| Identifiers | |
CAS Number |
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3D model (JSmol) |
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| ChEMBL | |
| ChemSpider | |
| ECHA InfoCard | 100.208.625 |
PubChem CID |
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CompTox Dashboard (EPA) |
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InChI
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SMILES
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| Properties | |
Chemical formula |
C16H10O5 |
| Molar mass | 282.251 g·mol−1 |
| Density | 1.461 g/mL |
| Boiling point | 532 °C (990 °F; 805 K) |
| Related compounds | |
Related arylformaldehydes |
Gossypol Pyridoxal |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
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| Infobox references | |
Pharmacology
In a 1995 in vitro study, damnacanthal was found to act as a potent and selective inhibitor of p56lck tyrosine kinase.[3]
References
- Anekpankul T, Goto M, Sasaki M, et al. (July 2007). "Extraction of anti-cancer damnacanthal from roots of Morinda citrifolia by subcritical water". Separation and Purification Technology. 55 (3): 343–349. doi:10.1016/j.seppur.2007.01.004.
- PMID 21212526
- Faltynek CR, Schroeder J, Mauvais P, et al. (September 1995). "Damnacanthal is a highly potent, selective inhibitor of p56lck tyrosine kinase activity". Biochemistry. 34 (38): 12404–10. doi:10.1021/bi00038a038. PMID 7547985.
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