Apolipoprotein C4

APOC4
Identifiers
Aliases	APOC4, APO-CIV, APOC-IV, apolipoprotein C4
External IDs	OMIM: 600745 MGI: 87878 HomoloGene: 1245 GeneCards: APOC4
Gene location (Human)
Chr.	Chromosome 19 (human)[1]
End	44,945,496 bp[1]
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)[2]
End	19,681,479 bp[2]
Gene ontology
Molecular function	• lipid transporter activity;
Cellular component	• high-density lipoprotein particle; • extracellular region; • very-low-density lipoprotein particle;
Biological process	• lipid transport; • positive regulation of sequestering of triglyceride; • triglyceride homeostasis; • lipid metabolism; • very-low-density lipoprotein particle assembly; • very-low-density lipoprotein particle clearance;
	Sources:Amigo / QuickGO
Orthologs
	346
	11425
	ENSG00000267467
	ENSMUSG00000074336
	P55056
	Q61268
	NM_001646
	NM_007385
	NP_001637
	NP_031411
	Wikidata
View/Edit Human	View/Edit Mouse

Apolipoprotein C-IV, also known as apolipoprotein C4, is a protein that in humans is encoded by the APOC4 gene.[5][6]

Function

Apolipoprotein (apo)C4 gene is a member of the apolipoprotein C gene family. It is expressed in the liver and has a predicted protein structure characteristic of the other genes in this family. Apo C4 is a 3.3-kb gene consisting of 3 exons and 2 introns; it is located 0.5 kb 5' to the APOC2 gene.[5]

References

GRCh38: Ensembl release 89: ENSG00000267467 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000074336 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: apolipoprotein C-IV".
Allan CM, Walker D, Segrest JP, Taylor JM (July 1995). "Identification and characterization of a new human gene (APOC4) in the apolipoprotein E, C-I, and C-II gene locus". Genomics. 28 (2): 291–300. doi:10.1006/geno.1995.1144. PMID 8530039.

External links

Human APOC4 genome location and APOC4 gene details page in the UCSC Genome Browser.

Kim E, Li K, Lieu C, et al. (2008). "Expression of apolipoprotein C-IV is regulated by Ku antigen/peroxisome proliferator-activated receptor gamma complex and correlates with liver steatosis". J. Hepatol. 49 (5): 787–98. doi:10.1016/j.jhep.2008.06.029. PMC 2644636. PMID 18809223.
Burkhardt R, Kenny EE, Lowe JK, et al. (2008). "Common SNPs in HMGCR in micronesians and whites associated with LDL-cholesterol levels affect alternative splicing of exon13". Arterioscler. Thromb. Vasc. Biol. 28 (11): 2078–84. doi:10.1161/ATVBAHA.108.172288. PMC 2764366. PMID 18802019.
Willer CJ, Sanna S, Jackson AU, et al. (2008). "Newly identified loci that influence lipid concentrations and risk of coronary artery disease". Nat. Genet. 40 (2): 161–9. doi:10.1038/ng.76. PMC 5206900. PMID 18193043.
Mak PA, Laffitte BA, Desrumaux C, et al. (2002). "Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta". J. Biol. Chem. 277 (35): 31900–8. doi:10.1074/jbc.M202993200. PMID 12032151.
Liu T, Qian WJ, Gritsenko MA, et al. (2005). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
Kathiresan S, Willer CJ, Peloso GM, et al. (2009). "Common variants at 30 loci contribute to polygenic dyslipidemia". Nat. Genet. 41 (1): 56–65. doi:10.1038/ng.291. PMC 2881676. PMID 19060906.
Mosbruger TL, Duggal P, Goedert JJ, et al. (2010). "Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus". J. Infect. Dis. 201 (9): 1371–80. doi:10.1086/651606. PMC 2853721. PMID 20331378.
Ken-Dror G, Talmud PJ, Humphries SE, Drenos F (2010). "APOE/C1/C4/C2 gene cluster genotypes, haplotypes and lipid levels in prospective Coronary Heart Disease Risk among UK healthy men". Molecular medicine (Cambridge, Mass.). 16 (9–10): 389–99. doi:10.2119/molmed.2010.00044. PMC 2935949. PMID 20498921.
Marques-Vidal P, Bochud M, Paccaud F, et al. (2010). "No interaction between alcohol consumption and HDL-related genes on HDL cholesterol levels". Atherosclerosis. 211 (2): 551–7. doi:10.1016/j.atherosclerosis.2010.04.001. PMID 20430392.
Talmud PJ, Drenos F, Shah S, et al. (2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832. PMID 19913121.
Drenos F, Talmud PJ, Casas JP, et al. (2009). "Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk". Hum. Mol. Genet. 18 (12): 2305–16. doi:10.1093/hmg/ddp159. PMC 2685759. PMID 19336475.
Kathiresan S, Melander O, Guiducci C, et al. (2008). "Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans". Nat. Genet. 40 (2): 189–97. doi:10.1038/ng.75. PMC 2682493. PMID 18193044.
Mancone C, Amicone L, Fimia GM, et al. (2007). "Proteomic analysis of human very low-density lipoprotein by two-dimensional gel electrophoresis and MALDI-TOF/TOF". Proteomics. 7 (1): 143–54. doi:10.1002/pmic.200600339. PMID 17154273.
Lowe JK, Maller JB, Pe'er I, et al. (2009). Gibson G (ed.). "Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae". PLoS Genet. 5 (2): e1000365. doi:10.1371/journal.pgen.1000365. PMC 2628735. PMID 19197348.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Kamboh MI, Aston CE, Hamman RF (2000). "DNA sequence variation in human apolipoprotein C4 gene and its effect on plasma lipid profile". Atherosclerosis. 152 (1): 193–201. doi:10.1016/S0021-9150(99)00459-1. PMID 10996355.
Klos KL, Sing CF, Boerwinkle E, et al. (2006). "Consistent effects of genes involved in reverse cholesterol transport on plasma lipid and apolipoprotein levels in CARDIA participants". Arterioscler. Thromb. Vasc. Biol. 26 (8): 1828–36. doi:10.1161/01.ATV.0000231523.19199.45. PMID 16763159.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Kotite L, Zhang LH, Yu Z, et al. (2003). "Human apoC-IV: isolation, characterization, and immunochemical quantification in plasma and plasma lipoproteins". J. Lipid Res. 44 (7): 1387–94. doi:10.1194/jlr.M300087-JLR200. PMID 12700345.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000267467 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000074336 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: apolipoprotein C-IV".

[pmid8530039-6] Allan CM, Walker D, Segrest JP, Taylor JM (July 1995). "Identification and characterization of a new human gene (APOC4) in the apolipoprotein E, C-I, and C-II gene locus". Genomics. 28 (2): 291–300. doi:10.1006/geno.1995.1144. PMID 8530039.

Lipids: lipoprotein particle metabolism
Lipoprotein particle classes and subclasses	delivery of TGs: Chylomicron VLDL delivery of C and CE: IDL LDL lb LDL sd LDL Lp(a) HDL Remnant cholesterol
Apolipoproteins	APOA 1 2 4 5 APOB APOC 1 2 3 4 APOD APOE APOH SAA SAA1
Extracellular enzymes	LCAT LIPC LPL
Lipid transfer proteins	CETP MTTP PLTP
Cell surface receptors	HDL: SCARB1 IDL: LRP LRP1 LRP1B LRP2 LRP3 LRP4 LRP5 LRP5L LRP6 LRP8 LRP10 LRP11 LRP12 LDL: LDLR LRPAP1
ATP-binding cassette transporter	ABCA1 ABCG5 ABCG8

Apolipoprotein C4

Function

References

External links

Further reading