Thiamine deficiency

From WikEM
(Redirected from Vitamin B1 deficiency)
Jump to: navigation, search

Background

  • Most common cause: chronic alcohol abuse
  • Other causes: malabsorption, hemodialysis, chronic protein-calorie undernutrition
  • IV dextrose can precipitate in patients with marginal thiamine stores

Clinical Features

  • Early/mild features:
    • Anorexia
    • Muscle cramps
    • Paresthesias
    • Irritability
  • Advanced/severe deficiency

Differential Diagnosis

Ethanol related disease processes

Vitamin deficiencies

Evaluation

  • Clinical diagnosis

Management

  • Thiamine 50–100 mg IV for first few days, followed by 5-10mg PO daily
  • Replete other vitamins/electrolytes that may also be depleted (e.g. banana bag, magnesium, folate, multivitamin)
  • Replete thiamine before giving IV dextrose!

See Also

Thiamine deficiency