Befetupitant

Befetupitant (Ro67-5930) is a drug developed by Hoffmann-La Roche which acts as a potent and selective antagonist for the NK1 receptor.[1] It was originally developed as a potential antiemetic drug, though development was ultimately discontinued after a related drug netupitant was deemed to be more suitable for clinical development. Befetupitant has however continued to be researched for other possible applications such as treatment of corneal neovascularization.[2]

Befetupitant
Clinical data
ATC code
  • none
Identifiers
CAS Number
PubChem CID
ChemSpider
Chemical and physical data
FormulaC29H29F6N3O2
Molar mass565.550 g/mol g·mol−1
3D model (JSmol)

References
  1. Hoffmann T, Bös M, Stadler H, Schnider P, Hunkeler W, Godel T, et al. (March 2006). "Design and synthesis of a novel, achiral class of highly potent and selective, orally active neurokinin-1 receptor antagonists". Bioorganic & Medicinal Chemistry Letters. 16 (5): 1362–5. doi:10.1016/j.bmcl.2005.11.047. PMID 16332435.
  2. Bignami F, Giacomini C, Lorusso A, Aramini A, Rama P, Ferrari G (September 2014). "NK1 receptor antagonists as a new treatment for corneal neovascularization". Investigative Ophthalmology & Visual Science. 55 (10): 6783–94. doi:10.1167/iovs.14-14553. PMID 25228541.
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